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学科主题: 临床医学
题名:
Pericryptal fibroblast sheath in intestinal metaplasia, dysplasia and carcinoma of the stomach
作者: Liu, Lu-ying1,4; Sun, Yu1,2; Li, Zhong-wu1,2; Feng, Guoshuang1,3; You, Wei-cheng1,3; Li, Ji-you1,2
关键词: Pericryptal fibroblasts sheath (PCFS) ; Gastric cancer (GC) ; Carcinogenesis ; Intestinal metaplasia (IM) ; Dysplasia
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2009-12-01
DOI: 10.1007/s11670-009-0290-6
卷: 21, 期:4, 页:290-294
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: COLORECTAL EPITHELIAL TUMORS ; MESENCHYMAL CELL SYSTEM ; GASTRIC-CARCINOMA ; REPLICATION MIGRATION ; ECTOPIC EXPRESSION ; NORMAL RABBIT ; ADULT TISSUE ; CDX2 ; COLON ; CYTODIFFERENTIATION
英文摘要:

To investigate the existence of pericryptal fibroblasts sheath (PCFS) in normal gastric mucosa, intestinal metaplasia (IM), indefinite for dysplasia (I-Dys), low grade dysplasia (L-Dys), high grade dysplasia (H-Dys) and gastric cancer (GC), and its association with gastric carcinogenesis.

In this study, we examined the existence of PCFS in normal gastric mucosa (N=10), IM (N=26), I-Dys (N=16), L-Dys (N=13), H-Dys (N=21) and GC (N=145) using immunohistochemical staining for two smooth muscle markers, alpha smooth muscle actin(alpha-SMA) and high molecular weight caldesmon (h-CD). The significance of PCFS was discussed, especially in association with gastric carcinogenesis.

The PCFS was recognized in 65.4%(17/26) of IM, 62.5%(10/16) of I-Dys and 23.1% (3/13) of L-Dys respectively. No PCFS was detected in H-Dys and GC. The PCFS was gradually reduced in IM, Dys and GC in sequence (P < 0.0001).

The PCFS is associated with the differentiation of epithelium and involved in gastric carcinogenesis via epithelial-mesenchymal interaction.

语种: 英语
所属项目编号: 2005B-44 ; 2006AA02A402 ; 2004CB518702
项目资助者: Beijing Municipal Science &amp ; Technology commission NOVA program ; National "863" High-Tech Res &amp ; Dev program of China ; Major State Basic Research Program of china
WOS记录号: WOS:000272158500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51750
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Binzhou Med Coll, Dept Pathol, Binzhou, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Pathol, Beijing 100142, Peoples R China
4.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Canc Epidemiol, Beijing 100142, Peoples R China

Recommended Citation:
Liu, Lu-ying,Sun, Yu,Li, Zhong-wu,et al. Pericryptal fibroblast sheath in intestinal metaplasia, dysplasia and carcinoma of the stomach[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(4):290-294.
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