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学科主题: 临床医学
题名:
HOXA13 Promotes Cancer Cell Growth and Predicts Poor Survival of Patients with Esophageal Squamous Cell Carcinoma
作者: Gu, Zhen-Dong1; Shen, Lu-Yan1; Wang, Hua1; Chen, Xiao-Mei3; Li, Yong2; Ning, Tao2; Chen, Ke-Neng1
刊名: CANCER RESEARCH
发表日期: 2009-06-15
DOI: 10.1158/0008-5472.CAN-08-4546
卷: 69, 期:12, 页:4969-4973
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GENE-EXPRESSION ; SUBCELLULAR-LOCALIZATION ; NUCLEAR EXPORT ; ACTIN ; MORPHOGENESIS ; DROSOPHILA ; LEUKEMIA ; HEDGEHOG ; BINDING ; CLUSTER
英文摘要:

Homeobox genes are known to be classic examples of the intimate relationship between embryogenesis and tumorigenesis. Here, we investigated whether inhibition of HOXA13, a member of the homeobox genes, was sufficient to affect the proliferation of esophageal cancer cells in vitro and in vivo, and studied the association between HOXA13 expression and survival of patients with esophageal squamous cell carcinoma (ESCC). HOXA13 expression was permanently knocked down using an RNA interference technique, and cell strain with stable knockdown of HOXA13 protein was established. Colony formation assay showed that the number of colonies in HOXA13 protein-deficient cells was significantly less than that of control cells (P<0.01). Tumor growth in nude mice showed that the weight and volume of tumors from the HOXA13 knockdown cells was significantly less than that from the control cells (P<0.01). Then, HOXA13 expression in ESCC specimens and paired noncancerous mucosa was detected by immunohistochemistry, and overexpression of HOXA13 was found to be more pronounced in ESCCs than paired noncancerous mucosa (P<0.05). Furthermore, the association of HOXA13 expression and disease-free survival time was analyzed in 155 ESCC cases. The median survival time of patients expressing HOXA13 was significantly shorter than HOXA13-negative patients (P=0.0006). Multivariate analysis indicated that tumor-node-metastasis (TNM) stage and HOYA13 expression were independent predictors of disease-free survival time of patients with ESCC. Our results showed that HOXA13 expression enhanced tumor growth in vitro and in vivo, and was a negative independent predictor of disease-free survival of patients with ESCC. [Cancer Res 2009;69(12):4969-73]

语种: 英语
所属项目编号: 30572130 ; 2005-2020
项目资助者: National Natural Science Foundation of China ; Capital Medical Development Research Fund
WOS记录号: WOS:000267506400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51823
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Minist Educ,Dept Thorac Surg 1,Key Lab Carcinogen, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Minist Educ, Key Lab Carcinogenesis & Translat Res,Dept Genet, Beijing 100036, Peoples R China
3.Fujian Med Univ, Union Hosp, Dept Gynecol & Obstet, Fuzhou, Peoples R China

Recommended Citation:
Gu, Zhen-Dong,Shen, Lu-Yan,Wang, Hua,et al. HOXA13 Promotes Cancer Cell Growth and Predicts Poor Survival of Patients with Esophageal Squamous Cell Carcinoma[J]. CANCER RESEARCH,2009,69(12):4969-4973.
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