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学科主题: 基础医学
题名:
Correlation of LAPTM4B polymorphisms with gallbladder carcinoma susceptibility in Chinese patients
作者: Yang, Hua1; Zhai, Guojun2; Ji, Xiaoxu3; Xiong, Fuxia4; Su, Jing5; McNutt, Michael A.5
关键词: LAPTM4B ; Gene polymorphism ; Susceptibility ; Gallbladder carcinoma (GBC)
刊名: MEDICAL ONCOLOGY
发表日期: 2012-12-01
DOI: 10.1007/s12032-012-0173-4
卷: 29, 期:4, 页:2809-2813
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; OVARIAN-CARCINOMA ; OVEREXPRESSION ; CANCER ; EXPRESSION ; CELLS ; PROGRESSION ; METASTASIS ; PROGNOSIS ; SURVIVAL
英文摘要:

Gallbladder carcinoma (GBC) is a malignancy with an extremely poor prognosis. In order to improve the survival rate, identification of new susceptibility risk factors is of importance. Here, we report findings on the novel cancer-related gene lysosomal protein transmembrane 4 beta (LAPTM4B) that has two alleles designated LAPTM4B*1 and LAPTM4B*2. Allele *1 differs from allele *2 in that it contains one copy of a 19-bp sequence, whereas this sequence is duplicated in exon 1 of allele *2. This study aimed to investigate the relationship of LAPTM4B allelic variation and GBC susceptibility. LAPTM4B genotype was analyzed in 155 healthy individuals and 91 GBC patients by PCR, and the genotypic distribution of LAPTM4B was analyzed with the chi-squared test. The frequency of allele *2 was 37.9 and 24.8% in the GBC and the control groups, respectively, representing a significant difference between these two groups (P < 0.001). LAPTM4B allele *2 may be a risk factor associated with genetic susceptibility to GBC.

语种: 英语
所属项目编号: 31000622 ; 20100001120043
项目资助者: National Nature Science Fund ; Specialized Research Fund for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000309711600073
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51862
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Loma Linda Univ, Dept Pharmacol, Loma Linda, CA 92354 USA
2.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Intervent Radiol & Vasc Surg, Beijing 100191, Peoples R China
4.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China
5.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Hua,Zhai, Guojun,Ji, Xiaoxu,et al. Correlation of LAPTM4B polymorphisms with gallbladder carcinoma susceptibility in Chinese patients[J]. MEDICAL ONCOLOGY,2012,29(4):2809-2813.
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