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学科主题临床医学
Salt and fluid intake in the development of hypertension in peritoneal dialysis patients
Chen, Wei1; Cheng, Li-Tao1; Wang, Tao1
关键词Peritoneal Dialysis Hypertension Salt Intake Fluid Status
刊名RENAL FAILURE
2007
DOI10.1080/08860220701260461
29期:4页:427-432
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]LEFT-VENTRICULAR HYPERTROPHY ; RESIDUAL RENAL-FUNCTION ; BLOOD-PRESSURE ; HEMODIALYSIS-PATIENTS ; CAPD PATIENTS ; ULTRAFILTRATION FAILURE ; VOLUME CONTROL ; RISK-FACTORS ; DISEASE ; PATHOPHYSIOLOGY
英文摘要

Background. Although fluid overload contributes to hypertension in CAPD patients, less attention has been paid to the role of excess salt and fluid intake. Therefore, we investigated the role of salt and fluid intake in the development of hypertension in CAPD patients. Methods. A total of 165 stable CAPD patients were included into this study. Based on the blood pressure in three consecutive months, they were divided into three groups: persistent hypertensive (PH; n = 33), intercurrent hypertensive (IH; n = 58) and persistent normotensive (PN; n = 74). The IH group was further divided into two phases: normotensive and hypertensive. Fluid status was evaluated by clinical assessment and bioimpedance analysis (BIA). Results. There were no differences in age, gender, and duration of dialysis among groups. Patients were more fluid overloaded in the PH group. Extracellular water (ECW), total body water (TBW), and normalized extracellular water by height (NECW) were higher in the PH group than the PN group (16.77 +/- 3.62 L vs. 14.61 +/- 2.92 L for ECW, p < 0.01; 32.22 +/- 8.23 L vs. 28.98 +/- 6.00 L for TBW, p < 0.05; and 10.28 +/- 1.86 Urn vs. 9.08 +/- 1.63L/m for NECW, p < 0.01). However, patients in the PH group also had more total fluid removal (TFR) and total sodium removal (TSR) compared with the PN group (1346.82 +/- 431.27 mUd vs. 1139.28 +/- 412.65 mL/d for TFR, p < 0.05; and 141.52 +/- 61.57 mmol/d vs. 102.42 +/- 62.51 mmol/d for TSR, p < 0.01). The same trend was demonstrated when compared values of hypertensive and normotensive phase in IH group; patients had higher ECW, TBW, NECW, TSR, and PNa when they were in hypertensive phase than in the normotensive phase. Conclusions. This study confirmed that fluid overload was closely associated with the development of hypertension in CAPD patients. It also showed that hypertemive patients were in general more fluid overloaded despite a higher fluid and sodium removal as compared with normotensive patients.

语种英语
WOS记录号WOS:000246966300006
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51846
专题北京大学第三临床医学院_肾内科
北京大学公共卫生学院_公共卫生学院
北京大学第一临床医学院_皮肤性病科
作者单位1.Peking Univ, Hosp 3, Div Nephrol, Inst Nephrol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100083, Peoples R China
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GB/T 7714
Chen, Wei,Cheng, Li-Tao,Wang, Tao. Salt and fluid intake in the development of hypertension in peritoneal dialysis patients[J]. RENAL FAILURE,2007,29(4):427-432.
APA Chen, Wei,Cheng, Li-Tao,&Wang, Tao.(2007).Salt and fluid intake in the development of hypertension in peritoneal dialysis patients.RENAL FAILURE,29(4),427-432.
MLA Chen, Wei,et al."Salt and fluid intake in the development of hypertension in peritoneal dialysis patients".RENAL FAILURE 29.4(2007):427-432.
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