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学科主题: 基础医学
题名:
Expression of LAPTM4B-35: A novel marker of progression, invasiveness and poor prognosis of extrahepatic cholanglocarcinoma
作者: Zhou, Li1; He, Xiao-Dong1; Cui, Quan-Cai2; Zhou, Wei-Xun2; Qu, Qiang1; Zhou, Rou-Li3; Rui, Jing-An1; Yu, Jian-Chun1
关键词: lysosome-associated protein transmembrane-4 beta ; extrahepatic cholangiocarcinoma ; survival ; resection
刊名: CANCER LETTERS
发表日期: 2008-06-18
DOI: 10.1016/j.canlet.2008.01.025
卷: 264, 期:2, 页:209-217
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: BILE-DUCT CARCINOMA ; INTRAHEPATIC CHOLANGIOCARCINOMA ; CHOLANGIOCELLULAR CARCINOMA ; HEPATOCELLULAR-CARCINOMA ; SURGICAL-TREATMENT ; OVEREXPRESSION ; SURVIVAL ; RECURRENCE ; EXPERIENCE ; RESECTION
英文摘要:

LAPTM4B was proven to overexpress in hepatocellular carcinoma and relate to differentiation. We immunohistochemically investigated the expression and potential clinicopathological and prognostic significance of LAPTM4B encoded protein, LAPTM4B-35, in extrahepatic cholangiocarcinoma (EHCC) for specimens from consecutive 81 patients. LAPTM4B-35 staining was positive in cancer tissues from 59 patients (72.8%), including 12 with score 1, 22 with score 2 and 25 with score 3. No positive staining was found in non-cancer epithelia. The staining score in cancer tissues was not only significantly associated with TNM staging, histological grade, perineural and lymph node invasion (P < 0.05), but also of comprehensive prognostic implications, including integrated estimation with CA19-9. These data established that LAPTM4B-35 positively expressed in a great portion of EHCC and might be a novel molecular maker of progression, invasiveness and poor prognosis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000256776900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51819
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gen Surg, Beijing 100032, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Pathol, Beijing 100032, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China

Recommended Citation:
Zhou, Li,He, Xiao-Dong,Cui, Quan-Cai,et al. Expression of LAPTM4B-35: A novel marker of progression, invasiveness and poor prognosis of extrahepatic cholanglocarcinoma[J]. CANCER LETTERS,2008,264(2):209-217.
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