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学科主题临床医学
Urinary Angiotensin Converting Enzyme 2 Increases in Patients With Type 2 Diabetic Mellitus
Liang, Yaoxian; Deng, Hui; Bi, Shuhong; Cui, Zhuan; Lata, A.; Zheng, Danxia; Wang, Yue
关键词Diabetic Nephropathy Angiotensin Converting Enzyme 2 Renin Angiotensin System Hypertension
刊名KIDNEY & BLOOD PRESSURE RESEARCH
2015
DOI10.1159/000368486
40期:2页:101-110
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Physiology ; Urology & Nephrology ; Peripheral Vascular Disease
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Physiology ; Urology & Nephrology ; Cardiovascular System & Cardiology
关键词[WOS]ANGIOTENSIN-CONVERTING-ENZYME-2 ACE2 ; KIDNEY-DISEASE ; EXPRESSION ; CARBOXYPEPTIDASE ; NEPHROPATHY ; MICE ; RECEPTOR ; HOMOLOG ; ADAM17 ; CELLS
英文摘要

Background/Aims: Angiotensin converting enzyme 2 (ACE2) is highly expressed in the kidney and recognized to be renoprotective by degrading Angiotensin II to Angiotensin (17) in diabetic nephropathy. However, little is known about the role of urinary ACE2 (UACE2) in diabetes. The present study was performed to evaluate UACE2 levels in type 2 diabetic patients with various degrees of albuminuria and its associations with metabolic parameters. The effect of RAS inhibitors on UACE2 excretion was also assessed. Methods: A total of 132 type 2 diabetic patients with different degrees of albuminuria and 34 healthy volunteers were studied. UACE2 levels and activity were measured. Results: Compared to healthy controls, UACE2 to creatinine (UACE2/Cr) levels were significantly increased in both albuminuric and non-albuminuric diabetic patients. UACE2/Cr levels were much higher in hypertensive diabetic patients compared with their normotensive counterparts and treatment with RAS inhibitors markedly attenuated the augmentation. Furthermore, UACE2/Cr was positively correlated with fasting blood glucose, hemoglobin A1C (HbA1C), triglyceride, and total cholesterol. In multiple regression analysis, UACE2/Cr was independently predicted by HbA1C and RAS inhibitors treatment. Conclusions: UACE2 increased in type 2 diabetic patients with various degrees of albuminuria and RAS inhibitors suppresses UACE2 excretion. UACE2 might potentially function as a marker for monitoring the metabolic status and therapeutic response of RAS inhibitors in diabetes. Copyright (C) 2015 S. Karger AG, Basel

语种英语
所属项目编号81070213
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000353719300001
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51766
专题北京大学第三临床医学院_肾内科
作者单位Peking Univ, Hosp 3, Dept Nephrol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Liang, Yaoxian,Deng, Hui,Bi, Shuhong,et al. Urinary Angiotensin Converting Enzyme 2 Increases in Patients With Type 2 Diabetic Mellitus[J]. KIDNEY & BLOOD PRESSURE RESEARCH,2015,40(2):101-110.
APA Liang, Yaoxian.,Deng, Hui.,Bi, Shuhong.,Cui, Zhuan.,Lata, A..,...&Wang, Yue.(2015).Urinary Angiotensin Converting Enzyme 2 Increases in Patients With Type 2 Diabetic Mellitus.KIDNEY & BLOOD PRESSURE RESEARCH,40(2),101-110.
MLA Liang, Yaoxian,et al."Urinary Angiotensin Converting Enzyme 2 Increases in Patients With Type 2 Diabetic Mellitus".KIDNEY & BLOOD PRESSURE RESEARCH 40.2(2015):101-110.
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