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学科主题临床医学
The anti-angiogenic activity of human endostatin inhibits bladder cancer growth and its mechanism
Du, ZJ; Hou, SK
关键词Matrix Metalloproteinases Apoptosis Bladder Neoplasms Bladder
刊名JOURNAL OF UROLOGY
2003-11-01
DOI10.1097/01.ju.0000091879.18156.22
170期:5页:2000-2003
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]TUMOR-GROWTH ; APOPTOSIS
英文摘要

Purpose: We investigated whether recombinant human endostatin can inhibit the growth of bladder cancer in an experimental model and its possible mechanism of action.

Materials and Methods: The recombinant human endostatin protein was induced and confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot assays. Its biological activities and the possible mechanisms of action were studied in vitro and in vivo.

Results: Recombinant human endostatin inhibited the proliferation of endothelial cells (ECV304) but not bladder tumor cells (EJ). Endostatin induced the expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in bladder cancer cells. Endostatin slowed the growth of xenograft bladder tumors. Immunohistochemistry revealed that endostatin blocked angiogenesis by decreasing vascular endothelial growth factor expression and inducing apoptosis in bladder cancer cells.

Conclusions: These findings demonstrate that endostatin can inhibit xenograft bladder cancer growth and this effect is likely to be mediated by regulating matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases and vascular endothelial growth factor expression, and by inducing apoptosis.

语种英语
WOS记录号WOS:000185858400094
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51884
专题北京大学第二临床医学院_泌尿外科
作者单位Peking Univ, People Hosp, Dept Urol, Beijing, Peoples R China
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GB/T 7714
Du, ZJ,Hou, SK. The anti-angiogenic activity of human endostatin inhibits bladder cancer growth and its mechanism[J]. JOURNAL OF UROLOGY,2003,170(5):2000-2003.
APA Du, ZJ,&Hou, SK.(2003).The anti-angiogenic activity of human endostatin inhibits bladder cancer growth and its mechanism.JOURNAL OF UROLOGY,170(5),2000-2003.
MLA Du, ZJ,et al."The anti-angiogenic activity of human endostatin inhibits bladder cancer growth and its mechanism".JOURNAL OF UROLOGY 170.5(2003):2000-2003.
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