|Impact of Emphysema Heterogeneity on Pulmonary Function|
|Ju, Jieyang1; Li, Ruosha2; Gu, Suicheng1; Leader, Joseph K.1; Wang, Xiaohua3; Chen, Yahong3; Zheng, Bin4; Wu, Shandong1; Gur, David1; Sciurba, Frank5; Pu, Jiantao1,6|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||VOLUME-REDUCTION SURGERY ; COMPUTED-TOMOGRAPHY ; REGIONAL-DISTRIBUTION ; LUNG ; COPD ; CT ; DISEASE ; DEFICIENCY ; PHYSIOLOGY ; SMOKERS|
Objectives: To investigate the association between emphysema heterogeneity in spatial distribution, pulmonary function and disease severity.
Methods and Materials: We ascertained a dataset of anonymized Computed Tomography (CT) examinations acquired on 565 participants in a COPD study. Subjects with chronic bronchitis (CB) and/or bronchodilator response were excluded resulting in 190 cases without COPD and 160 cases with COPD. Low attenuations areas (LAAs) (<= 950 Hounsfield Unit (HU)) were identified and quantified at the level of individual lobes. Emphysema heterogeneity was defined in a manner that ranged in value from -100% to 100%. The association between emphysema heterogeneity and pulmonary function measures (e. g., FEV1% predicted, RV/TLC, and DLco% predicted) adjusted for age, sex, and smoking history (pack-years) was assessed using multiple linear regression analysis.
Results: The majority (128/160) of the subjects with COPD had a heterogeneity greater than zero. After adjusting for age, gender, smoking history, and extent of emphysema, heterogeneity in depicted disease in upper lobe dominant cases was positively associated with pulmonary function measures, such as FEV1 Predicted (p<.001) and FEV1/FVC (p<.001), as well as disease severity (p<0.05). We found a negative association between HI%, RV/TLC (p<0.001), and DLco% (albeit not a statistically significant one, p = 0.06) in this group of patients.
Conclusion: Subjects with more homogeneous distribution of emphysema and/or lower lung dominant emphysema tend to have worse pulmonary function.
|项目编号||RO1 HL096613 ; 201402013|
|资助机构||National Institutes of Health ; Bonnie J. Addario Lung Cancer Foundation ; National Health and Family Planning Commission of the R.R. China|
|作者单位||1.Peking Univ, Affiliated Hosp 3, Beijing 100871, Peoples R China|
2.Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15260 USA
3.Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA
4.Univ Oklahoma, Sch Elect & Comp Engn, Norman, OK 73019 USA
5.Univ Pittsburgh, Dept Med, Pittsburgh, PA USA
6.Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA USA
|Ju, Jieyang,Li, Ruosha,Gu, Suicheng,et al. Impact of Emphysema Heterogeneity on Pulmonary Function[J]. PLOS ONE,2014,9(11).|
|APA||Ju, Jieyang.,Li, Ruosha.,Gu, Suicheng.,Leader, Joseph K..,Wang, Xiaohua.,...&Pu, Jiantao.(2014).Impact of Emphysema Heterogeneity on Pulmonary Function.PLOS ONE,9(11).|
|MLA||Ju, Jieyang,et al."Impact of Emphysema Heterogeneity on Pulmonary Function".PLOS ONE 9.11(2014).|