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学科主题: 临床医学
题名:
Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma
作者: Piao, G-H.1; Piao, W-H.2,3; He, Y.3; Zhang, H-H.3; Wang, G-Q.3; Piao, Z.4
关键词: hepatocellular carcinoma ; tumor ; suppressor gene ; methylation
刊名: HISTOLOGY AND HISTOPATHOLOGY
发表日期: 2008-10-01
卷: 23, 期:10, 页:1171-1175
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Pathology
研究领域[WOS]: Cell Biology ; Pathology
关键词[WOS]: MICROSATELLITE INSTABILITY ; INACTIVATION ; CANCER ; MEMBER
英文摘要:

The retinoblastoma protein-interacting zinc finger gene RIZ1 is a putative tumor suppressor gene, and the inactivation of the RIZ1 is frequently found in tumors through a loss of mRNA expression. In order to understand the role of RIZ1 inactivation in the tumorigenesis of hepatocellular carcinoma (HCC), we detected the RIZ1 promoter methylation status in 39 HCCs using a methylation specific PCR (MSP) method, and carried out LOH study with marker P704. We also assessed the associations between the methylation status and clinicopathological parameters, tumor size, tumor differentiation, and fractional allelic loss (FAL). The results showed that the RIZ1 promoter methylated both in advanced tumors (> 3 cm), (18/ 31, 58.0%) and in early tumors (< 3 cm), ( 4/ 8, 50.0%). There were 54.6% ( 12/ 22) tumors with hyper-methylation in the low FAL group and 45.5% (10/ 22) in the high FAL group. Moreover, the DNA methylation of the RIZ1 promoter was found not only in the poorly differentiated tumors (12/ 22, 54.6%), but also in the well differentiated tumors (10/ 22, 45.5%). Among the 22 HCCs (22/ 39, 56.4%) that showed hypermethylation at the RIZ1 promoter region, 3 cases showed biallelic methylation. Interestingly, one case showed hyper-methylation on one allele and a loss of heterozygosity (LOH) on the other allele. In other words, 4 HCCs showed the biallelic inactivation of the RIZ1. These results suggest that the inactivation of the RIZ1 by DNA methylation at its promoter region is involved in the tumorigenesis of HCC, particularly in the early stage of disease.

语种: 英语
WOS记录号: WOS:000258063300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51807
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Yanbian Univ, Dept Physiol, Coll Med, Yanji, Peoples R China
2.Peking Univ, Hosp 1, Dept Infect Dis, Beijing, Peoples R China
3.Yanbian Univ, Dept Pathol, Coll Med, Yanji, Peoples R China
4.Yanbian Social Mental Hosp, Dept Clin Pathol, Yanji, Peoples R China

Recommended Citation:
Piao, G-H.,Piao, W-H.,He, Y.,et al. Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma[J]. HISTOLOGY AND HISTOPATHOLOGY,2008,23(10):1171-1175.
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