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学科主题临床医学
Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients
Fan Xiao-hong1; Wu Chi-hong1; Wang Li-fen1; Zheng Ying-ying1; Yao Ying2; Lu Hai-ying1; Xu Xiao-yuan1; Wei Lai3
关键词Hepatitis c Cryoglobulinemia Virological Response
刊名CHINESE MEDICAL JOURNAL
2012-11-20
DOI10.3760/cma.j.issn.0366-6999.2012.22.019
125期:22页:4014-4017
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]MIXED CRYOGLOBULINEMIA ; II CRYOGLOBULINEMIA ; VIRUS-INFECTION ; PLUS RIBAVIRIN ; PREVALENCE ; MANAGEMENT ; VASCULITIS ; THERAPY
英文摘要

Background Mixed cryoglobulinemia (MC) is one of the most common and severe symptoms in chronic hepatitis C patients. The aim of this study was to investigate whether mixed cryoglobulinemia is a factor associated with sustained virological response in chronic hepatitis C patients treated with combination therapy of pegylated interferon alpha-2a and ribavirin.

Methods This is a single-center study including 57 chronic hepatitis C patients who received combination treatments of pegylated interferon alfa-2a and ribavirin. Serum cryoglobulin was detected by cryoprecipitation prior to treatment. Serum hepatitis C virus (HCV) RNA levels were checked before treatment, during the fourth and 12th week of treatment, and during the 24th week after cessation of treatment. The genotype of HCV was determined at baseline. Logistic regression analysis was used to assess the factors associated with sustained virological response.

Results Twenty-five patients were with MC (43.9%). Twenty-four weeks after cessation of antiviral treatment, sustained virological response achievement in MC+ patients was significantly lower than that in MC- patients (32.0% vs. 75.0%, P=0.001). Univariate Logistic regression analysis and multivariate Logistic regression analysis found that only MC (odds ratio: 6.375; 95% CI: 1.998-20.343, P=0.002) was negatively associated with sustained virological response achievement.

Conclusion MC is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients treated with pegylated interferon alpha-2a and ribavirin. Chin Med J 2012;125(22):4014-4017

语种英语
WOS记录号WOS:000312748100020
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51839
专题北京大学第一临床医学院_感染疾病科
北京大学第二临床医学院_北京大学肝病研究所
北京大学第三临床医学院_妇产科
作者单位1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Nephrol, Beijing 100034, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Fan Xiao-hong,Wu Chi-hong,Wang Li-fen,et al. Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients[J]. CHINESE MEDICAL JOURNAL,2012,125(22):4014-4017.
APA Fan Xiao-hong.,Wu Chi-hong.,Wang Li-fen.,Zheng Ying-ying.,Yao Ying.,...&Wei Lai.(2012).Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients.CHINESE MEDICAL JOURNAL,125(22),4014-4017.
MLA Fan Xiao-hong,et al."Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients".CHINESE MEDICAL JOURNAL 125.22(2012):4014-4017.
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