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Downregulation of ABI1 expression affects the progression and prognosis of human gastric carcinoma
Cui, Meihua1,4; Yu, Weidong2; Dong, Jianqiang2; Chen, Jie3; Zhang, Xiuru5; Liu, Yulan1
关键词Abelson Interactor Protein-1 (Abi1) Gastric Cancer Immunohistochemistry (Ihc) Prognosis
刊名MEDICAL ONCOLOGY
2010-09-01
DOI10.1007/s12032-009-9260-6
27期:3页:632-639
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者Peking University People&prime ; s Hospital Research and Development Foundation ; Peking University People&prime ; s Hospital Research and Development Foundation
研究领域[WOS]Oncology
关键词[WOS]EPIDERMAL-GROWTH-FACTOR ; CANCER STATISTICS ; BINDING-PROTEIN ; IN-VITRO ; ABL ; ACTIVATION ; MIGRATION ; LEUKEMOGENESIS ; DEGRADATION ; KINASES
英文摘要

Abelson interactor protein-1 (ABI1) is a promising candidate tumor suppressor, and plays critical roles both in the pathogenesis of BCR-Abl-induced leukemia and in the spread of several solid tumors. The expression of ABU and its role in cancer progression and prognosis are largely unknown in the majority of solid tumors, including gastric cancer. In this study, we analyzed the correlation between ABI1 expression and the clinicopathological characteristics, tumor progression, and prognosis of patients with gastric carcinoma. Tissue specimens were from 103 gastric cancer patients who underwent gastrectomy in our hospital between January 2000 and December 2007. Among them 59 tumor tissue samples were matched with normal tissue samples. The expression of ABI1 protein was measured using immunohistochemical staining of paraffin-embedded tissue specimens. Meanwhile, quantitative real-time RT-PCR and Western blotting were used to identify the expression of ABI1 in human gastric normal mucosal cell line (GES-1) and gastric cancer cell lines (N87, AGS). We performed a statistical analysis of the potential correlation between ABI1 expression and the patients′ clinicopathological characteristics, 5-year survival, and median survival time. The immunohistochemical staining results of 59 patients showed that ABI1 was expressed in 28.8% (17/59) of gastric cancer tissues, compared to 91.5% (54/59) of normal samples. ABI1 expression in 103 patients was strongly correlated with tumor differentiation, clinical stage, and lymph node status (P < 0.01). The 5-year survival rate was 15.3% in the ABI1-negative group and 63.7% in the ABI1-positive group. Median survival time in the ABI1-negative and ABI1-positive groups was 25.0 months (95% CI: 19.7-30.3) and 74.0 months (95% CI: 54.6-93.3), respectively. There was a significant difference between the two groups (chi(2) = 10.888, P = 0.001). Furthermore, we found that ABI1 expressed lowly in poor differentiated AGS, whereas highly in GES-1 and well-differentiated N87. Downregulation of ABI1 expression in human gastric carcinoma may play a critical role in tumor progression and in determining patient prognosis. ABI1 may be a useful diagnostic or prognostic molecular biomarker, and might be a potential target for therapeutic intervention.

语种英语
所属项目编号RDB2008-06
资助者Peking University People&prime ; s Hospital Research and Development Foundation ; Peking University People&prime ; s Hospital Research and Development Foundation
WOS记录号WOS:000281522400010
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51767
专题北京大学第二临床医学院_消化科
作者单位1.Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Clin Mol Biol, Beijing 100044, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Clin Epidemiol, Beijing 100044, Peoples R China
4.Peking Univ, Aerosp Ctr Hosp, Dept Gastroenterol, Beijing 100049, Peoples R China
5.Peking Univ, Aerosp Ctr Hosp, Dept Pathol, Beijing 100049, Peoples R China
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Cui, Meihua,Yu, Weidong,Dong, Jianqiang,et al. Downregulation of ABI1 expression affects the progression and prognosis of human gastric carcinoma[J]. MEDICAL ONCOLOGY,2010,27(3):632-639.
APA Cui, Meihua,Yu, Weidong,Dong, Jianqiang,Chen, Jie,Zhang, Xiuru,&Liu, Yulan.(2010).Downregulation of ABI1 expression affects the progression and prognosis of human gastric carcinoma.MEDICAL ONCOLOGY,27(3),632-639.
MLA Cui, Meihua,et al."Downregulation of ABI1 expression affects the progression and prognosis of human gastric carcinoma".MEDICAL ONCOLOGY 27.3(2010):632-639.
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