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Significance of anti-cell membrane-associated DNA (mDNA) antibodies in systemic lupus erythematosus
Chen, Hai-Ying; Guo, Jia-Long; Li, Zhan-Guo
关键词Cell Membrane-associated Dna Diagnosis Systemic Lupus Erythematosus
刊名CLINICAL RHEUMATOLOGY
2008-02-01
DOI10.1007/s10067-007-0675-1
27期:2页:183-187
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]LYMPHOCYTES ; SERA
英文摘要

The aim of this study was to evaluate the value of anti-cell membrane-associated DNA (mDNA) antibodies in the diagnosis of systemic lupus erythematosus (SLE). Antibodies against mDNA were detected with indirect immunofluorescence assay in 207 SLE, 167 other rheumatic diseases, and 82 healthy controls. Association of clinical features and anti-mDNA antibodies was analyzed. The prevalence of anti-mDNA antibodies was 73.3% in SLE, 8.3% in Sjogren′s syndrome, and 4.8% in rheumatoid arthritis. The incidences of anti-mDNA antibodies in SLE lacking anti deoxyribonucl eoprotein, antihistone antibodies, antinuclesome antibodies, anti-dsDNA, and anti-Sm antibodies were 73.8, 62.7, 65.3, 57.8 and 51.6%, respectively. Skin rash, alopecia, oral ulcer, and joint pain are more common in patients with anti-mDNA antibodies. The anti-mDNA antibody is one of the most valuable markers in SLE. It is also informative in some SLE patients lacking other autoantibodies.

语种英语
WOS记录号WOS:000252928400007
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51849
专题北京大学第二临床医学院
北京大学第二临床医学院_风湿免疫科
作者单位Beijing Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
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Chen, Hai-Ying,Guo, Jia-Long,Li, Zhan-Guo. Significance of anti-cell membrane-associated DNA (mDNA) antibodies in systemic lupus erythematosus[J]. CLINICAL RHEUMATOLOGY,2008,27(2):183-187.
APA Chen, Hai-Ying,Guo, Jia-Long,&Li, Zhan-Guo.(2008).Significance of anti-cell membrane-associated DNA (mDNA) antibodies in systemic lupus erythematosus.CLINICAL RHEUMATOLOGY,27(2),183-187.
MLA Chen, Hai-Ying,et al."Significance of anti-cell membrane-associated DNA (mDNA) antibodies in systemic lupus erythematosus".CLINICAL RHEUMATOLOGY 27.2(2008):183-187.
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