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学科主题: 临床医学
题名:
Relationship between LAPTM4B gene polymorphism and susceptibility of gastric cancer
作者: Liu, Y.1; Zhang, Q. -Y.1; Qian, N.1; Zhou, R. -L.1
关键词: gastric cancer ; gene polymorphism ; LAPTM4B ; susceptibility
刊名: ANNALS OF ONCOLOGY
发表日期: 2007-02-01
DOI: 10.1093/annonc/mdl394
卷: 18, 期:2, 页:311-316
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: LYSOSOMAL MEMBRANE-PROTEIN ; HEPATOCELLULAR-CARCINOMA ; SACCHAROMYCES-CEREVISIAE ; MULTIDRUG-RESISTANCE ; EXPRESSION ; IDENTIFICATION ; TRANSCRIPT
英文摘要:

Background: A novel gene called LAPTM4B (lysosome-associated protein transmembrane 4 beta) was mapped to 8q22, and contains seven exons. The 2.25-kb messenger RNA of the gene encodes a putative lysosome-associated protein with four transmembrane regions. There are two alleles of the gene, named as LAPTM4B*1 and LAPTM4B*2. Allele *1 differs from allele *2 in that it contains only one copy of a 19-bp sequence in the 5′ untranslated region (UTR), whereas this sequence is duplicated and tandemly arranged in allele *2. Studies showed that the allelic variation of LAPTM4B was associated with the genetic susceptibility of hepatocellular carcinoma but not with that of esophageal squamous cell carcinoma. This study was designed to investigate the possible association between the allelic variation of LAPTM4B and the genetic susceptibility of gastric cancer.

Materials and methods: The genotype of LAPTM4B was analyzed in 350 unrelated healthy adult individuals and 214 patients with gastric cancer by utilizing polymerase chain reaction based on specific primers. The genotypic distribution of LAPTM4B was analyzed by chi(2) test.

Results: The allelic frequencies of the *2 were 33.88% and 24.14% in the gastric cancer group and the healthy control group, respectively, which was significantly different between the two groups (P < 0.001). There was a significant difference in the overall genotypic distribution between the patients and the controls (P = 0.023). The risk of suffering from gastric cancer was increased 1.819 times in the individuals of the *1/2 genotype [95% confidence interval (CI) 1.273-2.601] and 2.387 times in the individuals of the *2/2 genotype of LAPTM4B (95% CI 1.195-4.767) compared with the *1/1 genotype. No association between the genotypic distribution of LAPTM4B and the clinical information on patients of gastric cancer such as age, pathological type, differentiation classification of TNM, and infection of hepatitis B virus was shown.

Conclusion: This study indicated that allele *2 of LAPTM4B might be the risk factor of gastric cancer, which could be associated with genetic susceptibility of gastric cancer.

语种: 英语
WOS记录号: WOS:000244124200017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51780
Appears in Collections:北京大学临床肿瘤学院_临床实验室_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Dept Clin Lab, Beijing Canc Hosp & Inst, Beijing 100036, Peoples R China
2.Shanxi Med Univ, Da Tong Univ, Sch Med, Taiyuan, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Y.,Zhang, Q. -Y.,Qian, N.,et al. Relationship between LAPTM4B gene polymorphism and susceptibility of gastric cancer[J]. ANNALS OF ONCOLOGY,2007,18(2):311-316.
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