IR@PKUHSC  > 北京大学基础医学院  > 细胞生物学系
学科主题基础医学
Expression of LAPTM4B-35: A novel marker of progression, invasiveness and poor prognosis of extrahepatic cholanglocarcinoma
Zhou, Li1; He, Xiao-Dong1; Cui, Quan-Cai2; Zhou, Wei-Xun2; Qu, Qiang1; Zhou, Rou-Li3; Rui, Jing-An1; Yu, Jian-Chun1
关键词Lysosome-associated Protein Transmembrane-4 Beta Extrahepatic Cholangiocarcinoma Survival Resection
刊名CANCER LETTERS
2008-06-18
DOI10.1016/j.canlet.2008.01.025
264期:2页:209-217
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]BILE-DUCT CARCINOMA ; INTRAHEPATIC CHOLANGIOCARCINOMA ; CHOLANGIOCELLULAR CARCINOMA ; HEPATOCELLULAR-CARCINOMA ; SURGICAL-TREATMENT ; OVEREXPRESSION ; SURVIVAL ; RECURRENCE ; EXPERIENCE ; RESECTION
英文摘要

LAPTM4B was proven to overexpress in hepatocellular carcinoma and relate to differentiation. We immunohistochemically investigated the expression and potential clinicopathological and prognostic significance of LAPTM4B encoded protein, LAPTM4B-35, in extrahepatic cholangiocarcinoma (EHCC) for specimens from consecutive 81 patients. LAPTM4B-35 staining was positive in cancer tissues from 59 patients (72.8%), including 12 with score 1, 22 with score 2 and 25 with score 3. No positive staining was found in non-cancer epithelia. The staining score in cancer tissues was not only significantly associated with TNM staging, histological grade, perineural and lymph node invasion (P < 0.05), but also of comprehensive prognostic implications, including integrated estimation with CA19-9. These data established that LAPTM4B-35 positively expressed in a great portion of EHCC and might be a novel molecular maker of progression, invasiveness and poor prognosis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000256776900006
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被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51819
专题北京大学基础医学院_细胞生物学系
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gen Surg, Beijing 100032, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Pathol, Beijing 100032, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China
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Zhou, Li,He, Xiao-Dong,Cui, Quan-Cai,et al. Expression of LAPTM4B-35: A novel marker of progression, invasiveness and poor prognosis of extrahepatic cholanglocarcinoma[J]. CANCER LETTERS,2008,264(2):209-217.
APA Zhou, Li.,He, Xiao-Dong.,Cui, Quan-Cai.,Zhou, Wei-Xun.,Qu, Qiang.,...&Yu, Jian-Chun.(2008).Expression of LAPTM4B-35: A novel marker of progression, invasiveness and poor prognosis of extrahepatic cholanglocarcinoma.CANCER LETTERS,264(2),209-217.
MLA Zhou, Li,et al."Expression of LAPTM4B-35: A novel marker of progression, invasiveness and poor prognosis of extrahepatic cholanglocarcinoma".CANCER LETTERS 264.2(2008):209-217.
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