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学科主题: 临床医学
题名:
In vivo detection of severity of optic nerve crush using manganese-enhanced magnetic resonance imaging in rats
作者: Feng Yun1,2,3; Luo Lisha1,3; Ma Zhizhong1,2,3; Sun Xiaodong4; Hu Yuntao1,2,3
关键词: manganese ; manganese-enhanced ; agnetic resonance imaging ; optic nerve ; retina
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-02-05
DOI: 10.3760/cma.j.issn.0366-6999.20132245
卷: 127, 期:3, 页:522-527
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: AXONAL-TRANSPORT ; MRI ; REGENERATION ; RESOLUTION ; TOXICITY ; CONTRAST ; PATHWAY ; MODEL
英文摘要:

Background Traumatic optic neuropathy (TON) is one of the reasons for permanent vision loss. Currently, the clinical practices may not be sufficient for direct assessments and comprehensively determining the location and extent of the patients with optic nerve injury in traumatic optic neuropathy. Magnetic resonance imaging (MRI) provides a non-invasive option. However, rare reports have found whether the differentdegree of injury of the optic nerve can be detected by manganese-enhanced MRI (MEMRI). This study aimed to explore the efficacy of MEMRI in the visual pathway for different severity of opitic nerve injury in rats.

Methods The different injuries of mild, moderate, and heavy damages were created by modified reverse tweezer and were evaluated by counting retinal ganglion cells (RGCs) and VEP ananlysis. Sprague-Dawley (SD) rats were intravitreally injected with 2 I of 25 mmol/L MnCl2, which has been confirmed as a safe injection concentration. The contrast-to-noise ratio (CNR) of MEMRI for optic nerve enhancement at different injury levels was measured.

Results The location of the significantly decreased signal point on optic nerve (ON) was corresponding to the location we made. However, similar findings are not obvious, or even have not been observed in 28 days in each group and also in 14 days at F100 group, indicating that MEMRI could be directly intuitive positioned in the early stage on the optic nerve injury.

Conclusions The possibility of using MEMRI in optic nerve injury in a safe injection concentration of 25 mmol/L is confirmed. Therefore, it is possible to detect the severity of the optic nerve by MEMRI examination.

语种: 英语
所属项目编号: 2011CB707506 ; YZZ08-9-13 ; 64508-01
项目资助者: National Basic Research Program of China (973 Grant) ; Seed Fund from the Peking University Third Hospital ; Linghu Fund from the Peking University Third Hospital
WOS记录号: WOS:000333498400022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51874
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Ctr Eye, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Ophthalmol, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Vis Loss & Restorat, Beijing 100191, Peoples R China
4.Shanghai Jiao Tong Univ, Peoples Hosp 1, Dept Ophthalmol, Shanghai 200080, Peoples R China

Recommended Citation:
Feng Yun,Luo Lisha,Ma Zhizhong,et al. In vivo detection of severity of optic nerve crush using manganese-enhanced magnetic resonance imaging in rats[J]. CHINESE MEDICAL JOURNAL,2014,127(3):522-527.
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