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ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects
Wang RuoQi1; Zhou DongHao2; Xi Bo3; Ge XiuShan4; Zhu Ping5; Wang Bo6; Zhou MingAi7; Huang YuBei8; Liu JunTing9; Yu Yang10; Wang ChunYu10,11
关键词Ectonucleotide Pyrophosphatase /phosphodiesterase 1 (Enpp1) Plasma Cell Membrane Glycoprotein 1 (Pc1) K121q Single Nucleotide Polymorphism (Snp) Obesity
刊名BIOMEDICAL AND ENVIRONMENTAL SCIENCES
2011-04-01
DOI10.3967/0895-3988.2011.02.015
24期:2页:200-206
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]INSULIN-RESISTANCE ; ETHNIC-DIFFERENCES ; TYPE-2 ; PC-1 ; VARIANTS ; RISK
英文摘要

Objective Findings from the previous studies have suggested a relationship between ectonucleotide pyrophosphatase /phosphodiesterase 1 (ENPP-1) or plasma cell membrane glycoprotein 1 (PC-1) gene single nucleotide polymorphism (K121Q., rs1044498) and genetic susceptibility to obesity. However, such relationship is not reproduced by some currently available studies. In this context, the present study is aimed to quantitatively analyze the association of K121Q variant with obesity in all published case-control studies in European adult populations.

Methods Published literature from PubMed, EMBASE, and ISI web of science databases were retrieved. The studies evaluating the association of ENPP1/PC1 gene K121Q polymorphism with obesity were included, in which sufficient data were presented to calculate the odds ratio (OR) with 95% confidence intervals (CIs).

Results Ten case-control studies meeting the inclusion criteria identified a total of 24,324 subjects including 11,372 obese and 12,952 control subjects. The meta-analysis results showed a statistically significant association of K121Q with obesity [OR (95% CI): 1.25 (1.04-1.52) P=0.021] under a recessive model of inheritance (QQ vs. KK+KQ) without heterogeneity or publication bias.

Conclusions The results from the present study have indicated that ENPP1/PC1 Q121 variant may increase the risk of obesity and that more well-designed studies based on a larger population will be required to further evaluate the role of ENPP1/PC1 gene K121Q polymorphism in obesity and other related metabolic syndromes.

语种英语
WOS记录号WOS:000290706000015
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51829
专题北京大学公共卫生学院
作者单位1.Youjiang Med Coll Nationalities, Affiliated Hosp, Dept Cardiol, Baise 533000, Guangxi, Peoples R China
2.Linyi Peoples Hosp, Dept Endocrinol, Linyi 276002, Shandong, Peoples R China
3.Shandong Univ, Sch Publ Hlth, Dept Maternal & Child Hlth Care, Jinan 250012, Shandong, Peoples R China
4.Capital Inst Pediat, Dept Genet, Beijing 100020, Peoples R China
5.Guangdong Acad Med Sci, Guangdong Gen Hosp, Guangdong Cardiovasc Inst, Guangzhou 510100, Guangdong, Peoples R China
6.Chinese Acad Med Sci, Beijing 100730, Peoples R China
7.Linyi Hosp Tradit Chinese Med, Dept Internal Med, Linyi 276002, Shandong, Peoples R China
8.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100083, Peoples R China
9.Capital Inst Pediat, Dept Epidemiol, Beijing 100020, Peoples R China
10.Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
11.Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
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GB/T 7714
Wang RuoQi,Zhou DongHao,Xi Bo,et al. ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2011,24(2):200-206.
APA Wang RuoQi.,Zhou DongHao.,Xi Bo.,Ge XiuShan.,Zhu Ping.,...&Wang ChunYu.(2011).ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,24(2),200-206.
MLA Wang RuoQi,et al."ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 24.2(2011):200-206.
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