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学科主题: 公共卫生
题名:
Pilot-scale production of low molecular weight peptides from corn wet milling byproducts and the antihypertensive effects in vivo and in vitro
作者: Lin, Feng1; Chen, Liang2; Liang, Rui1; Zhang, Zhaofeng1; Wang, Junbo1; Cai, Muyi2; Li, Yong1
关键词: Pilot-scale production ; Corn protein isolate ; Enzymatic hydrolysis ; Corn oligopeptides ; Antihypertensive effects
刊名: FOOD CHEMISTRY
发表日期: 2011-02-01
DOI: 10.1016/j.foodchem.2010.06.099
卷: 124, 期:3, 页:801-807
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]: Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]: ANGIOTENSIN-CONVERTING ENZYME ; ACE INHIBITORY PEPTIDE ; SPONTANEOUSLY HYPERTENSIVE-RATS ; ALGAE PROTEIN WASTE ; ANTIOXIDANT ACTIVITY ; GLUTEN MEAL ; HYDROLYSATE ; CHINENSIS ; GELATIN
英文摘要:

A pilot-scale production was developed to enhance the value of proteins from corn gluten meal (CGM). Corn protein isolate (CPI) with high protein content (90.68%) was obtained through heat treatment of CGM (150 kg) in aqueous alkaline solution. Two-step enzymatic hydrolysis and multistage separation were applied to enrich corn oligopeptides (COP) with low molecular weights, 96.77% of which were less than 1000 Da. The greatest antihypertensive effect of COP treatment in spontaneously hypertensive rats (SHR) was observed at a dose of 0.45 g/kg. One major ACE-inhibitory peptide, Ala-Tyr, was identified and quantified (9.16 +/- 0.08 mg/g) from COP. The ACE inhibitory activity of Ala-Tyr (IC(50) = 0.037 mg/ml) was over 27 times higher than that of COP (IC(50) = 1.020 mg/ml). The results indicate that COP may be a source of natural antihypertensive compounds that could be used for drugs or functional food ingredients. (C) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2006BAD27B08 ; 2007AA10Z327
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000283459700014
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51791
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100191, Peoples R China
2.China Natl Res Inst Food & Fermentat Ind, Beijing 100027, Peoples R China

Recommended Citation:
Lin, Feng,Chen, Liang,Liang, Rui,et al. Pilot-scale production of low molecular weight peptides from corn wet milling byproducts and the antihypertensive effects in vivo and in vitro[J]. FOOD CHEMISTRY,2011,124(3):801-807.
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