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学科主题临床医学
Auditory nerve impulses induced by 980 nm laser
Guan, Tian1; Zhu, Kai1,2; Chen, Fei3; He, Yonghong4; Wang, Jian5; Wu, Mocun1,2; Nie, Guohui6
关键词Near-infrared Laser Cochlear Implant Optical Stimulation Optically Evoked Compound Action Potentials
刊名JOURNAL OF BIOMEDICAL OPTICS
2015-08-01
DOI10.1117/1.JBO.20.8.088004
20期:8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]GUINEA-PIG COCHLEA ; ROUND WINDOW MEMBRANE ; ELECTRICAL-STIMULATION ; NEURAL STIMULATION ; PULSE DURATION ; NEURONS ; GENTAMICIN ; ELECTRODES ; CELLS
英文摘要

The discovery that a pulsed laser could trigger an auditory neural response inspired ongoing research on cochlear implants activated by optical stimulus rather than by electrical current. However, most studies to date have used visible light (532 nm) or long-wavelength near-infrared (>1840 nm) and involved making a hole in the cochlea. This paper investigates the effect of optical parameters on the optically evoked compound action potentials (oCAPs) from the guinea pig cochlea, using a pulsed semiconductor near-infrared laser (980 nm) without making a hole in the cochlea. Synchronous trigger laser pulses were used to stimulate the cochlea, before and after deafening, upon varying the pulse duration (30-1000 mu s) and an amount of radiant energy (0-53.2 mJ/cm(2)). oCAPs were successfully recorded after deafening. The amplitude of the oCAPs increased as the infrared radiant energy was increased at a fixed 50 mu s pulse duration, and decreased with a longer pulse duration at a fixed 37.1 mJ/cm(2) radiant energy. The latency of the oCAPs shortened with increasing radiant energy at a fixed pulse duration. With a higher stimulation rate, the amplitude of the oCAPs′ amplitude decreased. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.

语种英语
WOS记录号WOS:000362516700029
项目编号NSFC81401539 ; NSFC31271056
资助机构Nature Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51843
专题北京大学深圳医院_耳鼻咽喉科
作者单位1.Tsinghua Univ, Grad Sch Shenzhen, Biomed Engn Res Ctr, Shenzhen 518055, Guangdong, Peoples R China
2.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China
3.South Univ Sci & Technol China, Dept Elect & Elect Engn, Shenzhen 518055, Guangdong, Peoples R China
4.Tsinghua Univ, Grad Sch Shenzhen, Lab Opt Imaging & Sensing, Shenzhen 518055, Guangdong, Peoples R China
5.Shenzhen Inst Informat Technol, Sch Elect & Commun, Shenzhen 518172, Guangdong, Peoples R China
6.Peking Univ, Shenzhen Hosp, Dept Otolaryngol, Shenzhen 518036, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Guan, Tian,Zhu, Kai,Chen, Fei,et al. Auditory nerve impulses induced by 980 nm laser[J]. JOURNAL OF BIOMEDICAL OPTICS,2015,20(8).
APA Guan, Tian.,Zhu, Kai.,Chen, Fei.,He, Yonghong.,Wang, Jian.,...&Nie, Guohui.(2015).Auditory nerve impulses induced by 980 nm laser.JOURNAL OF BIOMEDICAL OPTICS,20(8).
MLA Guan, Tian,et al."Auditory nerve impulses induced by 980 nm laser".JOURNAL OF BIOMEDICAL OPTICS 20.8(2015).
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