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Synthesis and bioactivities of two multiple antigen peptides as potential vaccine against schistosoma
Huang, HQ1; Li, SC1; Qin, ZH1; Cao, SL1; Yao, Y1; Liu, YS1; Li, HY1; Cai, MS1; Li, ZJ1; Shi, YE1
关键词Schistosomiasis Synthetic Peptide Vaccine Multiple Antigenic Peptides
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2005-05-02
DOI10.1016/j.bmcl.2005.01.040
15期:9页:2415-2419
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]PROSPECTS
英文摘要

Based on the two antigenic peptides, 26-43 (P-26) and 116-131 (PI 16), derived from 28 kDa glutathione S-transferase of Schistosoma mansoni (Sm28GST), two multiple antigenic peptides (MAPs), (P-26)(4)-MAP and (P-116)(4)-MAP with the same oligomeric lysine core, were synthesized by stepwise solid-phase peptide synthesis method. The antigenicities and protective effects of these two MAPs were examined on experimental animals. As shown in the dot-ELISA result, the synthetic MAPs could be recognized and bound by immunoglobins in both patient′s and infected-rabbit′s sera. After Kunming mice were immunized with (P-26)(4)-MAP, the worm burden reduction rate and the liver egg reduction rate were 59.9% and 61.1%. In (P-26)(4)-MAP or (P-116)(4)-MAP immunized BALB/c mice, the worm burden reduction rates were 37.5% and 62.5%, respectively, and the liver egg reduction rates were 35.1% and 54.0%, respectively. (c) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000228888200044
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51825
专题北京大学药学院_化学生物学系
北京大学第二临床医学院_肾内科
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
2.Tongji Med Coll, Sch Basic Med Sci, Wuhan 430030, Peoples R China
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GB/T 7714
Huang, HQ,Li, SC,Qin, ZH,et al. Synthesis and bioactivities of two multiple antigen peptides as potential vaccine against schistosoma[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2005,15(9):2415-2419.
APA Huang, HQ.,Li, SC.,Qin, ZH.,Cao, SL.,Yao, Y.,...&Shi, YE.(2005).Synthesis and bioactivities of two multiple antigen peptides as potential vaccine against schistosoma.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,15(9),2415-2419.
MLA Huang, HQ,et al."Synthesis and bioactivities of two multiple antigen peptides as potential vaccine against schistosoma".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15.9(2005):2415-2419.
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