IR@PKUHSC  > 北京大学第三临床医学院  > 骨科
学科主题临床医学
Single-Dose Local Simvastatin Injection Improves Implant Fixation via Increased Angiogenesis and Bone Formation in an Ovariectomized Rat Model
Tan, Jie1,2; Yang, Ning1; Fu, Xin1,2; Cui, Yueyi1; Guo, Qi3; Ma, Teng1; Yin, Xiaoxue1,2; Leng, Huijie1,2; Song, Chunli1,2
关键词Angiogenesis Inducing Agents Osseointegration Osteoporosis Simvastatin
刊名MEDICAL SCIENCE MONITOR
2015-05-18
DOI10.12659/MSM.892247
21页:1428-1439
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]TOTAL HIP-ARTHROPLASTY ; CONJUGATED GELATIN HYDROGEL ; TITANIUM IMPLANTS ; OSTEOPOROTIC RATS ; DRUG-DELIVERY ; FOLLOW-UP ; BISPHOSPHONATE ; OSTEOGENESIS ; STABILITY ; STATINS
英文摘要

Background: Statins have been reported to promote bone formation. However, taken orally, their bioavailability is low to the bones. Implant therapies require a local repair response, topical application of osteoinductive agents, or biomaterials that promote implant fixation.

Material/Methods: The present study evaluated the effect of a single local injection of simvastatin on screw fixation in an ovariectomized rat model of osteoporosis.

Results: Dual-energy X-ray absorptiometry, micro-computed tomography, histology, and biomechanical tests revealed that 5 and 10 mg simvastatin significantly improved bone mineral density by 18.2% and 22.4%, respectively (P<0.05); increased bone volume fraction by 51.0% and 57.9%, trabecular thickness by 16.4% and 18.9%, trabeculae number by 112.0% and 107.1%, and percentage of osseointegration by 115.7% and 126.3%; and decreased trabeculae separation by 34.1% and 36.6%, respectively (all P<0.01). Bone mineral apposition rate was significantly increased (P<0.01). Furthermore, implant fixation was significantly increased (P<0.05), and bone morphogenetic protein 2 (BMP2) expression was markedly increased. Local injection of a single dose of simvastatin also promoted angiogenesis. Vessel number, volume, thickness, surface area, and vascular volume per tissue volume were significantly increased (all P<0.01). Vascular endothelial growth factor (VEGF), VEGF receptor-2, von Willebrand factor, and platelet endothelial cell adhesion molecule-1 expression were enhanced.

Conclusions: A single local injection of simvastatin significantly increased bone formation, promoted osseointegration, and enhanced implant fixation in ovariectomized rats. The underlying mechanism appears to involve enhanced BMP2 expression and angiogenesis in the target bone.

语种英语
WOS记录号WOS:000354694800001
项目编号81171693 ; 81100895 ; NCET-10-0202 ; SS2015AA020304
资助机构National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; National High Technology Research and Development Program of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51838
专题北京大学第三临床医学院_骨科
作者单位1.Beijing Key Lab Spinal Dis, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100871, Peoples R China
3.Peking Univ, Dept Neurol, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Tan, Jie,Yang, Ning,Fu, Xin,et al. Single-Dose Local Simvastatin Injection Improves Implant Fixation via Increased Angiogenesis and Bone Formation in an Ovariectomized Rat Model[J]. MEDICAL SCIENCE MONITOR,2015,21:1428-1439.
APA Tan, Jie.,Yang, Ning.,Fu, Xin.,Cui, Yueyi.,Guo, Qi.,...&Song, Chunli.(2015).Single-Dose Local Simvastatin Injection Improves Implant Fixation via Increased Angiogenesis and Bone Formation in an Ovariectomized Rat Model.MEDICAL SCIENCE MONITOR,21,1428-1439.
MLA Tan, Jie,et al."Single-Dose Local Simvastatin Injection Improves Implant Fixation via Increased Angiogenesis and Bone Formation in an Ovariectomized Rat Model".MEDICAL SCIENCE MONITOR 21(2015):1428-1439.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Tan, Jie]的文章
[Yang, Ning]的文章
[Fu, Xin]的文章
百度学术
百度学术中相似的文章
[Tan, Jie]的文章
[Yang, Ning]的文章
[Fu, Xin]的文章
必应学术
必应学术中相似的文章
[Tan, Jie]的文章
[Yang, Ning]的文章
[Fu, Xin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。