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学科主题基础医学
Variations of elemental distribution in brain regions of neonatal rats at different iodine intakes
Zhang, F1; Liu, NQ1; Zhao, XQ1; Zuo, AJ1; Yang, L1; Xu, Q1; Wang, XF1; Huang, YY1; He, W1; Chai, ZF1
关键词iodine deficiency trace element SRXRF cerebral cortex hippocampus
刊名BIOLOGICAL TRACE ELEMENT RESEARCH
2002-12-01
90期:1-3页:227-237
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]TRYPTOPHAN-HYDROXYLASE ACTIVITY ; EXPERIMENTAL HYPOTHYROIDISM ; THYROID-DISEASE ; TRACE-ELEMENTS ; T3 RECEPTORS ; ZINC ; METABOLISM ; DEFICIENCY
英文摘要

Iodine deficiency (ID) can result in irreversible damage to the brain during the fetal and neonatal stages. As the active center of many enzymes, trace elements play essential roles in brain function. In this work, the relative contents and distributions of elements (Cl, Br, Fe, Cu, and Zn) in two important brain regions, the cerebral cortex and hippocampus, of the iodine-deficient model rats were determined by the synchrotron radiation X-ray fluorescence (SRXRF) method. Meanwhile, the ID rats were supplemented with adequate and excessive iodine, respectively. The results indicated that the distributions of trace elements could be influenced by the different iodine intakes in the stage of brain development. In contrast to the control group, the contents of Cl, Br, and Zn in two brain regions showed a significant increase in the ID group; however, both Fe and Cu decreased in the cerebral cortex and increased in the hippocmapus in the ID group. In addition, only slight changes of elemental contents in brain were found between the adequate and excessive iodine-supplemented rats.

语种英语
WOS记录号WOS:000180413500018
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51876
专题基础医学院_解剖学与组织胚胎学系
作者单位1.Acad Sinica, Inst High Energy Phys, Lab Nucl Analyt Tech, Beijing 100039, Peoples R China
2.Acad Sinica, Inst High Energy Phys, Sychrotron Rad Lab, Beijing 100039, Peoples R China
3.Tianjin Med Univ, Inst Endocrinol, Tianjin 300070, Peoples R China
4.Beijing Univ, Ctr Hlth Sci, Dept Anat, Beijing 100083, Peoples R China
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Zhang, F,Liu, NQ,Zhao, XQ,et al. Variations of elemental distribution in brain regions of neonatal rats at different iodine intakes[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2002,90(1-3):227-237.
APA Zhang, F.,Liu, NQ.,Zhao, XQ.,Zuo, AJ.,Yang, L.,...&Chai, ZF.(2002).Variations of elemental distribution in brain regions of neonatal rats at different iodine intakes.BIOLOGICAL TRACE ELEMENT RESEARCH,90(1-3),227-237.
MLA Zhang, F,et al."Variations of elemental distribution in brain regions of neonatal rats at different iodine intakes".BIOLOGICAL TRACE ELEMENT RESEARCH 90.1-3(2002):227-237.
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