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Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene
Jia, G1; Wang, HF1; Yan, L1; Wang, X1; Pei, RJ1; Yan, T1; Zhao, YL1; Guo, XB1
刊名ENVIRONMENTAL SCIENCE & TECHNOLOGY
2005-03-01
DOI10.1021/es048729l
39期:5页:1378-1383
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Environmental ; Environmental Sciences
研究领域[WOS]Engineering ; Environmental Sciences & Ecology
关键词[WOS]PULMONARY TOXICITY ; EXPOSURE
英文摘要

A cytotoxicity test protocol for single-wall nanotubes (SWNTs), multi-wall nanotubes (with diameters ranging from 10 to 20 nm, MWNT10), and fullerene (C-60) was tested. Profound cytotoxicity of SWNTs was observed in alveolar macrophage (AM) after a 6-h exposure in vitro. The cytotoxicity increases by as high as similar to35% when the dosage of SWNTs was increased by 11.30 mug/cm(2). No significant toxicity was observed for C60 up to a dose of 226.00 mug/CM2. The cytotoxicity apparently follows a sequence order on a mass basis: SWNTs > MWNT10 > quartz > C-60. SWNTs significantly impaired phagocytosis of AM at the low dose of 0.38 mug/cm(2), whereas MWNT10 and C60 induced injury only at the high dose of 3.06 mug/cm(2). The macrophages exposed to SWNTs or MWNT10 of 3.06 mug/cm(2) showed characteristic features of necrosis and degeneration. A sign of apoptotic cell death likely existed. Carbon nanomaterials with different geometric structures exhibit quite different cytotoxicity and bioactivity in vitro, although they may not be accurately reflected in the comparative toxicity in vivo.

语种英语
WOS记录号WOS:000227257400034
Citation statistics
Cited Times:843[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51799
Collection北京大学公共卫生学院
作者单位1.Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100083, Peoples R China
3.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Jia, G,Wang, HF,Yan, L,et al. Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2005,39(5):1378-1383.
APA Jia, G.,Wang, HF.,Yan, L.,Wang, X.,Pei, RJ.,...&Guo, XB.(2005).Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene.ENVIRONMENTAL SCIENCE & TECHNOLOGY,39(5),1378-1383.
MLA Jia, G,et al."Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene".ENVIRONMENTAL SCIENCE & TECHNOLOGY 39.5(2005):1378-1383.
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