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学科主题: 临床医学
题名:
Significance of anti-cell membrane-associated DNA (mDNA) antibodies in systemic lupus erythematosus
作者: Chen, Hai-Ying; Guo, Jia-Long; Li, Zhan-Guo
关键词: cell membrane-associated DNA ; diagnosis ; systemic lupus erythematosus
刊名: CLINICAL RHEUMATOLOGY
发表日期: 2008-02-01
DOI: 10.1007/s10067-007-0675-1
卷: 27, 期:2, 页:183-187
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: LYMPHOCYTES ; SERA
英文摘要:

The aim of this study was to evaluate the value of anti-cell membrane-associated DNA (mDNA) antibodies in the diagnosis of systemic lupus erythematosus (SLE). Antibodies against mDNA were detected with indirect immunofluorescence assay in 207 SLE, 167 other rheumatic diseases, and 82 healthy controls. Association of clinical features and anti-mDNA antibodies was analyzed. The prevalence of anti-mDNA antibodies was 73.3% in SLE, 8.3% in Sjogren′s syndrome, and 4.8% in rheumatoid arthritis. The incidences of anti-mDNA antibodies in SLE lacking anti deoxyribonucl eoprotein, antihistone antibodies, antinuclesome antibodies, anti-dsDNA, and anti-Sm antibodies were 73.8, 62.7, 65.3, 57.8 and 51.6%, respectively. Skin rash, alopecia, oral ulcer, and joint pain are more common in patients with anti-mDNA antibodies. The anti-mDNA antibody is one of the most valuable markers in SLE. It is also informative in some SLE patients lacking other autoantibodies.

语种: 英语
WOS记录号: WOS:000252928400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51849
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Beijing Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China

Recommended Citation:
Chen, Hai-Ying,Guo, Jia-Long,Li, Zhan-Guo. Significance of anti-cell membrane-associated DNA (mDNA) antibodies in systemic lupus erythematosus[J]. CLINICAL RHEUMATOLOGY,2008,27(2):183-187.
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