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Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt
Hu, Kai1,2; Li, Sheng-lin1,2; Gan, Ye-hua1,2; Wang, Cun-yu3; Yu, Guang-yan1,2
关键词Salivary Adenoid Cystic Carcinoma Metastasis Epiregulin Erk1/2 Akt
刊名ORAL ONCOLOGY
2009-02-01
DOI10.1016/j.oraloncology.2008.04.009
45期:2页:156-163
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Dentistry, Oral Surgery & Medicine
研究领域[WOS]Oncology ; Dentistry, Oral Surgery & Medicine
关键词[WOS]EPIDERMAL-GROWTH-FACTOR ; FACTOR INHIBITS ANOIKIS ; BREAST-CANCER ; TUMOR PROGRESSION ; GENE-EXPRESSION ; EPITHELIAL-CELLS ; FACTOR FAMILY ; KAPPA-B ; KINASE ; METASTASIS
英文摘要

Hematogenous metastasis is one of the most important factors determining the outcome of the patients with salivary adenoid cystic carcinoma (SACC). In the present study, we examined expression profile of genes in SACC cell lines to took for molecules responsible for its unique metastatic trait. A transcriptomic microarray analysis between the tower lung-metastatic rate cell line SACC-83 and the higher lung-metastatic rate cell line SACC-LM were performed, and eight genes, showed by microarray to be highly expressed in SACC-LM, were picked for validation by quantitative real-time PCR. Among the genes, the expression of epiregulin, a novel member of epidermal growth factor family, was 350-folds higher in SACC-LM than in SACC-83. Accordingly, we examined the effects of epiregulin on migration and invasion in SACC-83 as well. as its targeted downstream molecules, and found that epiregulin could promote in vitro migration and invasion in SACC-83. Furthermore, epiregulin not only induced activation of both ERK1/2 and Akt, but also expression of COX-2. In addition, all these effects could be partially blocked by U0126, a specific inhibitor of mitogen-activated protein kinase kinase (MEK or MAPKK), or LY294002, a specific inhibitor of phosphatidylinosilol 3-kinase (PI3K). Conclusively, the results suggest that epiregulin may play an important role in lung metastasis of SACC. (C) 2008 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000263696400011
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51879
专题北京大学口腔医学院
北京大学口腔医学院_外科
北京大学口腔医学院_中心实验室
作者单位1.Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
3.Univ Calif Los Angeles, Sch Dent, Div Oral Biol & Med, Lab Mol Signaling, Los Angeles, CA 90095 USA
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GB/T 7714
Hu, Kai,Li, Sheng-lin,Gan, Ye-hua,et al. Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt[J]. ORAL ONCOLOGY,2009,45(2):156-163.
APA Hu, Kai,Li, Sheng-lin,Gan, Ye-hua,Wang, Cun-yu,&Yu, Guang-yan.(2009).Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt.ORAL ONCOLOGY,45(2),156-163.
MLA Hu, Kai,et al."Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt".ORAL ONCOLOGY 45.2(2009):156-163.
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