IR@PKUHSC  > 北京大学第一临床医学院  > 感染疾病科
学科主题临床医学
Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma
Piao, G-H.1; Piao, W-H.2,3; He, Y.3; Zhang, H-H.3; Wang, G-Q.3; Piao, Z.4
关键词Hepatocellular Carcinoma Tumor Suppressor Gene Methylation
刊名HISTOLOGY AND HISTOPATHOLOGY
2008-10-01
23期:10页:1171-1175
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]MICROSATELLITE INSTABILITY ; INACTIVATION ; CANCER ; MEMBER
英文摘要

The retinoblastoma protein-interacting zinc finger gene RIZ1 is a putative tumor suppressor gene, and the inactivation of the RIZ1 is frequently found in tumors through a loss of mRNA expression. In order to understand the role of RIZ1 inactivation in the tumorigenesis of hepatocellular carcinoma (HCC), we detected the RIZ1 promoter methylation status in 39 HCCs using a methylation specific PCR (MSP) method, and carried out LOH study with marker P704. We also assessed the associations between the methylation status and clinicopathological parameters, tumor size, tumor differentiation, and fractional allelic loss (FAL). The results showed that the RIZ1 promoter methylated both in advanced tumors (> 3 cm), (18/ 31, 58.0%) and in early tumors (< 3 cm), ( 4/ 8, 50.0%). There were 54.6% ( 12/ 22) tumors with hyper-methylation in the low FAL group and 45.5% (10/ 22) in the high FAL group. Moreover, the DNA methylation of the RIZ1 promoter was found not only in the poorly differentiated tumors (12/ 22, 54.6%), but also in the well differentiated tumors (10/ 22, 45.5%). Among the 22 HCCs (22/ 39, 56.4%) that showed hypermethylation at the RIZ1 promoter region, 3 cases showed biallelic methylation. Interestingly, one case showed hyper-methylation on one allele and a loss of heterozygosity (LOH) on the other allele. In other words, 4 HCCs showed the biallelic inactivation of the RIZ1. These results suggest that the inactivation of the RIZ1 by DNA methylation at its promoter region is involved in the tumorigenesis of HCC, particularly in the early stage of disease.

语种英语
WOS记录号WOS:000258063300001
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51807
专题北京大学第一临床医学院_感染疾病科
作者单位1.Yanbian Univ, Dept Physiol, Coll Med, Yanji, Peoples R China
2.Peking Univ, Hosp 1, Dept Infect Dis, Beijing, Peoples R China
3.Yanbian Univ, Dept Pathol, Coll Med, Yanji, Peoples R China
4.Yanbian Social Mental Hosp, Dept Clin Pathol, Yanji, Peoples R China
推荐引用方式
GB/T 7714
Piao, G-H.,Piao, W-H.,He, Y.,et al. Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma[J]. HISTOLOGY AND HISTOPATHOLOGY,2008,23(10):1171-1175.
APA Piao, G-H.,Piao, W-H.,He, Y.,Zhang, H-H.,Wang, G-Q.,&Piao, Z..(2008).Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma.HISTOLOGY AND HISTOPATHOLOGY,23(10),1171-1175.
MLA Piao, G-H.,et al."Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma".HISTOLOGY AND HISTOPATHOLOGY 23.10(2008):1171-1175.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Piao, G-H.]的文章
[Piao, W-H.]的文章
[He, Y.]的文章
百度学术
百度学术中相似的文章
[Piao, G-H.]的文章
[Piao, W-H.]的文章
[He, Y.]的文章
必应学术
必应学术中相似的文章
[Piao, G-H.]的文章
[Piao, W-H.]的文章
[He, Y.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。