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学科主题: 基础医学
题名:
CLIC4, ERp29, and Smac/DIABLO Derived from Metastatic Cancer Stem-like Cells Stratify Prognostic Risks of Colorectal Cancer
作者: Deng, Yong-Jian1,3,5; Tang, Na3,9; Liu, Chao3,6; Zhang, Jiang-Yu3,7; An, Sheng-Li4; Peng, Yin-Li3; Ma, Li-Li3; Li, Guang-Qiu3; Jiang, Qiang3; Hu, Chun-Ting3; Wang, Ya-Nan2; Liang, Yao-Ze2; Bian, Xiu-Wu8; Fang, Wei-Gang10; Ding, Yan-Qing1,3,5
刊名: CLINICAL CANCER RESEARCH
发表日期: 2014-07-15
DOI: 10.1158/1078-0432.CCR-13-1887
卷: 20, 期:14, 页:3809-3817
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: EPITHELIAL-MESENCHYMAL TRANSITION ; BREAST-CANCER ; PANCREATIC-CANCER ; SELF-RENEWAL ; TUMOR-GROWTH ; COLON-CANCER ; LUNG-CANCER ; EXPRESSION ; MARKERS ; PROGRESSION
英文摘要:

Purpose: Cancer stem-like cells have been well accepted to be involved in recurrence and metastasis of cancers, but the prognostic potential of biomarkers integrating with metastasis and cancer stem-like cells for colorectal cancer is unclear.

Experimental Design: We identified three proteins, CLIC4, ERp29, and Smac/DIABLO, from metastatic cancer stem-like cells of colorectal cancer and verified the proteins′ role in metastatic behaviors. The proteins were detected by IHC in colorectal cancer tumors and matched colonic mucosa from patients with colorectal cancer who underwent radical surgery in the training cohort. The associations between proteins expression levels and five-year disease-specific survival (DSS) were evaluated to predict the survival probability in the training cohort of 421 cases and the validation cohort of 228 cases.

Results: A three-protein panel including CLIC4, ERp29, and Smac/DIABLO, which was generated from multivariate analysis by excluding clinicopathologic characteristics from the training cohort, distinguished patients with colorectal cancer into very low-, low-, middle-, and high-risk groups with significant differences in five-year DSS probability (88.6%, 63.3%, 30.4%, 11.4%; P < 0.001). The panel is independent from tumor-node-metastasis staging system and histologic grading to predict prognosis, and also enables classification of validation cohort into four risk stratifications (five-year DSS probability is 98.2%, 80.2%, 25.6%, and 2.7%; P < 0.001).

Conclusions: CLIC4, ERp29, and Smac/DIABLO integrated into a novel panel based on cancer stem-like cells in association with metastasis stratify the prognostic risks of colorectal cancer. Prediction of risks with molecular markers will benefit clinicians to make decisions of individual management with postoperative colorectal cancer patients. (C) 2014 AACR.

语种: 英语
所属项目编号: 2010CB529402 ; 2010CB529403 ; U1201226 ; 81172381 ; 81372584 ; 81090422 ; 81071735 ; 81201970 ; CXZD1016 ; 2010B031500012
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Nature Science Foundation of China ; Science and Technology Innovation Foundation of Guangdong Higher Education ; National Natural Science Foundation of Guangdong Province, China
WOS记录号: WOS:000339611500021
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51851
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Shenzhen Peoples Hosp, Dept Pathol, Shenzhen, Peoples R China
2.Southern Med Univ, Nanfang Hosp, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China
3.Southern Med Univ, Nanfang Hosp, Dept Gen Surg, Guangzhou 510515, Guangdong, Peoples R China
4.Southern Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China
5.Southern Med Univ, Dept Biostat, Guangzhou 510515, Guangdong, Peoples R China
6.Guangdong Prov Key Lab Mol Tumour Pathol, Guangzhou, Guangdong, Peoples R China
7.Guangdong Gen Hosp, Dept Pathol, Guangzhou, Guangdong, Peoples R China
8.Guangdong Women & Children Hosp, Dept Pathol, Guangzhou, Guangdong, Peoples R China
9.Third Mil Med Univ, Southwest Hosp, Dept Pathol, Chongqing, Peoples R China
10.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Deng, Yong-Jian,Tang, Na,Liu, Chao,et al. CLIC4, ERp29, and Smac/DIABLO Derived from Metastatic Cancer Stem-like Cells Stratify Prognostic Risks of Colorectal Cancer[J]. CLINICAL CANCER RESEARCH,2014,20(14):3809-3817.
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