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学科主题: 临床医学
题名:
Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients
作者: Fan Xiao-hong1; Wu Chi-hong1; Wang Li-fen1; Zheng Ying-ying1; Yao Ying2; Lu Hai-ying1; Xu Xiao-yuan1; Wei Lai3
关键词: hepatitis C ; cryoglobulinemia ; virological response
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-11-20
DOI: 10.3760/cma.j.issn.0366-6999.2012.22.019
卷: 125, 期:22, 页:4014-4017
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: MIXED CRYOGLOBULINEMIA ; II CRYOGLOBULINEMIA ; VIRUS-INFECTION ; PLUS RIBAVIRIN ; PREVALENCE ; MANAGEMENT ; VASCULITIS ; THERAPY
英文摘要:

Background Mixed cryoglobulinemia (MC) is one of the most common and severe symptoms in chronic hepatitis C patients. The aim of this study was to investigate whether mixed cryoglobulinemia is a factor associated with sustained virological response in chronic hepatitis C patients treated with combination therapy of pegylated interferon alpha-2a and ribavirin.

Methods This is a single-center study including 57 chronic hepatitis C patients who received combination treatments of pegylated interferon alfa-2a and ribavirin. Serum cryoglobulin was detected by cryoprecipitation prior to treatment. Serum hepatitis C virus (HCV) RNA levels were checked before treatment, during the fourth and 12th week of treatment, and during the 24th week after cessation of treatment. The genotype of HCV was determined at baseline. Logistic regression analysis was used to assess the factors associated with sustained virological response.

Results Twenty-five patients were with MC (43.9%). Twenty-four weeks after cessation of antiviral treatment, sustained virological response achievement in MC+ patients was significantly lower than that in MC- patients (32.0% vs. 75.0%, P=0.001). Univariate Logistic regression analysis and multivariate Logistic regression analysis found that only MC (odds ratio: 6.375; 95% CI: 1.998-20.343, P=0.002) was negatively associated with sustained virological response achievement.

Conclusion MC is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients treated with pegylated interferon alpha-2a and ribavirin. Chin Med J 2012;125(22):4014-4017

语种: 英语
所属项目编号: 2008ZX10002-013 ; 30771906 ; 20090001110081
项目资助者: National Major Project for Infectious Diseases Control ; National Natural Science Foundation of China ; Ph.D. Programs Foundation of Ministry of Education of China
WOS记录号: WOS:000312748100020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51839
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Nephrol, Beijing 100034, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China

Recommended Citation:
Fan Xiao-hong,Wu Chi-hong,Wang Li-fen,et al. Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients[J]. CHINESE MEDICAL JOURNAL,2012,125(22):4014-4017.
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