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Phenotypic analysis of the medullary-type CD4(-)CD8(+) thymocytes in mice
Tian, T1; Wang, HF1; Feng, MF1; Chen, WF1
关键词CD4(-)CD8(+) medullary-type thymocytes cell phenotype phenotypic differentiation
刊名CHINESE SCIENCE BULLETIN
2000-02-01
45期:3页:232-237
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]EXPRESSION ; IMMATURE ; MARKER ; THYMUS ; CELLS
英文摘要

Phenotypic analysis of the medullary-type CD4(-)CD8(+) (CD8SP) thymocytes has revealed phenotypic heterogeneity within this cell population. The phenotype of mature peripheral CD8(+)T cells is TCR alpha beta(+)CD3(+)Qa-2(+)HSA(-)3G11(-)6C10(-), whereas in the medullary-type CD8SP thymocytes, 20% are Qa-2(+); 33%, HAS(-); 30%, 3G11(-); and 70% are 6C10(-). The disparate expression patterns of these four cell surface markers suggest that medullary-type CD8SP thymocytes may undergo phenotypic maturation process. According to the distribution of these four cell surface markers, six subgroups of CD8SP thymocytes have been identified, The precursor-progeny relationship along with developmental pathway is postulated as follows: 6C10(+)HSA(+)3G11(-)Qa-2(-)-->6C10(+)HSA(+) 3G11(+)Qa-2(-)-->6C10(-)HSA(+)3G11(+)Qa-2(-)-->6C10(-)HSA(-)3G11(+)Qa-2(-)-->6C10(-)HSA(-)3G11Qa-2(-)-->6C10(-)HA S(-)3G11(-)Qa-2(+), the cells in the last subgroup exit the thymus and home into periphery.

语种英语
WOS记录号WOS:000085980500010
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51811
专题基础医学院_免疫学系
作者单位1.Beijing Med Univ, Dept Immunol, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Zool, Beijing 100080, Peoples R China
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Tian, T,Wang, HF,Feng, MF,et al. Phenotypic analysis of the medullary-type CD4(-)CD8(+) thymocytes in mice[J]. CHINESE SCIENCE BULLETIN,2000,45(3):232-237.
APA Tian, T,Wang, HF,Feng, MF,&Chen, WF.(2000).Phenotypic analysis of the medullary-type CD4(-)CD8(+) thymocytes in mice.CHINESE SCIENCE BULLETIN,45(3),232-237.
MLA Tian, T,et al."Phenotypic analysis of the medullary-type CD4(-)CD8(+) thymocytes in mice".CHINESE SCIENCE BULLETIN 45.3(2000):232-237.
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