IR@PKUHSC  > 北京大学深圳医院
学科主题临床医学
Expression of the Lymphocyte Chemokine XCL1 in Lung Tissue of COPD Mice, and Its Relationship to CD4(+)/CD8(+) Ratio and IL-2
Zhuo, Songming1; Li, Na1; Zheng, Yi1; Peng, Xiao2; Xu, Anying3; Ge, Yun1
关键词Chronic Obstructive Pulmonary Disease Xcl1 t Lymphocyte Subsets Interleukin-2
刊名CELL BIOCHEMISTRY AND BIOPHYSICS
2015-11-01
DOI10.1007/s12013-015-0690-9
73期:2页:505-511
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]OBSTRUCTIVE PULMONARY-DISEASE ; DENDRITIC CELL MATURATION ; MURINE MODEL ; T-CELLS ; INFLAMMATION ; LYMPHOTACTIN ; EMPHYSEMA ; PATHOLOGY ; EXPOSURE ; SMOKERS
英文摘要

We tested the role of the lymphocyte chemokine XCL1 in a murine model of chronic obstructive pulmonary disease (COPD). COPD was instigated in mice by a 12-week exposure to cigarette smoke. Some COPD animals additionally received intranasal injections of recombinant XCL1. We demonstrated that the expression of CD4(+) T cells diminished, while CD8(+) counts increased in the lungs of COPD mice, and that these changes were further aggravated by exogenous XCL1. The levels of XCL1 negatively correlated with CD4(+)/CD8(+) ratio (r = -0.945, p < 0.05). In addition, the levels of this chemokine negatively correlated with the levels of interleukin-2, the lymphokine that is produced by activated CD4(+). This observation further supported negative association between XCL1 and CD4(+) response in an experimental model of COPD. In conclusion, murine model of COPD is characterized by elevated levels of XCL1, increased counts of CD8(+) T cells and diminished ratio of CD4(+)/CD8(+) cells, and decreased activity of CD4(+) T cells. This indicates that XCL1 is involved in chronic inflammatory processes in COPD and may be an important pharmacological target in this disease.

语种英语
WOS记录号WOS:000362009900037
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51755
Collection北京大学深圳医院
作者单位1.Longgang Dist Cent Hosp Shenzhen, Shenzhen 518116, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 1, Zhuhai 519041, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Shenzhen 518116, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Zhuo, Songming,Li, Na,Zheng, Yi,et al. Expression of the Lymphocyte Chemokine XCL1 in Lung Tissue of COPD Mice, and Its Relationship to CD4(+)/CD8(+) Ratio and IL-2[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2015,73(2):505-511.
APA Zhuo, Songming,Li, Na,Zheng, Yi,Peng, Xiao,Xu, Anying,&Ge, Yun.(2015).Expression of the Lymphocyte Chemokine XCL1 in Lung Tissue of COPD Mice, and Its Relationship to CD4(+)/CD8(+) Ratio and IL-2.CELL BIOCHEMISTRY AND BIOPHYSICS,73(2),505-511.
MLA Zhuo, Songming,et al."Expression of the Lymphocyte Chemokine XCL1 in Lung Tissue of COPD Mice, and Its Relationship to CD4(+)/CD8(+) Ratio and IL-2".CELL BIOCHEMISTRY AND BIOPHYSICS 73.2(2015):505-511.
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