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学科主题: 临床医学
题名:
Subfoveal choroidal thickness after photodynamic therapy in patients with acute idiopathic central serous chorioretinopathy
作者: Dang, Yalong1,2,3; Sun, Xinfeng2; Xu, Yongsheng3; Mu, Yalin2; Zhao, Manli2; Zhao, Jing2; Zhu, Yu1; Zhang, Chun3
关键词: idiopathic central serous chorioretinopathy ; photodynamic therapy ; subfoveal choroidal thickness ; indocyanine green angiography ; optical coherence tomography ; enhanced depth imaging
刊名: THERAPEUTICS AND CLINICAL RISK MANAGEMENT
发表日期: 2014
DOI: 10.2147/TCRM.S54213
卷: 10, 页:37-43
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Health Care Sciences & Services
研究领域[WOS]: Health Care Sciences & Services
关键词[WOS]: OPTICAL COHERENCE TOMOGRAPHY ; INDOCYANINE GREEN VIDEOANGIOGRAPHY ; TERM-FOLLOW-UP ; PIGMENT-EPITHELIUM ; AXIAL LENGTH ; HUMAN EYES ; ANGIOGRAPHY ; DETACHMENT ; REPRODUCIBILITY ; VERTEPORFIN
英文摘要:

Background: The purpose of this study was to evaluate changes in subfoveal choroidal thickness after photodynamic therapy in patients with acute idiopathic central serous chorioretinopathy (ICSCR).

Methods: This was a retrospective observational study conducted in 63 participants. The primary outcome measure was subfoveal choroidal thickness at baseline and 3 days, one week, 4 weeks, and 12 weeks after photodynamic therapy. The secondary outcome measure was indocyanine green angiography at baseline and 4 weeks and 12 weeks after photodynamic therapy.

Results: Four weeks after photodynamic therapy, 20 (64.51%) symptomatic eyes showed hypofluorescence corresponding to the area of photodynamic therapy irradiation at the posterior pole. The mean subfoveal choroidal thickness increased significantly from 422 +/- 132 mu m at baseline to 478 +/- 163 mu m at day 3 after treatment (P=0.022) and then decreased to 362 +/- 113 mu m at week 4 (P<0.001) and 339 +/- 135 mu m at week 12 (P<0.001).

Conclusion: The subfoveal choroid in patients with acute ICSCR is thicker than in the normal population, and in symptomatic eyes is significantly thicker than in fellow eyes. Photodynamic therapy using a one third dose of verteporfin may decrease choroidal vascular hyperpermeability and choroidal thickness in patients with acute ICSCR.

语种: 英语
WOS记录号: WOS:000329432200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51764
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Zhengzhou Univ, Affiliated Hosp 1, Dept Ophthalmol, Zhengzhou 450052, Henan Province, Peoples R China
2.Henan Univ Sci & Technol, Dept Ophthalmol, Yellow River Hosp, Sanmenxia, Henan Province, Peoples R China
3.Peking Univ, Clin Stem Cell Res Ctr, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Dang, Yalong,Sun, Xinfeng,Xu, Yongsheng,et al. Subfoveal choroidal thickness after photodynamic therapy in patients with acute idiopathic central serous chorioretinopathy[J]. THERAPEUTICS AND CLINICAL RISK MANAGEMENT,2014,10:37-43.
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