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学科主题基础医学
Correlation of LAPTM4B polymorphisms with gallbladder carcinoma susceptibility in Chinese patients
Yang, Hua1; Zhai, Guojun2; Ji, Xiaoxu3; Xiong, Fuxia4; Su, Jing5; McNutt, Michael A.5
关键词Laptm4b Gene Polymorphism Susceptibility Gallbladder Carcinoma (Gbc)
刊名MEDICAL ONCOLOGY
2012-12-01
DOI10.1007/s12032-012-0173-4
29期:4页:2809-2813
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; OVARIAN-CARCINOMA ; OVEREXPRESSION ; CANCER ; EXPRESSION ; CELLS ; PROGRESSION ; METASTASIS ; PROGNOSIS ; SURVIVAL
英文摘要

Gallbladder carcinoma (GBC) is a malignancy with an extremely poor prognosis. In order to improve the survival rate, identification of new susceptibility risk factors is of importance. Here, we report findings on the novel cancer-related gene lysosomal protein transmembrane 4 beta (LAPTM4B) that has two alleles designated LAPTM4B*1 and LAPTM4B*2. Allele *1 differs from allele *2 in that it contains one copy of a 19-bp sequence, whereas this sequence is duplicated in exon 1 of allele *2. This study aimed to investigate the relationship of LAPTM4B allelic variation and GBC susceptibility. LAPTM4B genotype was analyzed in 155 healthy individuals and 91 GBC patients by PCR, and the genotypic distribution of LAPTM4B was analyzed with the chi-squared test. The frequency of allele *2 was 37.9 and 24.8% in the GBC and the control groups, respectively, representing a significant difference between these two groups (P < 0.001). LAPTM4B allele *2 may be a risk factor associated with genetic susceptibility to GBC.

语种英语
WOS记录号WOS:000309711600073
项目编号31000622 ; 20100001120043
资助机构National Nature Science Fund ; Specialized Research Fund for the Doctoral Program of Higher Education of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51862
专题北京大学基础医学院_细胞生物学系
北京大学基础医学院
作者单位1.Loma Linda Univ, Dept Pharmacol, Loma Linda, CA 92354 USA
2.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Intervent Radiol & Vasc Surg, Beijing 100191, Peoples R China
4.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China
5.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China
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GB/T 7714
Yang, Hua,Zhai, Guojun,Ji, Xiaoxu,et al. Correlation of LAPTM4B polymorphisms with gallbladder carcinoma susceptibility in Chinese patients[J]. MEDICAL ONCOLOGY,2012,29(4):2809-2813.
APA Yang, Hua,Zhai, Guojun,Ji, Xiaoxu,Xiong, Fuxia,Su, Jing,&McNutt, Michael A..(2012).Correlation of LAPTM4B polymorphisms with gallbladder carcinoma susceptibility in Chinese patients.MEDICAL ONCOLOGY,29(4),2809-2813.
MLA Yang, Hua,et al."Correlation of LAPTM4B polymorphisms with gallbladder carcinoma susceptibility in Chinese patients".MEDICAL ONCOLOGY 29.4(2012):2809-2813.
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