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学科主题: 临床医学
题名:
Treatment of late lithium-pilocarpine-induced status epilepticus with diazepam
作者: Gao, Xu-Guang; Liu, Yang; Liu, Xian-Zeng
关键词: status epilepticus ; rat ; continuous ictal discharges ; late periodic epileptiform discharges
刊名: EPILEPSY RESEARCH
发表日期: 2007-05-01
DOI: 10.1016/j.eplepsyres.2007.02.004
卷: 74, 期:2-3, 页:126-130
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CONVULSIVE STATUS EPILEPTICUS ; SUBTHALAMIC NUCLEUS ; SUBSTANTIA-NIGRA ; MODEL ; RATS ; SEIZURES ; EPILEPSY ; BRAIN
英文摘要:

Purpose: It is well known that status epilepticus (SE) becomes increasingly difficult to control over time. Previous studies have indicated that the electroencephalographic pattern at the time of intervention is predictive of the probability of successful treatment. However, these findings are based on studies limited to the first 2 h of SE onset. Little data is available on the efficacy of treating SE at later time points.

Methods: The aim of the present study was to investigate the efficacy of diazepam (DZP) treatment given at two different phases of SE in a lithium-pilocarpine rat mode[: during continuous ictal discharges (CIDs, phase 3), and during late periodic epileptiform discharges (late PEDs, phase 5). Changes in cortical and hippocampal electroencephalographs (EEGs) were observed continuously during the phases of SE, as well as at 24, 36, 48, and 72 h after SE onset. The effects of DZP treatment during CIDs or during late PEDs were compared to control DZP-untreated rats.

Results: In all three groups, hippocampal and cortical EEGs displayed five distinct phases of SE. There were no statistical differences in the duration of phases 1 and 2 among the three groups. Although DZP administration during CIDs did not terminate CIDs in most rats, it did significantly shorten the duration of phases 3 and 4 of SE. Importantly, DZP given during phase 5 successfully ended behavioral and electrographic seizures in most rats.

Conclusions: Hippocampal and cortical EEGs displayed five distinct phases of SE that were similarly responsive to DZP treatment. Termination of electrographic seizures with DZP treatment was more effective in the last phase of SE (late PEDs) than in phase 3 (CIDs). These findings suggest that previous reports of DZPs decrease in efficacy over time may not be applicable to DZP treatment at 4 h-post onset. (C) 2007 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000246836300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51765
Appears in Collections:北京大学第二临床医学院_神经内科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China

Recommended Citation:
Gao, Xu-Guang,Liu, Yang,Liu, Xian-Zeng. Treatment of late lithium-pilocarpine-induced status epilepticus with diazepam[J]. EPILEPSY RESEARCH,2007,74(2-3):126-130.
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