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学科主题: 精神卫生
题名:
Regional pattern of increased water diffusivity in hippocampus and corpus callosum in mild cognitive impairment
作者: Wang, Huali1; Su, Min-Ying1
关键词: mild cognitive impairment ; water diffusivity ; apparent diffusion coefficient ; hippocampus ; corpus callosum
刊名: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
发表日期: 2006
DOI: 10.1159/000094934
卷: 22, 期:3, 页:223-229
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Geriatrics & Gerontology ; Clinical Neurology ; Psychiatry
研究领域[WOS]: Geriatrics & Gerontology ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]: ALZHEIMERS-DISEASE ; WHITE-MATTER ; MRI ; DEGENERATION ; PROGRESSION ; INDICATOR ; ATROPHY ; VOLUME
英文摘要:

Background: Corpus callosum atrophy possibly indicates neuronal degeneration in association cortex in Alzheimer′s disease ( AD). Water diffusivity allows detecting physiological changes that probably occur earlier than structural shrinkage in cerebral regions during the development of AD. Objective: To simultaneously investigate the focal volumetric and early structural changes with apparent diffusion coefficient ( ADC) of corpus callosum in mild cognitive impairment (MCI), and to explore the regional pattern of ADC increase in hippocampus and corpus callosum. Methods: Thirteen subjects with MCI and 13 healthy age-matched control subjects were studied. With three-dimensional volumetric spoiled gradient recalled echo MRI images, we measured the volume of hippocampus and corpus callosum. Using MRI-guided diffusion-weighted imaging analysis, we calculated ADCs from hippocampus and corpus callosum. Within the receiver-operation curve (ROC) statistical framework, areas under ROC curves from hippocampal and callosal ADCs were compared in differentiating between MCI and controls. Results: After normalization to intracranial volume, hippocampal, not callosal, volume was significantly reduced in MCI. ADC values were increased in hippocampus and corpus callosum in MCI. The extent of ADC increase was similar between hippocampus and corpus callosum. Conclusion: Alterations in water diffusivity may precede corpus callosum atrophy during the development of MCI. Diffusion changes might occur simultaneously in allocortex and neocortex in MCI. Copyright (C) 2006 S. Karger AG, Basel.

语种: 英语
WOS记录号: WOS:000242167100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51886
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Psychogeriatr Unit, Beijing 100083, Peoples R China
2.Univ Calif Irvine, Tu & Yuen Ctr Funct Oncoimaging, Irvine, CA USA

Recommended Citation:
Wang, Huali,Su, Min-Ying. Regional pattern of increased water diffusivity in hippocampus and corpus callosum in mild cognitive impairment[J]. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,2006,22(3):223-229.
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