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学科主题基础医学
Blood-brain barrier dysfunction in mice induced by lipopolysaccharide is attenuated by dapsone
Zhou, Ting1,2,3; Zhao, Lei1,2,3; Zhan, Rui1,2,3; He, Qihua4; Tong, Yawei1,2,3; Tian, Xiaosheng1,2,3; Wang, Hecheng1,2,3; Zhang, Tao1,2,3; Fu, Yaoyun1,2,3; Sun, Yang1,2,3; Xu, Feng5; Guo, Xiangyang6; Fan, Dongsheng6; Han, Hongbin6; Chui, Dehua1,2,3,6
关键词Dapsone Blood-brain barrier integrity Lipopolysaccharide
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2014-10-24
DOI10.1016/j.bbrc.2014.09.093
453期:3页:419-424
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]ENDOTHELIAL-CELLS ; OXIDATIVE STRESS ; NADPH OXIDASE ; MOUSE-BRAIN ; MODEL ; RATS ; 4,4&prime ; -DIAMINODIPHENYLSULFONE ; INTEGRITY ; ISCHEMIA ; PERMEABILITY
英文摘要

Blood-brain barrier (BBB) dysfunction is a key event in the development of many central nervous system (CNS) diseases, such as septic encephalopathy and stroke. 4,4′-Diaminodiphenylsulfone (DDS, Dapsone) has displayed neuroprotective effect, but whether DDS has protective role on BBB integrity is not clear. This study was designed to examine the effect of DDS on lipopolysaccharide (LPS)-induced BBB disruption and oxidative stress in brain vessels. Using in vivo multiphoton imaging, we found that DDS administration significantly restored BBB integrity compromised by LPS. DDS also increased the expression of tight junction proteins occludin, zona occludens-1 (ZO-1) and claudin-5 in brain vessels. Level of reactive oxygen species (ROS) was reduced by DDS treatment, which may due to decreased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and NOX2 expression. Our results showed that LPS-induced BBB dysfunction could be attenuated by DDS, indicated that DDS has a therapeutic potential for treating CNS infection and other BBB related diseases. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000350267500022
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51882
专题北京大学基础医学院_神经生物学系
北京大学医学部管理机构_医学部
北京大学药学院_天然药物学系
北京大学第一临床医学院_手术室
北京大学第二临床医学院_检验科
北京大学第三临床医学院_神经内科
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Dept Neurobiol, Key Lab Neurosci, Minist Educ, Beijing 100191, Peoples R China
4.Peking Univ, Minist Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Peking Univ, Ctr Med & Hlth Anal, Beijing 100191, Peoples R China
6.Peking Univ, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
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GB/T 7714
Zhou, Ting,Zhao, Lei,Zhan, Rui,et al. Blood-brain barrier dysfunction in mice induced by lipopolysaccharide is attenuated by dapsone[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,453(3):419-424.
APA Zhou, Ting.,Zhao, Lei.,Zhan, Rui.,He, Qihua.,Tong, Yawei.,...&Chui, Dehua.(2014).Blood-brain barrier dysfunction in mice induced by lipopolysaccharide is attenuated by dapsone.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,453(3),419-424.
MLA Zhou, Ting,et al."Blood-brain barrier dysfunction in mice induced by lipopolysaccharide is attenuated by dapsone".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 453.3(2014):419-424.
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