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Diltiazem potentiates pentobarbital-induced hypnosis via 5-HT1A and 5-HT2A/2C receptors: Role for dorsal raphe nucleus
Cui, Su-Ying; Cui, Xiang-Yu; Zhang, Juan; Wang, Zi-Jun; Yu, Bin; Sheng, Zhao-Fu; Zhang, Xue-Qiong; Shi, Xiao-Lei; Zhang, Yong-He
关键词Dorsal Raphe Nucleus Pentobarbital Hypnosis Diltiazem 5-ht1a Receptor 5-ht2a/2c Receptor
刊名PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
2011-10-01
DOI10.1016/j.pbb.2011.06.001
99期:4页:566-572
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
资助者National Scientific and Technological major special project ; National Natural Science Foundation of China ; Ministry of Education of China ; Peking University ; National Scientific and Technological major special project ; National Natural Science Foundation of China ; Ministry of Education of China ; Peking University
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]SLEEP-WAKING CYCLE ; SEROTONERGIC SYSTEM ; MICRODIALYSIS PERFUSION ; CHANNEL BLOCKERS ; C-FOS ; RAT ; WAKEFULNESS ; ANESTHESIA ; NEURONS ; 8-OH-DPAT
英文摘要

It has been reported that the sedative component of pentobarbital is mediated by GABA receptors in an endogenous sleep pathway and the ventrolateral preoptic area (VLPO)-tuberomammillary nucleus (TMN) or VLPO-dorsal raphe nucleus (DRN) neural circuit is important in the sedative response to pentobarbital. Our previous findings indicated that the VLPO-TMN neuronal circuit may play crucial part in the augmentative effect of diltiazem on pentobarbital sleep and the serotonergic system may be involved. This study was designed to investigate the role of DRN and the serotonergic receptors 5-HT1A and 5-HT2A/2C in the augmentative effect of diltiazem on pentobarbital-induced hypnosis in rats. The results showed that diltiazem (5 mg/kg, i.g.) significantly reversed pentobarbital-induced (35 mg/kg, i.p.) reduction of c-Fos expression in 5-HT neurons of DRNV (at - 7.5 mm Bregma), DRND, DRNVL and MRN (at - 8.0 mm Bregma). However it did not influence this reducing effect of pentobarbital on non-5-HT neurons either in DRN or in MRN. Moreover, the effect of diltiazem (1 or 2 mg/kg, i.g.) on pentobarbital-induced (35 mg/kg. i.p.) hypnosis was significantly inhibited by 5-HT1A agonist 8-OH-DPAT (0.5 mg/kg, i.p.) and 5-HT2A/2C agonist DOI (0.5 mg/kg, i.p.), and potentiated by 5-HT1A antagonist p-MPPI (2 mg/kg, i.p.) and 5-HT2A/2C antagonist ritanserin (2 mg/kg, i.p.), respectively. From these results, it should be presumed that the augmentative effect of diltiazem on pentobarbital-induced sleep may be related to 5-HT1A and 5-HT2A/2C receptors, and DRN may be involved. In addition, it also suggested that the DRN may play a multi-modulating role in sleep-wake regulation rather than being recognized simply as arousal nuclei. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
所属项目编号2009ZX09103-124 ; 30640070 ; 30772556 ; 20100001110048
资助者National Scientific and Technological major special project ; National Natural Science Foundation of China ; Ministry of Education of China ; Peking University ; National Scientific and Technological major special project ; National Natural Science Foundation of China ; Ministry of Education of China ; Peking University
WOS记录号WOS:000294880100007
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51832
专题基础医学院_药理学系
作者单位Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China
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GB/T 7714
Cui, Su-Ying,Cui, Xiang-Yu,Zhang, Juan,et al. Diltiazem potentiates pentobarbital-induced hypnosis via 5-HT1A and 5-HT2A/2C receptors: Role for dorsal raphe nucleus[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2011,99(4):566-572.
APA Cui, Su-Ying.,Cui, Xiang-Yu.,Zhang, Juan.,Wang, Zi-Jun.,Yu, Bin.,...&Zhang, Yong-He.(2011).Diltiazem potentiates pentobarbital-induced hypnosis via 5-HT1A and 5-HT2A/2C receptors: Role for dorsal raphe nucleus.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,99(4),566-572.
MLA Cui, Su-Ying,et al."Diltiazem potentiates pentobarbital-induced hypnosis via 5-HT1A and 5-HT2A/2C receptors: Role for dorsal raphe nucleus".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 99.4(2011):566-572.
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