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Synthetic N-Alkylated Iminosugars as New Potential Immunosuppressive Agents
Wang, Guan-Nan1; Xiong, Yulan1; Ye, Jia1; Zhang, Li-He1; Ye, Xin-Shan1
关键词Iminosugar Immunosuppressive Agent Mouse Skin Allograft Synthesis
刊名ACS MEDICINAL CHEMISTRY LETTERS
2011-09-01
DOI10.1021/ml2000998
2期:9页:682-686
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]CYCLOSPORINE-A ; DERIVATIVES ; INHIBITORS ; 1,5-DIDEOXY-1,5-IMINOXYLITOL ; 1-N-IMINOSUGARS ; TRANSPLANTATION ; MECHANISM ; DISEASE ; ANALOGS ; DESIGN
英文摘要

The new emerging immunosuppressive effects displayed by iminosugars have not been much investigated so far. Several new N-alkyl dideoxy iminoalditols were designed and synthesized to explore their immunosuppressive effects. These iminosugars inhibited the proliferation of mouse splenocytes and the secretion of both IFN-gamma and IL-4, which are the hallmark cytokines of Th1 and Th2 cells, respectively. Some compounds exerted good inhibitory effects. More importantly, the synthetic iminosugars prolonged the allograft survival in the mouse skin transplantation experiment. Our results provide a lead for further elucidation of the structure-activity relationships and modifications of iminosugars for better immunosuppressive agents.

语种英语
WOS记录号WOS:000294790100007
项目编号21072014 ; 20732001
资助机构National Natural Science Foundation of China
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51759
专题北京大学药学院
北京大学药学院_药物化学系
北京大学药学院_分子与细胞药理学系
北京大学精神卫生研究所_药房
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Guan-Nan,Xiong, Yulan,Ye, Jia,et al. Synthetic N-Alkylated Iminosugars as New Potential Immunosuppressive Agents[J]. ACS MEDICINAL CHEMISTRY LETTERS,2011,2(9):682-686.
APA Wang, Guan-Nan,Xiong, Yulan,Ye, Jia,Zhang, Li-He,&Ye, Xin-Shan.(2011).Synthetic N-Alkylated Iminosugars as New Potential Immunosuppressive Agents.ACS MEDICINAL CHEMISTRY LETTERS,2(9),682-686.
MLA Wang, Guan-Nan,et al."Synthetic N-Alkylated Iminosugars as New Potential Immunosuppressive Agents".ACS MEDICINAL CHEMISTRY LETTERS 2.9(2011):682-686.
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