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学科主题: 临床医学
题名:
Cholinergic Synaptic Transmissions Were Altered after Single Sevoflurane Exposure in Drosophila Pupa
作者: Chen, Rongfa1; Zhang, Tao2; Kuang, Liting2; Chen, Zhen2; Ran, Dongzhi3; Niu, Yang4; Xu, Kangqing2; Gu, Huaiyu3
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2015
DOI: 10.1155/2015/485709
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: DEVELOPING BRAIN ; RATS ; NEURONS ; MEMORY ; NEURODEGENERATION ; PLASTICITY ; ISOFLURANE ; ANESTHESIA ; DEFICITS
英文摘要:

Purpose. Sevoflurane, one of the most used general anesthetics, is widely used in clinical practice all over the world. Previous studies indicated that sevoflurane could induce neuron apoptosis and neural deficit causing query in the safety of anesthesia using sevoflurane. The present study was designed to investigate the effects of sevoflurane on electrophysiology in Drosophila pupa whose excitatory neurotransmitter is acetylcholine early after sevoflurane exposure using whole brain recording technique. Methods. Wide types of Drosophila (canton-s flies) were allocated to control and sevoflurane groups randomly. Sevoflurane groups (1% sevoflurane; 2% sevoflurane; 3% sevoflurane) were exposed to sevoflurane and the exposure lasted 5 hours, respectively. All flies were subjected to electrophysiology experiment using patch clamp 24 hours after exposure. Results. The results showed that, 24 hours after sevoflurane exposure, frequency but not the amplitude of miniature excitatory postsynaptic currents (mEPSCs) was significantly reduced (P < 0.05). Furthermore, we explored the underlying mechanism and found that calcium currents density, which partially regulated the frequency of mEPSCs, was significantly reduced after sevoflurane exposure (P < 0.05). Conclusions. All these suggested that sevoflurane could alter the mEPSCs that are related to synaptic plasticity partially through modulating calcium channel early after sevoflurane exposure.

语种: 英语
WOS记录号: WOS:000349692300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51834
Appears in Collections:北京大学深圳医院_麻醉科_期刊论文

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作者单位: 1.Peking Univ, Dept Anesthesiol, Shenzhen Hosp, Shenzhen 518000, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Anesthesiol, Guangzhou 510080, Guangdong, Peoples R China
3.Sun Yat Sen Univ, Zhongshan Sch Med, Dept Anat & Neurobiol, Guangzhou 510080, Guangdong, Peoples R China
4.Shanghai First Peoples Hosp, Dept Rehabil, Shanghai 201620, Peoples R China

Recommended Citation:
Chen, Rongfa,Zhang, Tao,Kuang, Liting,et al. Cholinergic Synaptic Transmissions Were Altered after Single Sevoflurane Exposure in Drosophila Pupa[J]. BIOMED RESEARCH INTERNATIONAL,2015.
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