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学科主题: 基础医学
题名:
Blood-brain barrier dysfunction in mice induced by lipopolysaccharide is attenuated by dapsone
作者: Zhou, Ting1,2,3; Zhao, Lei1,2,3; Zhan, Rui1,2,3; He, Qihua4; Tong, Yawei1,2,3; Tian, Xiaosheng1,2,3; Wang, Hecheng1,2,3; Zhang, Tao1,2,3; Fu, Yaoyun1,2,3; Sun, Yang1,2,3; Xu, Feng5; Guo, Xiangyang6; Fan, Dongsheng6; Han, Hongbin6; Chui, Dehua1,2,3,6
关键词: Dapsone ; Blood-brain barrier integrity ; Lipopolysaccharide
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2014-10-24
DOI: 10.1016/j.bbrc.2014.09.093
卷: 453, 期:3, 页:419-424
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: ENDOTHELIAL-CELLS ; OXIDATIVE STRESS ; NADPH OXIDASE ; MOUSE-BRAIN ; MODEL ; RATS ; 4,4&prime ; -DIAMINODIPHENYLSULFONE ; INTEGRITY ; ISCHEMIA ; PERMEABILITY
英文摘要:

Blood-brain barrier (BBB) dysfunction is a key event in the development of many central nervous system (CNS) diseases, such as septic encephalopathy and stroke. 4,4′-Diaminodiphenylsulfone (DDS, Dapsone) has displayed neuroprotective effect, but whether DDS has protective role on BBB integrity is not clear. This study was designed to examine the effect of DDS on lipopolysaccharide (LPS)-induced BBB disruption and oxidative stress in brain vessels. Using in vivo multiphoton imaging, we found that DDS administration significantly restored BBB integrity compromised by LPS. DDS also increased the expression of tight junction proteins occludin, zona occludens-1 (ZO-1) and claudin-5 in brain vessels. Level of reactive oxygen species (ROS) was reduced by DDS treatment, which may due to decreased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and NOX2 expression. Our results showed that LPS-induced BBB dysfunction could be attenuated by DDS, indicated that DDS has a therapeutic potential for treating CNS infection and other BBB related diseases. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2012CB911000 ; 2012CB911004 ; 81171015
项目资助者: National High Technology Research and Development Program of China ; National Natural Science Foundation of China (NSFC)
WOS记录号: WOS:000350267500022
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51882
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Dept Neurobiol, Key Lab Neurosci, Minist Educ, Beijing 100191, Peoples R China
4.Peking Univ, Minist Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Peking Univ, Ctr Med & Hlth Anal, Beijing 100191, Peoples R China
6.Peking Univ, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhou, Ting,Zhao, Lei,Zhan, Rui,et al. Blood-brain barrier dysfunction in mice induced by lipopolysaccharide is attenuated by dapsone[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,453(3):419-424.
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