IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China
He, Zhong1; Chen, Rong1; Zhou, Yingfang2; Geng, Li3; Zhang, Zhenyu4; Chen, Shuling2; Yao, Yanjun3; Lu, Junli4; Lin, Shouqing1
关键词Vitex Agnus Castus Premenstrual Syndrome Efficacy And Safety
刊名MATURITAS
2009-05-20
DOI10.1016/j.maturitas.2009.01.006
63期:1页:99-103
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Geriatrics & Gerontology ; Obstetrics & Gynecology
研究领域[WOS]Geriatrics & Gerontology ; Obstetrics & Gynecology
关键词[WOS]DYSPHORIC DISORDER ; TENSION SYNDROME ; CONTROLLED-TRIAL ; EXTRACT ; SYMPTOMS ; PREVALENCE ; MASTALGIA
英文摘要

Objectives: To investigate the efficacy and safety of VAC BNO 1095 extract in Chinese women suffering from moderate to severe premenstrual syndrome (PMS).

Methods: Prospective, double-blind, placebo controlled, parallel-group, multi-center clinical trial design was employed. After screening and preparation phase lasting three cycles, Eligible patients were randomly assigned into treatment or placebo groups and had treatment with VAC extract or placebo for up to three cycles. Efficacy was assessed using the Chinese version PMS-diary (PMSD) and PMTS.

Results: Two hundred and seventeen women were eligible to enter the treatment phase (TP) and were randomly assigned into the treatment group (108) or the placebo group (109), 208 provided the efficacy data (treatment 104, placebo 104), and 202 completed the treatment phase (treatment 101, placebo 101). The mean total PMSD score decreased from 29.23 at baseline (0 cycle) to 6.41 at the termination (3rd cycle) for the treatment group and from 28.14 at baseline (0 cycle) to 12.64 at the termination (3rd cycle) for the placebo group. The total PMSD score of 3rd cycle was significantly lower than the baseline in both groups (p < 0.0001). The difference in the mean scores from the baseline to the 3rd cycle in the treatment group (22.71 +/- 10.33) was significantly lower than the difference in the placebo group (15.50 +/- 12.94, p < 0.0001). Results of PMTS were similar, the total scores for PMTS were significantly lower between the two groups (p < 0.01) and within each group (p < 0.01). The score was decreased from 26.17 +/- 4.79 to 9.92 +/- 9.01 for the treatment group, and from 27.10 +/- 4.76 to 14.59 +/- 10.69 for the placebo group. A placebo effect of 50% was found in the present study. No serious adverse event (SAE) occurred in both groups.

Conclusion: Vitex agnus castus (VAC BNO 1095 corresponding to 40 mg herbal drug) is a safe, well tolerated and effective drug of the treatment for Chinese women with the moderate to severe PMS. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000267462300019
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51842
专题北京大学第一临床医学院
北京大学第一临床医学院_妇产科
北京大学第三临床医学院_妇产科
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Obstet & Gynaecol, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 3, Dept Obstet & Gynaecol, Beijing 100871, Peoples R China
4.Capital Med Univ, Beijing Chaoyang Hosp, Dept Obstet & Gynaecol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
He, Zhong,Chen, Rong,Zhou, Yingfang,et al. Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China[J]. MATURITAS,2009,63(1):99-103.
APA He, Zhong.,Chen, Rong.,Zhou, Yingfang.,Geng, Li.,Zhang, Zhenyu.,...&Lin, Shouqing.(2009).Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China.MATURITAS,63(1),99-103.
MLA He, Zhong,et al."Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China".MATURITAS 63.1(2009):99-103.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[He, Zhong]的文章
[Chen, Rong]的文章
[Zhou, Yingfang]的文章
百度学术
百度学术中相似的文章
[He, Zhong]的文章
[Chen, Rong]的文章
[Zhou, Yingfang]的文章
必应学术
必应学术中相似的文章
[He, Zhong]的文章
[Chen, Rong]的文章
[Zhou, Yingfang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。