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学科主题: 临床医学
题名:
The anti-angiogenic activity of human endostatin inhibits bladder cancer growth and its mechanism
作者: Du, ZJ; Hou, SK
关键词: matrix metalloproteinases ; apoptosis ; bladder neoplasms ; bladder
刊名: JOURNAL OF UROLOGY
发表日期: 2003-11-01
DOI: 10.1097/01.ju.0000091879.18156.22
卷: 170, 期:5, 页:2000-2003
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: TUMOR-GROWTH ; APOPTOSIS
英文摘要:

Purpose: We investigated whether recombinant human endostatin can inhibit the growth of bladder cancer in an experimental model and its possible mechanism of action.

Materials and Methods: The recombinant human endostatin protein was induced and confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot assays. Its biological activities and the possible mechanisms of action were studied in vitro and in vivo.

Results: Recombinant human endostatin inhibited the proliferation of endothelial cells (ECV304) but not bladder tumor cells (EJ). Endostatin induced the expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in bladder cancer cells. Endostatin slowed the growth of xenograft bladder tumors. Immunohistochemistry revealed that endostatin blocked angiogenesis by decreasing vascular endothelial growth factor expression and inducing apoptosis in bladder cancer cells.

Conclusions: These findings demonstrate that endostatin can inhibit xenograft bladder cancer growth and this effect is likely to be mediated by regulating matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases and vascular endothelial growth factor expression, and by inducing apoptosis.

语种: 英语
WOS记录号: WOS:000185858400094
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51884
Appears in Collections:北京大学第二临床医学院_泌尿外科_期刊论文

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作者单位: Peking Univ, People Hosp, Dept Urol, Beijing, Peoples R China

Recommended Citation:
Du, ZJ,Hou, SK. The anti-angiogenic activity of human endostatin inhibits bladder cancer growth and its mechanism[J]. JOURNAL OF UROLOGY,2003,170(5):2000-2003.
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