北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 药理学系  > 期刊论文
学科主题: 基础医学
题名:
Diltiazem potentiates pentobarbital-induced hypnosis via 5-HT1A and 5-HT2A/2C receptors: Role for dorsal raphe nucleus
作者: Cui, Su-Ying; Cui, Xiang-Yu; Zhang, Juan; Wang, Zi-Jun; Yu, Bin; Sheng, Zhao-Fu; Zhang, Xue-Qiong; Shi, Xiao-Lei; Zhang, Yong-He
关键词: Dorsal raphe nucleus ; Pentobarbital ; Hypnosis ; Diltiazem ; 5-HT1A receptor ; 5-HT2A/2C receptor
刊名: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
发表日期: 2011-10-01
DOI: 10.1016/j.pbb.2011.06.001
卷: 99, 期:4, 页:566-572
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: SLEEP-WAKING CYCLE ; SEROTONERGIC SYSTEM ; MICRODIALYSIS PERFUSION ; CHANNEL BLOCKERS ; C-FOS ; RAT ; WAKEFULNESS ; ANESTHESIA ; NEURONS ; 8-OH-DPAT
英文摘要:

It has been reported that the sedative component of pentobarbital is mediated by GABA receptors in an endogenous sleep pathway and the ventrolateral preoptic area (VLPO)-tuberomammillary nucleus (TMN) or VLPO-dorsal raphe nucleus (DRN) neural circuit is important in the sedative response to pentobarbital. Our previous findings indicated that the VLPO-TMN neuronal circuit may play crucial part in the augmentative effect of diltiazem on pentobarbital sleep and the serotonergic system may be involved. This study was designed to investigate the role of DRN and the serotonergic receptors 5-HT1A and 5-HT2A/2C in the augmentative effect of diltiazem on pentobarbital-induced hypnosis in rats. The results showed that diltiazem (5 mg/kg, i.g.) significantly reversed pentobarbital-induced (35 mg/kg, i.p.) reduction of c-Fos expression in 5-HT neurons of DRNV (at - 7.5 mm Bregma), DRND, DRNVL and MRN (at - 8.0 mm Bregma). However it did not influence this reducing effect of pentobarbital on non-5-HT neurons either in DRN or in MRN. Moreover, the effect of diltiazem (1 or 2 mg/kg, i.g.) on pentobarbital-induced (35 mg/kg. i.p.) hypnosis was significantly inhibited by 5-HT1A agonist 8-OH-DPAT (0.5 mg/kg, i.p.) and 5-HT2A/2C agonist DOI (0.5 mg/kg, i.p.), and potentiated by 5-HT1A antagonist p-MPPI (2 mg/kg, i.p.) and 5-HT2A/2C antagonist ritanserin (2 mg/kg, i.p.), respectively. From these results, it should be presumed that the augmentative effect of diltiazem on pentobarbital-induced sleep may be related to 5-HT1A and 5-HT2A/2C receptors, and DRN may be involved. In addition, it also suggested that the DRN may play a multi-modulating role in sleep-wake regulation rather than being recognized simply as arousal nuclei. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2009ZX09103-124 ; 30640070 ; 30772556 ; 20100001110048
项目资助者: National Scientific and Technological major special project ; National Natural Science Foundation of China ; Ministry of Education of China ; Peking University
WOS记录号: WOS:000294880100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51832
Appears in Collections:基础医学院_药理学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China

Recommended Citation:
Cui, Su-Ying,Cui, Xiang-Yu,Zhang, Juan,et al. Diltiazem potentiates pentobarbital-induced hypnosis via 5-HT1A and 5-HT2A/2C receptors: Role for dorsal raphe nucleus[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2011,99(4):566-572.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Cui, Su-Ying]'s Articles
[Cui, Xiang-Yu]'s Articles
[Zhang, Juan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Cui, Su-Ying]‘s Articles
[Cui, Xiang-Yu]‘s Articles
[Zhang, Juan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace