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学科主题: 临床医学
题名:
The Clinical Relevance of IL-17-Producing CD4+CD161+Cell and Its Subpopulations in Primary Sjogren′s Syndrome
作者: Li, Linbo; He, Jing; Zhu, Lei; Yang, Yuqin; Jin, Yuebo; Jia, Rulin; Liu, Xu; Liu, Yanying; Sun, Xiaolin; Li, Zhanguo
刊名: JOURNAL OF IMMUNOLOGY RESEARCH
发表日期: 2015
DOI: 10.1155/2015/307453
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: REGULATORY T-CELLS ; PERIPHERAL-BLOOD ; SALIVARY-GLANDS ; TH17 CELLS ; RHEUMATOID-ARTHRITIS ; MOUSE MODEL ; DISEASE ; EXPRESSION ; LYMPHOCYTES ; CD161
英文摘要:

Objective. Th17 cells have been demonstrated to play an important role in the onset and development of primary Sjogren′s syndrome (pSS). In this study, we evaluated the expansion and clinical significance of circulating CD4+CD161+ T cell and its "effector" (CD4+CD25-CD161+ T cell) and "regulatory" (CD4+CD25+CD161+ T cell) subpopulations. Methods. Fifty-eight pSS patients and 16 healthy controls (HCs) were recruited in our study. The cell populations and intracellular IL-17 expression were analyzed by flow cytometry. The disease activity was evaluated by the EULAR-SS Disease Activity Index (ESSDAI). Autoantibodies were measured by ELISA or indirect immunofluorescence assay. Results. The CD161+ T cell fractions showed higher proportions of IL-17-producing cells. The frequencies of the overall CD4+CD161+ T cell population and its effector subset were positively correlated with disease activity parameters and more severe disease manifestations. A significant elevation of the CD4+CD25+CD161+ T cell subpopulation was observed in the peripheral blood of pSS patients compared to HCs and this subset showed decreased regulatory functions compared with the CD4+CD25+CD161- population. Conclusion. Circulating CD4+CD161+ T cell populations associated with pSS disease activity and severity. These cells might be involved in the development of pSS and could be potential therapeutic targets in the treatment of pSS.

语种: 英语
所属项目编号: 2014BAI07B01 ; 2014AA020527 ; 81471601 ; 7152150 ; Z141107002514064 ; RDB2014-03 ; RDB2014-04
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Municipal Science &amp ; Technology Commission ; Research and Development Fund of Peking University People&prime ; s Hospital
WOS记录号: WOS:000361662700001
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51844
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Clin Immunol Ctr, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China

Recommended Citation:
Li, Linbo,He, Jing,Zhu, Lei,et al. The Clinical Relevance of IL-17-Producing CD4+CD161+Cell and Its Subpopulations in Primary Sjogren′s Syndrome[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2015.
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