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学科主题: 基础医学
题名:
CMTM5-v1, a four-transmembrane protein, presents a secreted form released via a vesicle-mediated secretory pathway
作者: Li, Henan; Guo, Xiaohuan; Shao, Luning; Plate, Markus; Mo, Xiaoning; Wang, Yu; Han, Wenling
关键词: CMTM ; Secretion ; TM4SF ; Vesicles
刊名: BMB REPORTS
发表日期: 2010-03-31
卷: 43, 期:3, 页:182-187
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: CHEMOKINE-LIKE FACTOR-1 ; CELL-LINES ; APOPTOSIS ; EXPRESSION ; METHYLATION ; CLONING ; GROWTH ; EXPORT ; CMTM3
英文摘要:

The CKLF-like MARVEL transmembrane domain-containing family (CMTM) is a novel family of proteins linking classical chemokines and the transmembrane 4 superfamily (TM4SF). Our earlier studies indicated several CMTM members (such as CKLF1 and CMTM2) have a secreted form. This is the first report of the secreted form of CMTM5-v1, the major RNA splicing form of CMTM5, which is produced as small vesicles (<100 nm diameter) and floats at a peak density of 1.19 g/ml on continuous sucrose gradients. CMTM5-v1 has no obvious co-localization with CD63 or Golgi complex. In addition, brefeldin A but not wortmannin can inhibit the secretion of CMTM5-v1. Our results suggest that CMTM5-v1 might be secreted via a different vesicle-mediated secretory pathway, which will be helpful for the studies of vesicle-mediated secretion and MARVEL domain-containing proteins. [BMB reports 2010; 43(3): 182-187]

语种: 英语
所属项目编号: 30571691 ; 2006AA02A305 ; NCET-07-0013
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Program for New Century Excellent Talents in University
WOS记录号: WOS:000276278100006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51789
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: Peking Univ, Ctr Human Dis Genom, Dept Immunol, Sch Basic Med Sci,Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Li, Henan,Guo, Xiaohuan,Shao, Luning,et al. CMTM5-v1, a four-transmembrane protein, presents a secreted form released via a vesicle-mediated secretory pathway[J]. BMB REPORTS,2010,43(3):182-187.
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