北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 药剂学系  > 期刊论文
学科主题: 药学
题名:
c Preparation of a novel liver-targeting nanoparticle of norcantharidin derivative and evaluation of its anti-tumour activity
作者: Hu Zhang-Hong1; Liu Yiang1; Zhang Liang1; Zhou Yi1; Wang Qin1; Bei Yong-Yan1; Xu Jing-Yu1; Wang Wen-Juan1; Zhang Xue-Nong1; Zhang Qiang2
关键词: lactosyl-norcantharidin ; nanoparticles ; asialoglycoprotein receptor ; liver-targeting agents
刊名: JOURNAL OF EXPERIMENTAL NANOSCIENCE
发表日期: 2011
DOI: 10.1080/17458080.2010.489580
卷: 6, 期:2, 页:183-199
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: GALACTOSYLATED LIPOSOMES ; ANTICANCER ACTIVITY ; GENE-TRANSFER ; CELLS ; DELIVERY ; ANALOGS ; MICE ; BIODISTRIBUTION ; MICROSPHERES ; DOXORUBICIN
英文摘要:

In our study, a novel hepatocyte-targeting norcantharidin (NCTD) derivative lactosyl-norcantharidin (Lac-NCTD) was synthesised using ethanediamine as a truss arm, and lactosyl-norcantharidin nanoparticles (Lac-NCTD-NPs) were obtained by an ionic cross-linkage process with an entrapment efficiency of (80.29 +/- 0.56)%. The release of Lac-NCTD-NPs invitro was then investigated by means of a dialysis method, and its sustained effect was evident. The invitro anti-tumour activities of Lac-NCTD and Lac-NCTD-NPs were studied by their cytotoxic effects on HepG2, SMMC-7721 and SGC-7901 cells. The results showed that the IC50 values of Lac-NCTD and Lac-NCTD-NPs cytotoxicity against HepG2 and SMMC-7721 cells were lower compared to NCTD, and the anti-tumour effects could be remarkably inhibited by galactosylated fetal bovine serum (Gal-FBS) as a competitor of the asialoglycoprotein receptor. The cytotoxic effects against SGC-7901 cells were relatively high, even higher than NCTD, and Gal-FBS had no influence on them at all. The amount of Lac-NCTD accumulated in SMMC-7721 cells was assayed by high-performance liquid chromatography, which indicated that Lac-NCTD may be able to permeate the cell membrane in its unchanged form. The anti-tumour activities of Lac-NCTD and Lac-NCTD-NPs invivo were evaluated in mice bearing an H22 tumour. The results suggested that tumour growth was effectively inhibited by all treatments, including NCTD, Lac-NCTD and Lac-NCTD-NPs, with Lac-NCTD-NPs being the most effective, followed by Lac-NCTD. As a result, Lac-NCTD-NPs may be regarded as liver-targeting agents, which combine both active and passive targeting.

语种: 英语
所属项目编号: 2006BAI09B00 ; 07C26223201333 ; BS2005022 ; JHB05-46 ; H200630
项目资助者: National Key Technology R&amp ; D Program in the 11th Five year Plan of China ; National Science and Technology Ministry ; Social Development Foundation of Jiangsu Province ; department of Education of Jinagsu Province ; health department of Jinagsu Province
WOS记录号: WOS:000288952100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51878
Appears in Collections:北京大学药学院_药剂学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Soochow Univ, Coll Pharm, Suzhou 215123, Jiang Su Prov, Peoples R China
2.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Hu Zhang-Hong,Liu Yiang,Zhang Liang,et al. c Preparation of a novel liver-targeting nanoparticle of norcantharidin derivative and evaluation of its anti-tumour activity[J]. JOURNAL OF EXPERIMENTAL NANOSCIENCE,2011,6(2):183-199.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Hu Zhang-Hong]'s Articles
[Liu Yiang]'s Articles
[Zhang Liang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Hu Zhang-Hong]‘s Articles
[Liu Yiang]‘s Articles
[Zhang Liang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace