IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Impact of Emphysema Heterogeneity on Pulmonary Function
Ju, Jieyang1; Li, Ruosha2; Gu, Suicheng1; Leader, Joseph K.1; Wang, Xiaohua3; Chen, Yahong3; Zheng, Bin4; Wu, Shandong1; Gur, David1; Sciurba, Frank5; Pu, Jiantao1,6
刊名PLOS ONE
2014-11-19
DOI10.1371/journal.pone.0113320
9期:11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Institutes of Health ; Bonnie J. Addario Lung Cancer Foundation ; National Health and Family Planning Commission of the R.R. China ; National Institutes of Health ; Bonnie J. Addario Lung Cancer Foundation ; National Health and Family Planning Commission of the R.R. China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]VOLUME-REDUCTION SURGERY ; COMPUTED-TOMOGRAPHY ; REGIONAL-DISTRIBUTION ; LUNG ; COPD ; CT ; DISEASE ; DEFICIENCY ; PHYSIOLOGY ; SMOKERS
英文摘要

Objectives: To investigate the association between emphysema heterogeneity in spatial distribution, pulmonary function and disease severity.

Methods and Materials: We ascertained a dataset of anonymized Computed Tomography (CT) examinations acquired on 565 participants in a COPD study. Subjects with chronic bronchitis (CB) and/or bronchodilator response were excluded resulting in 190 cases without COPD and 160 cases with COPD. Low attenuations areas (LAAs) (<= 950 Hounsfield Unit (HU)) were identified and quantified at the level of individual lobes. Emphysema heterogeneity was defined in a manner that ranged in value from -100% to 100%. The association between emphysema heterogeneity and pulmonary function measures (e. g., FEV1% predicted, RV/TLC, and DLco% predicted) adjusted for age, sex, and smoking history (pack-years) was assessed using multiple linear regression analysis.

Results: The majority (128/160) of the subjects with COPD had a heterogeneity greater than zero. After adjusting for age, gender, smoking history, and extent of emphysema, heterogeneity in depicted disease in upper lobe dominant cases was positively associated with pulmonary function measures, such as FEV1 Predicted (p<.001) and FEV1/FVC (p<.001), as well as disease severity (p<0.05). We found a negative association between HI%, RV/TLC (p<0.001), and DLco% (albeit not a statistically significant one, p = 0.06) in this group of patients.

Conclusion: Subjects with more homogeneous distribution of emphysema and/or lower lung dominant emphysema tend to have worse pulmonary function.

语种英语
所属项目编号RO1 HL096613 ; 201402013
资助者National Institutes of Health ; Bonnie J. Addario Lung Cancer Foundation ; National Health and Family Planning Commission of the R.R. China ; National Institutes of Health ; Bonnie J. Addario Lung Cancer Foundation ; National Health and Family Planning Commission of the R.R. China
WOS记录号WOS:000345533200095
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51772
专题北京大学第三临床医学院
作者单位1.Peking Univ, Affiliated Hosp 3, Beijing 100871, Peoples R China
2.Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15260 USA
3.Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA
4.Univ Oklahoma, Sch Elect & Comp Engn, Norman, OK 73019 USA
5.Univ Pittsburgh, Dept Med, Pittsburgh, PA USA
6.Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA USA
推荐引用方式
GB/T 7714
Ju, Jieyang,Li, Ruosha,Gu, Suicheng,et al. Impact of Emphysema Heterogeneity on Pulmonary Function[J]. PLOS ONE,2014,9(11).
APA Ju, Jieyang.,Li, Ruosha.,Gu, Suicheng.,Leader, Joseph K..,Wang, Xiaohua.,...&Pu, Jiantao.(2014).Impact of Emphysema Heterogeneity on Pulmonary Function.PLOS ONE,9(11).
MLA Ju, Jieyang,et al."Impact of Emphysema Heterogeneity on Pulmonary Function".PLOS ONE 9.11(2014).
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