北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学深圳医院  > 耳鼻咽喉科  > 期刊论文
学科主题: 临床医学
题名:
Auditory nerve impulses induced by 980 nm laser
作者: Guan, Tian1; Zhu, Kai1,2; Chen, Fei3; He, Yonghong4; Wang, Jian5; Wu, Mocun1,2; Nie, Guohui6
关键词: near-infrared laser ; cochlear implant ; optical stimulation ; optically evoked compound action potentials
刊名: JOURNAL OF BIOMEDICAL OPTICS
发表日期: 2015-08-01
DOI: 10.1117/1.JBO.20.8.088004
卷: 20, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: GUINEA-PIG COCHLEA ; ROUND WINDOW MEMBRANE ; ELECTRICAL-STIMULATION ; NEURAL STIMULATION ; PULSE DURATION ; NEURONS ; GENTAMICIN ; ELECTRODES ; CELLS
英文摘要:

The discovery that a pulsed laser could trigger an auditory neural response inspired ongoing research on cochlear implants activated by optical stimulus rather than by electrical current. However, most studies to date have used visible light (532 nm) or long-wavelength near-infrared (>1840 nm) and involved making a hole in the cochlea. This paper investigates the effect of optical parameters on the optically evoked compound action potentials (oCAPs) from the guinea pig cochlea, using a pulsed semiconductor near-infrared laser (980 nm) without making a hole in the cochlea. Synchronous trigger laser pulses were used to stimulate the cochlea, before and after deafening, upon varying the pulse duration (30-1000 mu s) and an amount of radiant energy (0-53.2 mJ/cm(2)). oCAPs were successfully recorded after deafening. The amplitude of the oCAPs increased as the infrared radiant energy was increased at a fixed 50 mu s pulse duration, and decreased with a longer pulse duration at a fixed 37.1 mJ/cm(2) radiant energy. The latency of the oCAPs shortened with increasing radiant energy at a fixed pulse duration. With a higher stimulation rate, the amplitude of the oCAPs′ amplitude decreased. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.

语种: 英语
所属项目编号: NSFC81401539 ; NSFC31271056
项目资助者: Nature Science Foundation of China
WOS记录号: WOS:000362516700029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51843
Appears in Collections:北京大学深圳医院_耳鼻咽喉科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Tsinghua Univ, Grad Sch Shenzhen, Biomed Engn Res Ctr, Shenzhen 518055, Guangdong, Peoples R China
2.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China
3.South Univ Sci & Technol China, Dept Elect & Elect Engn, Shenzhen 518055, Guangdong, Peoples R China
4.Tsinghua Univ, Grad Sch Shenzhen, Lab Opt Imaging & Sensing, Shenzhen 518055, Guangdong, Peoples R China
5.Shenzhen Inst Informat Technol, Sch Elect & Commun, Shenzhen 518172, Guangdong, Peoples R China
6.Peking Univ, Shenzhen Hosp, Dept Otolaryngol, Shenzhen 518036, Guangdong, Peoples R China

Recommended Citation:
Guan, Tian,Zhu, Kai,Chen, Fei,et al. Auditory nerve impulses induced by 980 nm laser[J]. JOURNAL OF BIOMEDICAL OPTICS,2015,20(8).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Guan, Tian]'s Articles
[Zhu, Kai]'s Articles
[Chen, Fei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Guan, Tian]‘s Articles
[Zhu, Kai]‘s Articles
[Chen, Fei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace