IR@PKUHSC  > 北京大学第三临床医学院  > 眼科
学科主题临床医学
In vivo detection of severity of optic nerve crush using manganese-enhanced magnetic resonance imaging in rats
Feng Yun1,2,3; Luo Lisha1,3; Ma Zhizhong1,2,3; Sun Xiaodong4; Hu Yuntao1,2,3
关键词Manganese Manganese-enhanced Agnetic Resonance Imaging Optic Nerve Retina
刊名CHINESE MEDICAL JOURNAL
2014-02-05
DOI10.3760/cma.j.issn.0366-6999.20132245
127期:3页:522-527
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Basic Research Program of China (973 Grant) ; Seed Fund from the Peking University Third Hospital ; Linghu Fund from the Peking University Third Hospital ; National Basic Research Program of China (973 Grant) ; Seed Fund from the Peking University Third Hospital ; Linghu Fund from the Peking University Third Hospital
研究领域[WOS]General & Internal Medicine
关键词[WOS]AXONAL-TRANSPORT ; MRI ; REGENERATION ; RESOLUTION ; TOXICITY ; CONTRAST ; PATHWAY ; MODEL
英文摘要

Background Traumatic optic neuropathy (TON) is one of the reasons for permanent vision loss. Currently, the clinical practices may not be sufficient for direct assessments and comprehensively determining the location and extent of the patients with optic nerve injury in traumatic optic neuropathy. Magnetic resonance imaging (MRI) provides a non-invasive option. However, rare reports have found whether the differentdegree of injury of the optic nerve can be detected by manganese-enhanced MRI (MEMRI). This study aimed to explore the efficacy of MEMRI in the visual pathway for different severity of opitic nerve injury in rats.

Methods The different injuries of mild, moderate, and heavy damages were created by modified reverse tweezer and were evaluated by counting retinal ganglion cells (RGCs) and VEP ananlysis. Sprague-Dawley (SD) rats were intravitreally injected with 2 I of 25 mmol/L MnCl2, which has been confirmed as a safe injection concentration. The contrast-to-noise ratio (CNR) of MEMRI for optic nerve enhancement at different injury levels was measured.

Results The location of the significantly decreased signal point on optic nerve (ON) was corresponding to the location we made. However, similar findings are not obvious, or even have not been observed in 28 days in each group and also in 14 days at F100 group, indicating that MEMRI could be directly intuitive positioned in the early stage on the optic nerve injury.

Conclusions The possibility of using MEMRI in optic nerve injury in a safe injection concentration of 25 mmol/L is confirmed. Therefore, it is possible to detect the severity of the optic nerve by MEMRI examination.

语种英语
所属项目编号2011CB707506 ; YZZ08-9-13 ; 64508-01
资助者National Basic Research Program of China (973 Grant) ; Seed Fund from the Peking University Third Hospital ; Linghu Fund from the Peking University Third Hospital ; National Basic Research Program of China (973 Grant) ; Seed Fund from the Peking University Third Hospital ; Linghu Fund from the Peking University Third Hospital
WOS记录号WOS:000333498400022
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51874
Collection北京大学第三临床医学院_眼科
作者单位1.Peking Univ, Ctr Eye, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Ophthalmol, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Vis Loss & Restorat, Beijing 100191, Peoples R China
4.Shanghai Jiao Tong Univ, Peoples Hosp 1, Dept Ophthalmol, Shanghai 200080, Peoples R China
Recommended Citation
GB/T 7714
Feng Yun,Luo Lisha,Ma Zhizhong,et al. In vivo detection of severity of optic nerve crush using manganese-enhanced magnetic resonance imaging in rats[J]. CHINESE MEDICAL JOURNAL,2014,127(3):522-527.
APA Feng Yun,Luo Lisha,Ma Zhizhong,Sun Xiaodong,&Hu Yuntao.(2014).In vivo detection of severity of optic nerve crush using manganese-enhanced magnetic resonance imaging in rats.CHINESE MEDICAL JOURNAL,127(3),522-527.
MLA Feng Yun,et al."In vivo detection of severity of optic nerve crush using manganese-enhanced magnetic resonance imaging in rats".CHINESE MEDICAL JOURNAL 127.3(2014):522-527.
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