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学科主题: 基础医学
题名:
Peripheral electric stimulation attenuates the expression of cocaine-induced place preference in rats
作者: Ren, YH; Wang, B; Luo, F; Cui, CL; Zheng, JW; Han, JS
关键词: reward ; craving ; conditioned place preference ; peripheral electric stimulation ; cocaine ; opioid
刊名: BRAIN RESEARCH
发表日期: 2002-12-06
卷: 957, 期:1, 页:129-135
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: OPIOID RECEPTOR AGONIST ; INDUCED DELAYED AMNESIA ; DIFFERENT FREQUENCIES ; DYNORPHIN A-(1-13) ; KAPPA ; ELECTROACUPUNCTURE ; MICE ; REINSTATEMENT ; SUPPRESSION ; ANTAGONIST
英文摘要:

The present study was designed to investigate the effect of peripheral electrical stimulation (PES), with high (100 Hz) or low (2 Hz) frequencies, on the expression of cocaine-induced conditioned place preference (CPP). Rats were trained with cocaine (0.1-10 mg/kg, i.p.) under a biased paradigm in a three-compartment chamber for the development of a CPP. One day following the last conditioning, the total time spent in each compartment was recorded after the deliverance of PES. Naloxone (1, 5, and 10 mg/kg, i.p.) was applied to investigate whether endogenous opioid receptor pathways play any role in the effect of PES. It was found that (1) 1 mg/kg and higher doses of cocaine, but not 0.5 mg/kg, produced significant place preference, (2) cocaine-induced CPP, once developed, maintained for more than 13 days in a cocaine-free state, (3) PES of 100 Hz, but not 2 Hz, significantly attenuated the expression of cocaine-induced CPP (P<0.01), (4) PES per se did not influence the natural place preference in rats, and (5) the inhibition of cocaine CPP induced by 100 Hz PES could be reversed by naloxone pre-treatment at 10 mg/kg, but not at lower doses. These results suggest that PES could inhibits cocaine-induced CPP in a frequency-dependent manner. This effect is probably mediated by an endogenous κ-opioid mechanism. (C) 2002 Elsevier Science B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000179621200015
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51804
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Beijing Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Ren, YH,Wang, B,Luo, F,et al. Peripheral electric stimulation attenuates the expression of cocaine-induced place preference in rats[J]. BRAIN RESEARCH,2002,957(1):129-135.
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