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学科主题: 临床医学
题名:
EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis
作者: Wang, Cheng-Gang1; Ye, Ying-Jiang1; Yuan, Jing2; Liu, Fang-Fang3; Zhang, Hui1; Wang, Shan1
关键词: Colorectal Neoplasms ; Enhancer of zeste homologue 2 ; STAT6 ; Immunohistochemistry
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2010-05-21
DOI: 10.3748/wjg.v16.i19.2421
卷: 16, 期:19, 页:2421-2427
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: REED-STERNBERG CELLS ; SIGNAL TRANSDUCER ; TRANSCRIPTION-6 STAT6 ; PROSTATE-CANCER ; BREAST-CANCER ; ACTIVATOR ; BMI-1 ; PROLIFERATION ; CARCINOMA ; ENHANCER
英文摘要:

AIM: To investigate the role of enhancer of zeste homologue 2 (EZH2) and STAT6 immunohistochemistry in the evaluation of clinical stages and prognosis of colorectal cancer (CRC).

METHODS: The expression patterns were examined by immunohistochemistry in both tumor and adjacent non-neoplastic tissues of 119 CRC patients who underwent operation during the time period from 2002 to 2004.

RESULTS: The positive rates of EZH2 and STAT6 in CRC cases were 69.7% (83 of 119) and 60.5% (72 of 119), respectively, and there was significant difference when compared with tumor adjacent non-neoplastic tissues (P < 0.05). In all CRC cases, patients with EZH2-positive, or STAT6-positive expression had lower survival rates than those with EZH2-negative or STAT6-negative expression (P = 0.002 and P = 0.005, respectively). Co-expression of EZH2 and STAT6 showed significantly higher levels in CRC cases of high clinical TNM stages (P = 0.001), and the expression of STAT6 was also correlated with lymph node metastasis and distant metastasis (P = 0.001 and P = 0.016, respectively). Multivariate analysis revealed that EZH2 expression was an independent prognostic indicator of CRC (P = 0.039).

CONCLUSION: EZH2 and STAT6 expressions have significant values in distinguishing clinical stages of CRC and predicting the prognosis of the patients. (C) 2010 Baishideng. All rights reserved.

语种: 英语
所属项目编号: 2006AA02A402
项目资助者: National High-Tech Research and Development Program of China
WOS记录号: WOS:000277975100015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51845
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Beijing Univ, Dept Surg Gastroenterol, Surg Oncol Lab, Peoples Hosp, Beijing 100044, Peoples R China
2.Chinese Peoples Liberat Army Hosp, Dept Pathol, Beijing 100036, Peoples R China
3.Beijing Univ, Peoples Hosp, Dept Pathol, Beijing 100044, Peoples R China

Recommended Citation:
Wang, Cheng-Gang,Ye, Ying-Jiang,Yuan, Jing,et al. EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2010,16(19):2421-2427.
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