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学科主题: 基础医学
题名:
Pseudomonas aeruginosa isolates of distinct sub-genotypes exhibit similar potential of antimicrobial resistance by drugs exposure
作者: Liu, Zhen-Hong1,2; Xu, Yan2; Duo, Li-Bo3; Liu, Yu4; Xu, Zhao-Zhen5; Burns, Jane L.6,7; Liu, Gui-Rong2; Yang, Bao-Feng1; Liu, Shu-Lin2,8,9
关键词: Pseudomonas aeruginosa ; Sub-genotypes ; Antimicrobial resistance
刊名: ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
发表日期: 2013-04-01
DOI: 10.1007/s10482-012-9862-4
卷: 103, 期:4, 页:797-807
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: CYSTIC-FIBROSIS PATIENTS ; RIBOSOMAL-RNA GENE ; SALMONELLA-TYPHI ; CHLAMYDOMONAS-EUGAMETOS ; OPPORTUNISTIC PATHOGEN ; GENOME ; ENDONUCLEASE ; SEQUENCE ; INTRON ; CONSERVATION
英文摘要:

Pseudomonas aeruginosa, a wide-spread opportunistic pathogen, often complicates clinical treatments due to its resistance to a large variety of antimicrobials, especially in immune compromised patients, occasionally leading to death. However, the resistance to antimicrobials varies greatly among the P. aeruginosa isolates, which raises a question on whether some sub-lineages of P. aeruginosa might have greater potential to develop antimicrobial resistance than others. To explore this question, we divided 160 P. aeruginosa isolates collected from cities of USA and China into distinct genotypes using I-CeuI, a special endonuclease that had previously been proven to reveal phylogenetic relationships among bacteria reliably due to the highly conserved 26-bp recognition sequence. We resolved 10 genotypes by I-CeuI analysis and further divided them into 82 sub-genotypes by endonuclease cleavage with SpeI. Eight of the 10 genotypes contained both multi-drug resistant (MDR) and less resistant isolates based on comparisons of their antimicrobial resistance profiles (ARPs). When the less resistant or susceptible isolates from different genotypes were exposed to eight individual antimicrobials, they showed similar potential to become resistant with minor exceptions. This is to our knowledge the first report to examine correlations between phylogenetic sub-lineages of P. aeruginosa and their potential to become resistant to antimicrobials. This study further alerts the importance and urgency of antimicrobial abuse control.

语种: 英语
所属项目编号: HCXB2009020 ; NSFC309 70078
项目资助者: Harbin Medical University ; National Natural Science Foundation of China ; Natural Science Foundation of Heilongjiang Province of China
WOS记录号: WOS:000316145900011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51762
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Seattle Childrens Hosp, Div Infect Dis, Seattle, WA USA
2.Univ Washington, Seattle, WA 98195 USA
3.Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB, Canada
4.Harbin Med Univ, Dept Pharmacol, Harbin 150081, Peoples R China
5.Harbin Med Univ, Genom Res Ctr, Harbin 150081, Peoples R China
6.Harbin Med Univ, Clin Lab, Affiliated Hosp 2, Harbin 150081, Peoples R China
7.Harbin Med Univ, Clin Lab, Affiliated Hosp 4, Harbin 150081, Peoples R China
8.Harbin Med Univ, Clin Lab, Affiliated Hosp 1, Harbin 150081, Peoples R China
9.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Zhen-Hong,Xu, Yan,Duo, Li-Bo,et al. Pseudomonas aeruginosa isolates of distinct sub-genotypes exhibit similar potential of antimicrobial resistance by drugs exposure[J]. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY,2013,103(4):797-807.
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