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学科主题: 临床医学
题名:
Fabrication of electrospun silica-titania nanofibers with different silica content and evaluation of the morphology and osteoinductive properties
作者: Wang, Xiaokun1; Zhu, Jingxian2; Yin, Ling1; Liu, Shize1; Zhang, Xin2; Ao, Yingfang2; Chen, Haifeng1
关键词: electrospinning ; nanofibers ; osteoinductive ; silica-titania ; MSCs
刊名: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
发表日期: 2012-12-01
DOI: 10.1002/jbm.a.34293
卷: 100A, 期:12, 页:3511-3517
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: OSTEOBLAST-LIKE CELLS ; METHANOL FUEL-CELL ; TIO2 NANOFIBERS ; FIBER MATS ; IN-VITRO ; HYDROXYAPATITE ; COMPOSITE ; CRYSTALLINITY ; NANOPARTICLES ; SCAFFOLDS
英文摘要:

Ceramic-derived materials have shown enhanced osteogenic potential for bone tissue engineering applications. Silica is the major component of bioglass, and titania, the oxide complex of titanium, has been found to enhance osteoblast differentiation. In this study, three groups of solgel-derived silicatitania fibrous meshes with precursor ratios of Ti:Si = 7:3, 1:1, 3:7 were fabricated by electrospinning. The effects of silica content on the crystal phase and morphology of silicatitania hybrid nanofiber meshes were also analyzed by scanning electron microscopy, X-ray diffraction, and laser confocal microscopy. The osteogenic potential of the silicatitania meshes was evaluated by seeding mesenchymal stem cells (MSCs) on each mesh and determining cell number, osteodifferentiation markers, and osteopontin production over time. Our results show that cells proliferated throughout the mesh surfaces with similar morphology in all groups. Decreased cell proliferation was observed with the fiber meshes compared with glass controls, whereas cell differentiation toward osteoblast was enhanced on the mesh groups, especially on the Ti:Si = 7:3 group. These findings suggest that higher fiber diameter, degree of crystallization, and titania content of nanofibers can enhance osteodifferentiation of MSCs. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:35113517, 2012.

语种: 英语
所属项目编号: 2012CB933903 ; 2011AA030102
项目资助者: Ministry of Science and Technology of China ; Wallace H. Coulter Foundation
WOS记录号: WOS:000310392100038
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51875
Appears in Collections:北京大学第三临床医学院_运动医学研究所_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Inst Sports Med, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Xiaokun,Zhu, Jingxian,Yin, Ling,et al. Fabrication of electrospun silica-titania nanofibers with different silica content and evaluation of the morphology and osteoinductive properties[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2012,100A(12):3511-3517.
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