IR@PKUHSC  > 北京大学第三临床医学院  > 运动医学研究所
学科主题临床医学
Fabrication of electrospun silica-titania nanofibers with different silica content and evaluation of the morphology and osteoinductive properties
Wang, Xiaokun1; Zhu, Jingxian2; Yin, Ling1; Liu, Shize1; Zhang, Xin2; Ao, Yingfang2; Chen, Haifeng1
关键词Electrospinning Nanofibers Osteoinductive Silica-titania Mscs
刊名JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
2012-12-01
DOI10.1002/jbm.a.34293
100A期:12页:3511-3517
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]OSTEOBLAST-LIKE CELLS ; METHANOL FUEL-CELL ; TIO2 NANOFIBERS ; FIBER MATS ; IN-VITRO ; HYDROXYAPATITE ; COMPOSITE ; CRYSTALLINITY ; NANOPARTICLES ; SCAFFOLDS
英文摘要

Ceramic-derived materials have shown enhanced osteogenic potential for bone tissue engineering applications. Silica is the major component of bioglass, and titania, the oxide complex of titanium, has been found to enhance osteoblast differentiation. In this study, three groups of solgel-derived silicatitania fibrous meshes with precursor ratios of Ti:Si = 7:3, 1:1, 3:7 were fabricated by electrospinning. The effects of silica content on the crystal phase and morphology of silicatitania hybrid nanofiber meshes were also analyzed by scanning electron microscopy, X-ray diffraction, and laser confocal microscopy. The osteogenic potential of the silicatitania meshes was evaluated by seeding mesenchymal stem cells (MSCs) on each mesh and determining cell number, osteodifferentiation markers, and osteopontin production over time. Our results show that cells proliferated throughout the mesh surfaces with similar morphology in all groups. Decreased cell proliferation was observed with the fiber meshes compared with glass controls, whereas cell differentiation toward osteoblast was enhanced on the mesh groups, especially on the Ti:Si = 7:3 group. These findings suggest that higher fiber diameter, degree of crystallization, and titania content of nanofibers can enhance osteodifferentiation of MSCs. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:35113517, 2012.

语种英语
WOS记录号WOS:000310392100038
项目编号2012CB933903 ; 2011AA030102
资助机构Ministry of Science and Technology of China ; Wallace H. Coulter Foundation
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51875
专题北京大学第三临床医学院_运动医学研究所
北京大学第一临床医学院_妇产科
北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Inst Sports Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xiaokun,Zhu, Jingxian,Yin, Ling,et al. Fabrication of electrospun silica-titania nanofibers with different silica content and evaluation of the morphology and osteoinductive properties[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2012,100A(12):3511-3517.
APA Wang, Xiaokun.,Zhu, Jingxian.,Yin, Ling.,Liu, Shize.,Zhang, Xin.,...&Chen, Haifeng.(2012).Fabrication of electrospun silica-titania nanofibers with different silica content and evaluation of the morphology and osteoinductive properties.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,100A(12),3511-3517.
MLA Wang, Xiaokun,et al."Fabrication of electrospun silica-titania nanofibers with different silica content and evaluation of the morphology and osteoinductive properties".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 100A.12(2012):3511-3517.
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