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学科主题: 基础医学
题名:
Phenotypic analysis of the medullary-type CD4(-)CD8(+) thymocytes in mice
作者: Tian, T1; Wang, HF1; Feng, MF1; Chen, WF1
关键词: CD4(-)CD8(+) medullary-type thymocytes ; cell phenotype ; phenotypic differentiation
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2000-02-01
卷: 45, 期:3, 页:232-237
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: EXPRESSION ; IMMATURE ; MARKER ; THYMUS ; CELLS
英文摘要:

Phenotypic analysis of the medullary-type CD4(-)CD8(+) (CD8SP) thymocytes has revealed phenotypic heterogeneity within this cell population. The phenotype of mature peripheral CD8(+)T cells is TCR alpha beta(+)CD3(+)Qa-2(+)HSA(-)3G11(-)6C10(-), whereas in the medullary-type CD8SP thymocytes, 20% are Qa-2(+); 33%, HAS(-); 30%, 3G11(-); and 70% are 6C10(-). The disparate expression patterns of these four cell surface markers suggest that medullary-type CD8SP thymocytes may undergo phenotypic maturation process. According to the distribution of these four cell surface markers, six subgroups of CD8SP thymocytes have been identified, The precursor-progeny relationship along with developmental pathway is postulated as follows: 6C10(+)HSA(+)3G11(-)Qa-2(-)-->6C10(+)HSA(+) 3G11(+)Qa-2(-)-->6C10(-)HSA(+)3G11(+)Qa-2(-)-->6C10(-)HSA(-)3G11(+)Qa-2(-)-->6C10(-)HSA(-)3G11Qa-2(-)-->6C10(-)HA S(-)3G11(-)Qa-2(+), the cells in the last subgroup exit the thymus and home into periphery.

语种: 英语
WOS记录号: WOS:000085980500010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51811
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Beijing Med Univ, Dept Immunol, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Zool, Beijing 100080, Peoples R China

Recommended Citation:
Tian, T,Wang, HF,Feng, MF,et al. Phenotypic analysis of the medullary-type CD4(-)CD8(+) thymocytes in mice[J]. CHINESE SCIENCE BULLETIN,2000,45(3):232-237.
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