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学科主题临床医学
HLA Disparity is not crucial for the survival rate and severity of chronic health conditions in adult recipients following family donor hematopoietic stem cell transplantation
Wang, Meng; Dong, Yu-Jun; Qiu, Zhi-Xiang; Wang, Mang-Ju; Liu, Wei; Wang, Li-Hong; Li, Yuan; Sun, Yu-Hua; Xu, Wei-Lin; Ou, Jin-Ping; Wang, Wen-Sheng; Liang, Ze-Yin; Wang, Qian; Cen, Xi-Nan; Ren, Han-Yun
关键词Hematopoietic Stem Cell Transplantation (Hsct) Survival Rate Quality Of Life (Qol) Chronic Health Conditions (Chcs)
刊名INTERNATIONAL JOURNAL OF HEMATOLOGY
2015
DOI10.1007/s12185-014-1691-y
101期:1页:75-82
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]VERSUS-HOST-DISEASE ; QUALITY-OF-LIFE ; BONE-MARROW-TRANSPLANTATION ; LONG-TERM SURVIVORS ; ANTITHYMOCYTE GLOBULIN ; THYMOCYTE GLOBULIN ; RANDOMIZED-TRIAL ; MOUSE MODELS ; IN-VIVO ; OUTCOMES
英文摘要

The shortage of HLA-identical siblings or unrelated donors has restricted the application of hematopoietic stem cell transplantation (HSCT). Few studies have systematically assessed survival and chronic health conditions (CHCs) in the same cohort of patients after HLA-mismatched/haploidentical (mismatched) family donor transplantation. In the present study, we retrospectively analyzed the survival of 127 adult patients receiving either HLA-matched (71 cases) or HLA-mismatched (56 cases) family donor transplantation. Of 127 patients, 81 patients survived at least 2 years after HSCT and were still alive until the present investigation. We evaluated the CHCs in 76 survivors (41 matched and 35 mismatched). CHC-related information was scored according to the Bone Marrow Transplant Survivor Study questionnaire. There was no significant difference in overall survival or disease-free survival between HLA-matched and -mismatched transplant recipients. The CHCs were less severe in HLA-mismatched recipients than in matched cohorts. Multivariate analysis identified that age over 40 years at transplantation and presence of chronic graft-versus-host disease were independent risk factors for CHCs, while anti-thymocyte globulin-containing conditioning regimens might be protective. However, HLA disparity was not crucial for either the survival rate or CHCs. In conclusion, HLA-mismatched family donor transplantation can achieve comparable therapeutic effects to HLA-identical sibling transplantation.

语种英语
WOS记录号WOS:000347703500012
项目编号8107044881370667 ; 201202017
资助机构National Natural Science Foundation of China ; National Public Health Benefit Research Foundation
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51890
专题北京大学第一临床医学院_血液内科
作者单位Peking Univ, Dept Hematol, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Wang, Meng,Dong, Yu-Jun,Qiu, Zhi-Xiang,et al. HLA Disparity is not crucial for the survival rate and severity of chronic health conditions in adult recipients following family donor hematopoietic stem cell transplantation[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY,2015,101(1):75-82.
APA Wang, Meng.,Dong, Yu-Jun.,Qiu, Zhi-Xiang.,Wang, Mang-Ju.,Liu, Wei.,...&Ren, Han-Yun.(2015).HLA Disparity is not crucial for the survival rate and severity of chronic health conditions in adult recipients following family donor hematopoietic stem cell transplantation.INTERNATIONAL JOURNAL OF HEMATOLOGY,101(1),75-82.
MLA Wang, Meng,et al."HLA Disparity is not crucial for the survival rate and severity of chronic health conditions in adult recipients following family donor hematopoietic stem cell transplantation".INTERNATIONAL JOURNAL OF HEMATOLOGY 101.1(2015):75-82.
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