IR@PKUHSC  > 北京大学第三临床医学院  > 运动医学研究所
学科主题临床医学
Fabrication of electrospun silica-titania nanofibers with different silica content and evaluation of the morphology and osteoinductive properties
Wang, Xiaokun1; Zhu, Jingxian2; Yin, Ling1; Liu, Shize1; Zhang, Xin2; Ao, Yingfang2; Chen, Haifeng1
关键词Electrospinning Nanofibers Osteoinductive Silica-titania Mscs
刊名JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
2012-12-01
DOI10.1002/jbm.a.34293
100A期:12页:3511-3517
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
资助者Ministry of Science and Technology of China ; Wallace H. Coulter Foundation ; Ministry of Science and Technology of China ; Wallace H. Coulter Foundation
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]OSTEOBLAST-LIKE CELLS ; METHANOL FUEL-CELL ; TIO2 NANOFIBERS ; FIBER MATS ; IN-VITRO ; HYDROXYAPATITE ; COMPOSITE ; CRYSTALLINITY ; NANOPARTICLES ; SCAFFOLDS
英文摘要

Ceramic-derived materials have shown enhanced osteogenic potential for bone tissue engineering applications. Silica is the major component of bioglass, and titania, the oxide complex of titanium, has been found to enhance osteoblast differentiation. In this study, three groups of solgel-derived silicatitania fibrous meshes with precursor ratios of Ti:Si = 7:3, 1:1, 3:7 were fabricated by electrospinning. The effects of silica content on the crystal phase and morphology of silicatitania hybrid nanofiber meshes were also analyzed by scanning electron microscopy, X-ray diffraction, and laser confocal microscopy. The osteogenic potential of the silicatitania meshes was evaluated by seeding mesenchymal stem cells (MSCs) on each mesh and determining cell number, osteodifferentiation markers, and osteopontin production over time. Our results show that cells proliferated throughout the mesh surfaces with similar morphology in all groups. Decreased cell proliferation was observed with the fiber meshes compared with glass controls, whereas cell differentiation toward osteoblast was enhanced on the mesh groups, especially on the Ti:Si = 7:3 group. These findings suggest that higher fiber diameter, degree of crystallization, and titania content of nanofibers can enhance osteodifferentiation of MSCs. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:35113517, 2012.

语种英语
所属项目编号2012CB933903 ; 2011AA030102
资助者Ministry of Science and Technology of China ; Wallace H. Coulter Foundation ; Ministry of Science and Technology of China ; Wallace H. Coulter Foundation
WOS记录号WOS:000310392100038
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51875
Collection北京大学第三临床医学院_运动医学研究所
作者单位1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Inst Sports Med, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Wang, Xiaokun,Zhu, Jingxian,Yin, Ling,et al. Fabrication of electrospun silica-titania nanofibers with different silica content and evaluation of the morphology and osteoinductive properties[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2012,100A(12):3511-3517.
APA Wang, Xiaokun.,Zhu, Jingxian.,Yin, Ling.,Liu, Shize.,Zhang, Xin.,...&Chen, Haifeng.(2012).Fabrication of electrospun silica-titania nanofibers with different silica content and evaluation of the morphology and osteoinductive properties.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,100A(12),3511-3517.
MLA Wang, Xiaokun,et al."Fabrication of electrospun silica-titania nanofibers with different silica content and evaluation of the morphology and osteoinductive properties".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 100A.12(2012):3511-3517.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Wang, Xiaokun]'s Articles
[Zhu, Jingxian]'s Articles
[Yin, Ling]'s Articles
百度学术
百度学术Similar articles in
[Wang, Xiaokun]'s Articles
[Zhu, Jingxian]'s Articles
[Yin, Ling]'s Articles
必应学术
必应学术Similar articles in
[Wang, Xiaokun]'s Articles
[Zhu, Jingxian]'s Articles
[Yin, Ling]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.