学科主题基础医学
Huang Qi Jian Zhong Pellet Attenuates TNBS-Induced Colitis in Rats via Mechanisms Involving Improvement of Energy Metabolism
Liu, Duan-Yong1,2; Pan, Chun-Shui2; Liu, Yu-Ying2; Wei, Xiao-Hong2; Zhou, Chang-Man2; Sun, Kai2; He, Ke2; Li, Chong2; Yan, Li2; Fan, Jing-Yu2; Wang, Chuan-She2,3,4,5; Hibi, Toshifumi6; Liu, Hong-Ning1,7; Han, Jing-Yan2,3,4,5,6
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2013
DOI10.1155/2013/574629
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]INFLAMMATORY-BOWEL-DISEASE ; ULCERATIVE-COLITIS ; JUNCTION PROTEINS ; RHO-KINASE ; CEREBRALCARE GRANULE(R) ; ISCHEMIA-REPERFUSION ; ENDOTHELIAL-CELLS ; CROHNS-DISEASE ; LUNG INJURY ; BLOOD-FLOW
英文摘要

Huang Qi Jian Zhong Pellet (HQJZ) is a famous Chinese medicine formula for treatment of various gastrointestinal tract diseases. This study investigated the role of HQJZ in 2,4,6-trinitrobenzene sulfonic acid- (TNBS-) induced colitis and its underlying mechanism. Colonic mucosal injury was induced by TNBS in the Sprague-Dawley rats. In the HQJZ treatment group, HQJZ was administered (2 g/kg) for 14 days starting from day 1 after TNBS infusion. Colonic mucosal injury occurred obviously 1 day after TNBS challenge and did not recover distinctively until day 15, including an increase in macro-and microscopic scores, a colonic weight index, a decrease in colonic length, a number of functional capillaries, and blood flow. Inverted intravital microscopy and ELISA showed colonic microcirculatory disturbances and inflammatory responses after TNBS stimulation, respectively. TNBS decreased occludin, RhoA, and ROCK-I, while increasing Rac-1, PAK-1, and phosphorylated myosin light chain. In addition, ATP content and ATP5D expression in colonic mucosa decreased after TNBS challenge. Impressively, treatment with HQJZ significantly attenuated all of the alterations evoked by TNBS, promoting the recovery of colonic injury. The present study demonstrated HQJZ as a multitargeting management for colonic mucosal injury, which set in motion mechanisms involving improvement of energy metabolism.

语种英语
WOS记录号WOS:000320541100001
项目编号2008ZX09401
资助机构Production of New Medicine Program of the Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51824
专题北京大学基础医学院_北大医学部天士力微循环研究中心
北京大学基础医学院
作者单位1.Jiangxi Univ Tradit Chinese Med, Nanchang 330004, Jiangxi, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Anat, Beijing 100191, Peoples R China
5.State Adm Tradit Chinese Med, Key Lab Microcirculat, Beijing 100191, Peoples R China
6.Keio Univ, Sch Med, Dept Internal Med, Tokyo 1608582, Japan
7.Jiangxi Univ TCM, Minist Educ, Key Lab Modern Preparat TCM, Nanchang 330004, Jiangxi, Peoples R China
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GB/T 7714
Liu, Duan-Yong,Pan, Chun-Shui,Liu, Yu-Ying,et al. Huang Qi Jian Zhong Pellet Attenuates TNBS-Induced Colitis in Rats via Mechanisms Involving Improvement of Energy Metabolism[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Liu, Duan-Yong.,Pan, Chun-Shui.,Liu, Yu-Ying.,Wei, Xiao-Hong.,Zhou, Chang-Man.,...&Han, Jing-Yan.(2013).Huang Qi Jian Zhong Pellet Attenuates TNBS-Induced Colitis in Rats via Mechanisms Involving Improvement of Energy Metabolism.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Liu, Duan-Yong,et al."Huang Qi Jian Zhong Pellet Attenuates TNBS-Induced Colitis in Rats via Mechanisms Involving Improvement of Energy Metabolism".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
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