IR@PKUHSC  > 北京大学深圳医院  > 麻醉科
学科主题临床医学
Cholinergic Synaptic Transmissions Were Altered after Single Sevoflurane Exposure in Drosophila Pupa
Chen, Rongfa1; Zhang, Tao2; Kuang, Liting2; Chen, Zhen2; Ran, Dongzhi3; Niu, Yang4; Xu, Kangqing2; Gu, Huaiyu3
刊名BIOMED RESEARCH INTERNATIONAL
2015
DOI10.1155/2015/485709
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]DEVELOPING BRAIN ; RATS ; NEURONS ; MEMORY ; NEURODEGENERATION ; PLASTICITY ; ISOFLURANE ; ANESTHESIA ; DEFICITS
英文摘要

Purpose. Sevoflurane, one of the most used general anesthetics, is widely used in clinical practice all over the world. Previous studies indicated that sevoflurane could induce neuron apoptosis and neural deficit causing query in the safety of anesthesia using sevoflurane. The present study was designed to investigate the effects of sevoflurane on electrophysiology in Drosophila pupa whose excitatory neurotransmitter is acetylcholine early after sevoflurane exposure using whole brain recording technique. Methods. Wide types of Drosophila (canton-s flies) were allocated to control and sevoflurane groups randomly. Sevoflurane groups (1% sevoflurane; 2% sevoflurane; 3% sevoflurane) were exposed to sevoflurane and the exposure lasted 5 hours, respectively. All flies were subjected to electrophysiology experiment using patch clamp 24 hours after exposure. Results. The results showed that, 24 hours after sevoflurane exposure, frequency but not the amplitude of miniature excitatory postsynaptic currents (mEPSCs) was significantly reduced (P < 0.05). Furthermore, we explored the underlying mechanism and found that calcium currents density, which partially regulated the frequency of mEPSCs, was significantly reduced after sevoflurane exposure (P < 0.05). Conclusions. All these suggested that sevoflurane could alter the mEPSCs that are related to synaptic plasticity partially through modulating calcium channel early after sevoflurane exposure.

语种英语
WOS记录号WOS:000349692300001
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51834
专题北京大学深圳医院_麻醉科
作者单位1.Peking Univ, Dept Anesthesiol, Shenzhen Hosp, Shenzhen 518000, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Anesthesiol, Guangzhou 510080, Guangdong, Peoples R China
3.Sun Yat Sen Univ, Zhongshan Sch Med, Dept Anat & Neurobiol, Guangzhou 510080, Guangdong, Peoples R China
4.Shanghai First Peoples Hosp, Dept Rehabil, Shanghai 201620, Peoples R China
推荐引用方式
GB/T 7714
Chen, Rongfa,Zhang, Tao,Kuang, Liting,et al. Cholinergic Synaptic Transmissions Were Altered after Single Sevoflurane Exposure in Drosophila Pupa[J]. BIOMED RESEARCH INTERNATIONAL,2015.
APA Chen, Rongfa.,Zhang, Tao.,Kuang, Liting.,Chen, Zhen.,Ran, Dongzhi.,...&Gu, Huaiyu.(2015).Cholinergic Synaptic Transmissions Were Altered after Single Sevoflurane Exposure in Drosophila Pupa.BIOMED RESEARCH INTERNATIONAL.
MLA Chen, Rongfa,et al."Cholinergic Synaptic Transmissions Were Altered after Single Sevoflurane Exposure in Drosophila Pupa".BIOMED RESEARCH INTERNATIONAL (2015).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Rongfa]的文章
[Zhang, Tao]的文章
[Kuang, Liting]的文章
百度学术
百度学术中相似的文章
[Chen, Rongfa]的文章
[Zhang, Tao]的文章
[Kuang, Liting]的文章
必应学术
必应学术中相似的文章
[Chen, Rongfa]的文章
[Zhang, Tao]的文章
[Kuang, Liting]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。