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学科主题: 口腔医学
题名:
Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt
作者: Hu, Kai1,2; Li, Sheng-lin1,2; Gan, Ye-hua1,2; Wang, Cun-yu3; Yu, Guang-yan1,2
关键词: Salivary adenoid cystic carcinoma ; Metastasis ; Epiregulin ; ERK1/2 ; Akt
刊名: ORAL ONCOLOGY
发表日期: 2009-02-01
DOI: 10.1016/j.oraloncology.2008.04.009
卷: 45, 期:2, 页:156-163
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Oncology ; Dentistry, Oral Surgery & Medicine
关键词[WOS]: EPIDERMAL-GROWTH-FACTOR ; FACTOR INHIBITS ANOIKIS ; BREAST-CANCER ; TUMOR PROGRESSION ; GENE-EXPRESSION ; EPITHELIAL-CELLS ; FACTOR FAMILY ; KAPPA-B ; KINASE ; METASTASIS
英文摘要:

Hematogenous metastasis is one of the most important factors determining the outcome of the patients with salivary adenoid cystic carcinoma (SACC). In the present study, we examined expression profile of genes in SACC cell lines to took for molecules responsible for its unique metastatic trait. A transcriptomic microarray analysis between the tower lung-metastatic rate cell line SACC-83 and the higher lung-metastatic rate cell line SACC-LM were performed, and eight genes, showed by microarray to be highly expressed in SACC-LM, were picked for validation by quantitative real-time PCR. Among the genes, the expression of epiregulin, a novel member of epidermal growth factor family, was 350-folds higher in SACC-LM than in SACC-83. Accordingly, we examined the effects of epiregulin on migration and invasion in SACC-83 as well. as its targeted downstream molecules, and found that epiregulin could promote in vitro migration and invasion in SACC-83. Furthermore, epiregulin not only induced activation of both ERK1/2 and Akt, but also expression of COX-2. In addition, all these effects could be partially blocked by U0126, a specific inhibitor of mitogen-activated protein kinase kinase (MEK or MAPKK), or LY294002, a specific inhibitor of phosphatidylinosilol 3-kinase (PI3K). Conclusively, the results suggest that epiregulin may play an important role in lung metastasis of SACC. (C) 2008 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000263696400011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51879
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
3.Univ Calif Los Angeles, Sch Dent, Div Oral Biol & Med, Lab Mol Signaling, Los Angeles, CA 90095 USA

Recommended Citation:
Hu, Kai,Li, Sheng-lin,Gan, Ye-hua,et al. Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt[J]. ORAL ONCOLOGY,2009,45(2):156-163.
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