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Pilot-scale production of low molecular weight peptides from corn wet milling byproducts and the antihypertensive effects in vivo and in vitro
Lin, Feng1; Chen, Liang2; Liang, Rui1; Zhang, Zhaofeng1; Wang, Junbo1; Cai, Muyi2; Li, Yong1
关键词Pilot-scale Production Corn Protein Isolate Enzymatic Hydrolysis Corn Oligopeptides Antihypertensive Effects
刊名FOOD CHEMISTRY
2011-02-01
DOI10.1016/j.foodchem.2010.06.099
124期:3页:801-807
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]ANGIOTENSIN-CONVERTING ENZYME ; ACE INHIBITORY PEPTIDE ; SPONTANEOUSLY HYPERTENSIVE-RATS ; ALGAE PROTEIN WASTE ; ANTIOXIDANT ACTIVITY ; GLUTEN MEAL ; HYDROLYSATE ; CHINENSIS ; GELATIN
英文摘要

A pilot-scale production was developed to enhance the value of proteins from corn gluten meal (CGM). Corn protein isolate (CPI) with high protein content (90.68%) was obtained through heat treatment of CGM (150 kg) in aqueous alkaline solution. Two-step enzymatic hydrolysis and multistage separation were applied to enrich corn oligopeptides (COP) with low molecular weights, 96.77% of which were less than 1000 Da. The greatest antihypertensive effect of COP treatment in spontaneously hypertensive rats (SHR) was observed at a dose of 0.45 g/kg. One major ACE-inhibitory peptide, Ala-Tyr, was identified and quantified (9.16 +/- 0.08 mg/g) from COP. The ACE inhibitory activity of Ala-Tyr (IC(50) = 0.037 mg/ml) was over 27 times higher than that of COP (IC(50) = 1.020 mg/ml). The results indicate that COP may be a source of natural antihypertensive compounds that could be used for drugs or functional food ingredients. (C) 2010 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000283459700014
项目编号2006BAD27B08 ; 2007AA10Z327
资助机构Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51791
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100191, Peoples R China
2.China Natl Res Inst Food & Fermentat Ind, Beijing 100027, Peoples R China
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Lin, Feng,Chen, Liang,Liang, Rui,et al. Pilot-scale production of low molecular weight peptides from corn wet milling byproducts and the antihypertensive effects in vivo and in vitro[J]. FOOD CHEMISTRY,2011,124(3):801-807.
APA Lin, Feng.,Chen, Liang.,Liang, Rui.,Zhang, Zhaofeng.,Wang, Junbo.,...&Li, Yong.(2011).Pilot-scale production of low molecular weight peptides from corn wet milling byproducts and the antihypertensive effects in vivo and in vitro.FOOD CHEMISTRY,124(3),801-807.
MLA Lin, Feng,et al."Pilot-scale production of low molecular weight peptides from corn wet milling byproducts and the antihypertensive effects in vivo and in vitro".FOOD CHEMISTRY 124.3(2011):801-807.
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