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学科主题临床医学
The Clinical Relevance of IL-17-Producing CD4+CD161+Cell and Its Subpopulations in Primary Sjogren′s Syndrome
Li, Linbo; He, Jing; Zhu, Lei; Yang, Yuqin; Jin, Yuebo; Jia, Rulin; Liu, Xu; Liu, Yanying; Sun, Xiaolin; Li, Zhanguo
刊名JOURNAL OF IMMUNOLOGY RESEARCH
2015
DOI10.1155/2015/307453
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]REGULATORY T-CELLS ; PERIPHERAL-BLOOD ; SALIVARY-GLANDS ; TH17 CELLS ; RHEUMATOID-ARTHRITIS ; MOUSE MODEL ; DISEASE ; EXPRESSION ; LYMPHOCYTES ; CD161
英文摘要

Objective. Th17 cells have been demonstrated to play an important role in the onset and development of primary Sjogren′s syndrome (pSS). In this study, we evaluated the expansion and clinical significance of circulating CD4+CD161+ T cell and its "effector" (CD4+CD25-CD161+ T cell) and "regulatory" (CD4+CD25+CD161+ T cell) subpopulations. Methods. Fifty-eight pSS patients and 16 healthy controls (HCs) were recruited in our study. The cell populations and intracellular IL-17 expression were analyzed by flow cytometry. The disease activity was evaluated by the EULAR-SS Disease Activity Index (ESSDAI). Autoantibodies were measured by ELISA or indirect immunofluorescence assay. Results. The CD161+ T cell fractions showed higher proportions of IL-17-producing cells. The frequencies of the overall CD4+CD161+ T cell population and its effector subset were positively correlated with disease activity parameters and more severe disease manifestations. A significant elevation of the CD4+CD25+CD161+ T cell subpopulation was observed in the peripheral blood of pSS patients compared to HCs and this subset showed decreased regulatory functions compared with the CD4+CD25+CD161- population. Conclusion. Circulating CD4+CD161+ T cell populations associated with pSS disease activity and severity. These cells might be involved in the development of pSS and could be potential therapeutic targets in the treatment of pSS.

语种英语
WOS记录号WOS:000361662700001
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51844
专题北京大学第二临床医学院
北京大学第二临床医学院_风湿免疫科
作者单位Peking Univ, Peoples Hosp, Clin Immunol Ctr, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
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GB/T 7714
Li, Linbo,He, Jing,Zhu, Lei,et al. The Clinical Relevance of IL-17-Producing CD4+CD161+Cell and Its Subpopulations in Primary Sjogren′s Syndrome[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2015.
APA Li, Linbo.,He, Jing.,Zhu, Lei.,Yang, Yuqin.,Jin, Yuebo.,...&Li, Zhanguo.(2015).The Clinical Relevance of IL-17-Producing CD4+CD161+Cell and Its Subpopulations in Primary Sjogren′s Syndrome.JOURNAL OF IMMUNOLOGY RESEARCH.
MLA Li, Linbo,et al."The Clinical Relevance of IL-17-Producing CD4+CD161+Cell and Its Subpopulations in Primary Sjogren′s Syndrome".JOURNAL OF IMMUNOLOGY RESEARCH (2015).
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