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学科主题: 药学
题名:
Synthesis and bioactivities of two multiple antigen peptides as potential vaccine against schistosoma
作者: Huang, HQ1; Li, SC1; Qin, ZH1; Cao, SL1; Yao, Y1; Liu, YS1; Li, HY1; Cai, MS1; Li, ZJ1; Shi, YE1
关键词: schistosomiasis ; synthetic peptide vaccine ; multiple antigenic peptides
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2005-05-02
DOI: 10.1016/j.bmcl.2005.01.040
卷: 15, 期:9, 页:2415-2419
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: PROSPECTS
英文摘要:

Based on the two antigenic peptides, 26-43 (P-26) and 116-131 (PI 16), derived from 28 kDa glutathione S-transferase of Schistosoma mansoni (Sm28GST), two multiple antigenic peptides (MAPs), (P-26)(4)-MAP and (P-116)(4)-MAP with the same oligomeric lysine core, were synthesized by stepwise solid-phase peptide synthesis method. The antigenicities and protective effects of these two MAPs were examined on experimental animals. As shown in the dot-ELISA result, the synthetic MAPs could be recognized and bound by immunoglobins in both patient′s and infected-rabbit′s sera. After Kunming mice were immunized with (P-26)(4)-MAP, the worm burden reduction rate and the liver egg reduction rate were 59.9% and 61.1%. In (P-26)(4)-MAP or (P-116)(4)-MAP immunized BALB/c mice, the worm burden reduction rates were 37.5% and 62.5%, respectively, and the liver egg reduction rates were 35.1% and 54.0%, respectively. (c) 2005 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000228888200044
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51825
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
2.Tongji Med Coll, Sch Basic Med Sci, Wuhan 430030, Peoples R China

Recommended Citation:
Huang, HQ,Li, SC,Qin, ZH,et al. Synthesis and bioactivities of two multiple antigen peptides as potential vaccine against schistosoma[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2005,15(9):2415-2419.
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