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学科主题: 药学
题名:
Synthetic N-Alkylated Iminosugars as New Potential Immunosuppressive Agents
作者: Wang, Guan-Nan1; Xiong, Yulan1; Ye, Jia1; Zhang, Li-He1; Ye, Xin-Shan1
关键词: Iminosugar ; immunosuppressive agent ; mouse skin allograft ; synthesis
刊名: ACS MEDICINAL CHEMISTRY LETTERS
发表日期: 2011-09-01
DOI: 10.1021/ml2000998
卷: 2, 期:9, 页:682-686
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CYCLOSPORINE-A ; DERIVATIVES ; INHIBITORS ; 1,5-DIDEOXY-1,5-IMINOXYLITOL ; 1-N-IMINOSUGARS ; TRANSPLANTATION ; MECHANISM ; DISEASE ; ANALOGS ; DESIGN
英文摘要:

The new emerging immunosuppressive effects displayed by iminosugars have not been much investigated so far. Several new N-alkyl dideoxy iminoalditols were designed and synthesized to explore their immunosuppressive effects. These iminosugars inhibited the proliferation of mouse splenocytes and the secretion of both IFN-gamma and IL-4, which are the hallmark cytokines of Th1 and Th2 cells, respectively. Some compounds exerted good inhibitory effects. More importantly, the synthetic iminosugars prolonged the allograft survival in the mouse skin transplantation experiment. Our results provide a lead for further elucidation of the structure-activity relationships and modifications of iminosugars for better immunosuppressive agents.

语种: 英语
所属项目编号: 21072014 ; 20732001
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000294790100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51759
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Guan-Nan,Xiong, Yulan,Ye, Jia,et al. Synthetic N-Alkylated Iminosugars as New Potential Immunosuppressive Agents[J]. ACS MEDICINAL CHEMISTRY LETTERS,2011,2(9):682-686.
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