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Biotransformation of prim-O-glucosylcimifugin by human intestinal flora and its inhibition on NO production and DPPH free radical
Zhao, Bo1; Yang, Xin-Bao2,3; Yang, Xiu-Wei1; Liu, Jian-Xun2,3
关键词Saposhnikovia Divaricata Chromones Prim-o-glucosylcimifugin Nitric Oxide Dpph Free Radical
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
2012
DOI10.1080/10286020.2012.702756
14期:9页:886-896
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CONSTITUENTS ; GLYCOSIDES ; BACTERIA
英文摘要

prim-O-Glucosylcimifugin (PGCN), a highest content chromone in the roots of Saposhnikovia divaricata, was incubated with human intestinal flora (HIF), and two biotransformation products were obtained from the incubated solution by chromatographic methods. The chemical structures of the two biotransformation products were elucidated as cimifugin (CN) and 5-O-methylvisamminol (MVL), respectively, on the basis of NMR and MS data. The biotransformation product CN was formed through a deglucosylation of PGCN by beta-glucosidase secreted from the HIF, and then the hydroxymethyl group of CN was reduced to lead to occurrence of MVL. All of these compounds were evaluated for their effect on the inhibition of nitric oxide production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and for 1,1-diphenyl-2-picrylhydrazyl free-radical scavenging activity in cell-free bioassay system.

语种英语
WOS记录号WOS:000308984000011
项目编号2011BAI07B08 ; 2009ZX09301-010 ; Z0004105040311
资助机构National Sciences and Technology Program of China ; &prime ; Major New Medicine Project&prime ; in Megaprojects of Science Research of China ; Beijing Municipal Special-Purpose Science Foundation of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51794
专题北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Beijing 100029, Peoples R China
3.China Acad Chinese Med Sci, Xiyuan Hosp, Res Ctr, Beijing 100091, Peoples R China
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GB/T 7714
Zhao, Bo,Yang, Xin-Bao,Yang, Xiu-Wei,et al. Biotransformation of prim-O-glucosylcimifugin by human intestinal flora and its inhibition on NO production and DPPH free radical[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2012,14(9):886-896.
APA Zhao, Bo,Yang, Xin-Bao,Yang, Xiu-Wei,&Liu, Jian-Xun.(2012).Biotransformation of prim-O-glucosylcimifugin by human intestinal flora and its inhibition on NO production and DPPH free radical.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,14(9),886-896.
MLA Zhao, Bo,et al."Biotransformation of prim-O-glucosylcimifugin by human intestinal flora and its inhibition on NO production and DPPH free radical".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 14.9(2012):886-896.
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