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学科主题: 药学
题名:
Biotransformation of prim-O-glucosylcimifugin by human intestinal flora and its inhibition on NO production and DPPH free radical
作者: Zhao, Bo1; Yang, Xin-Bao2,3; Yang, Xiu-Wei1; Liu, Jian-Xun2,3
关键词: Saposhnikovia divaricata ; chromones ; prim-O-glucosylcimifugin ; nitric oxide ; DPPH free radical
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2012
DOI: 10.1080/10286020.2012.702756
卷: 14, 期:9, 页:886-896
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CONSTITUENTS ; GLYCOSIDES ; BACTERIA
英文摘要:

prim-O-Glucosylcimifugin (PGCN), a highest content chromone in the roots of Saposhnikovia divaricata, was incubated with human intestinal flora (HIF), and two biotransformation products were obtained from the incubated solution by chromatographic methods. The chemical structures of the two biotransformation products were elucidated as cimifugin (CN) and 5-O-methylvisamminol (MVL), respectively, on the basis of NMR and MS data. The biotransformation product CN was formed through a deglucosylation of PGCN by beta-glucosidase secreted from the HIF, and then the hydroxymethyl group of CN was reduced to lead to occurrence of MVL. All of these compounds were evaluated for their effect on the inhibition of nitric oxide production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and for 1,1-diphenyl-2-picrylhydrazyl free-radical scavenging activity in cell-free bioassay system.

语种: 英语
所属项目编号: 2011BAI07B08 ; 2009ZX09301-010 ; Z0004105040311
项目资助者: National Sciences and Technology Program of China ; &prime ; Major New Medicine Project&prime ; in Megaprojects of Science Research of China ; Beijing Municipal Special-Purpose Science Foundation of China
WOS记录号: WOS:000308984000011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51794
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Beijing 100029, Peoples R China
3.China Acad Chinese Med Sci, Xiyuan Hosp, Res Ctr, Beijing 100091, Peoples R China

Recommended Citation:
Zhao, Bo,Yang, Xin-Bao,Yang, Xiu-Wei,et al. Biotransformation of prim-O-glucosylcimifugin by human intestinal flora and its inhibition on NO production and DPPH free radical[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2012,14(9):886-896.
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