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学科主题: 基础医学
题名:
Huang Qi Jian Zhong Pellet Attenuates TNBS-Induced Colitis in Rats via Mechanisms Involving Improvement of Energy Metabolism
作者: Liu, Duan-Yong1,2; Pan, Chun-Shui2; Liu, Yu-Ying2; Wei, Xiao-Hong2; Zhou, Chang-Man2; Sun, Kai2; He, Ke2; Li, Chong2; Yan, Li2; Fan, Jing-Yu2; Wang, Chuan-She2,3,4,5; Hibi, Toshifumi6; Liu, Hong-Ning1,7; Han, Jing-Yan2,3,4,5,6
刊名: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2013
DOI: 10.1155/2013/574629
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: INFLAMMATORY-BOWEL-DISEASE ; ULCERATIVE-COLITIS ; JUNCTION PROTEINS ; RHO-KINASE ; CEREBRALCARE GRANULE(R) ; ISCHEMIA-REPERFUSION ; ENDOTHELIAL-CELLS ; CROHNS-DISEASE ; LUNG INJURY ; BLOOD-FLOW
英文摘要:

Huang Qi Jian Zhong Pellet (HQJZ) is a famous Chinese medicine formula for treatment of various gastrointestinal tract diseases. This study investigated the role of HQJZ in 2,4,6-trinitrobenzene sulfonic acid- (TNBS-) induced colitis and its underlying mechanism. Colonic mucosal injury was induced by TNBS in the Sprague-Dawley rats. In the HQJZ treatment group, HQJZ was administered (2 g/kg) for 14 days starting from day 1 after TNBS infusion. Colonic mucosal injury occurred obviously 1 day after TNBS challenge and did not recover distinctively until day 15, including an increase in macro-and microscopic scores, a colonic weight index, a decrease in colonic length, a number of functional capillaries, and blood flow. Inverted intravital microscopy and ELISA showed colonic microcirculatory disturbances and inflammatory responses after TNBS stimulation, respectively. TNBS decreased occludin, RhoA, and ROCK-I, while increasing Rac-1, PAK-1, and phosphorylated myosin light chain. In addition, ATP content and ATP5D expression in colonic mucosa decreased after TNBS challenge. Impressively, treatment with HQJZ significantly attenuated all of the alterations evoked by TNBS, promoting the recovery of colonic injury. The present study demonstrated HQJZ as a multitargeting management for colonic mucosal injury, which set in motion mechanisms involving improvement of energy metabolism.

语种: 英语
所属项目编号: 2008ZX09401
项目资助者: Production of New Medicine Program of the Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000320541100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51824
Appears in Collections:基础医学院_北大医学部天士力微循环研究中心_期刊论文

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作者单位: 1.Jiangxi Univ Tradit Chinese Med, Nanchang 330004, Jiangxi, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Anat, Beijing 100191, Peoples R China
5.State Adm Tradit Chinese Med, Key Lab Microcirculat, Beijing 100191, Peoples R China
6.Keio Univ, Sch Med, Dept Internal Med, Tokyo 1608582, Japan
7.Jiangxi Univ TCM, Minist Educ, Key Lab Modern Preparat TCM, Nanchang 330004, Jiangxi, Peoples R China

Recommended Citation:
Liu, Duan-Yong,Pan, Chun-Shui,Liu, Yu-Ying,et al. Huang Qi Jian Zhong Pellet Attenuates TNBS-Induced Colitis in Rats via Mechanisms Involving Improvement of Energy Metabolism[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
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