IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Regional pattern of increased water diffusivity in hippocampus and corpus callosum in mild cognitive impairment
Wang, Huali1; Su, Min-Ying1
关键词Mild Cognitive Impairment Water Diffusivity Apparent Diffusion Coefficient Hippocampus Corpus Callosum
刊名DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
2006
DOI10.1159/000094934
22期:3页:223-229
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Geriatrics & Gerontology ; Clinical Neurology ; Psychiatry
研究领域[WOS]Geriatrics & Gerontology ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]ALZHEIMERS-DISEASE ; WHITE-MATTER ; MRI ; DEGENERATION ; PROGRESSION ; INDICATOR ; ATROPHY ; VOLUME
英文摘要

Background: Corpus callosum atrophy possibly indicates neuronal degeneration in association cortex in Alzheimer′s disease ( AD). Water diffusivity allows detecting physiological changes that probably occur earlier than structural shrinkage in cerebral regions during the development of AD. Objective: To simultaneously investigate the focal volumetric and early structural changes with apparent diffusion coefficient ( ADC) of corpus callosum in mild cognitive impairment (MCI), and to explore the regional pattern of ADC increase in hippocampus and corpus callosum. Methods: Thirteen subjects with MCI and 13 healthy age-matched control subjects were studied. With three-dimensional volumetric spoiled gradient recalled echo MRI images, we measured the volume of hippocampus and corpus callosum. Using MRI-guided diffusion-weighted imaging analysis, we calculated ADCs from hippocampus and corpus callosum. Within the receiver-operation curve (ROC) statistical framework, areas under ROC curves from hippocampal and callosal ADCs were compared in differentiating between MCI and controls. Results: After normalization to intracranial volume, hippocampal, not callosal, volume was significantly reduced in MCI. ADC values were increased in hippocampus and corpus callosum in MCI. The extent of ADC increase was similar between hippocampus and corpus callosum. Conclusion: Alterations in water diffusivity may precede corpus callosum atrophy during the development of MCI. Diffusion changes might occur simultaneously in allocortex and neocortex in MCI. Copyright (C) 2006 S. Karger AG, Basel.

语种英语
WOS记录号WOS:000242167100006
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51886
Collection北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Psychogeriatr Unit, Beijing 100083, Peoples R China
2.Univ Calif Irvine, Tu & Yuen Ctr Funct Oncoimaging, Irvine, CA USA
Recommended Citation
GB/T 7714
Wang, Huali,Su, Min-Ying. Regional pattern of increased water diffusivity in hippocampus and corpus callosum in mild cognitive impairment[J]. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,2006,22(3):223-229.
APA Wang, Huali,&Su, Min-Ying.(2006).Regional pattern of increased water diffusivity in hippocampus and corpus callosum in mild cognitive impairment.DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,22(3),223-229.
MLA Wang, Huali,et al."Regional pattern of increased water diffusivity in hippocampus and corpus callosum in mild cognitive impairment".DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 22.3(2006):223-229.
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