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学科主题: 临床医学
题名:
HLA Disparity is not crucial for the survival rate and severity of chronic health conditions in adult recipients following family donor hematopoietic stem cell transplantation
作者: Wang, Meng; Dong, Yu-Jun; Qiu, Zhi-Xiang; Wang, Mang-Ju; Liu, Wei; Wang, Li-Hong; Li, Yuan; Sun, Yu-Hua; Xu, Wei-Lin; Ou, Jin-Ping; Wang, Wen-Sheng; Liang, Ze-Yin; Wang, Qian; Cen, Xi-Nan; Ren, Han-Yun
关键词: Hematopoietic stem cell transplantation (HSCT) ; Survival rate ; Quality of life (QOL) ; Chronic health conditions (CHCs)
刊名: INTERNATIONAL JOURNAL OF HEMATOLOGY
发表日期: 2015
DOI: 10.1007/s12185-014-1691-y
卷: 101, 期:1, 页:75-82
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: VERSUS-HOST-DISEASE ; QUALITY-OF-LIFE ; BONE-MARROW-TRANSPLANTATION ; LONG-TERM SURVIVORS ; ANTITHYMOCYTE GLOBULIN ; THYMOCYTE GLOBULIN ; RANDOMIZED-TRIAL ; MOUSE MODELS ; IN-VIVO ; OUTCOMES
英文摘要:

The shortage of HLA-identical siblings or unrelated donors has restricted the application of hematopoietic stem cell transplantation (HSCT). Few studies have systematically assessed survival and chronic health conditions (CHCs) in the same cohort of patients after HLA-mismatched/haploidentical (mismatched) family donor transplantation. In the present study, we retrospectively analyzed the survival of 127 adult patients receiving either HLA-matched (71 cases) or HLA-mismatched (56 cases) family donor transplantation. Of 127 patients, 81 patients survived at least 2 years after HSCT and were still alive until the present investigation. We evaluated the CHCs in 76 survivors (41 matched and 35 mismatched). CHC-related information was scored according to the Bone Marrow Transplant Survivor Study questionnaire. There was no significant difference in overall survival or disease-free survival between HLA-matched and -mismatched transplant recipients. The CHCs were less severe in HLA-mismatched recipients than in matched cohorts. Multivariate analysis identified that age over 40 years at transplantation and presence of chronic graft-versus-host disease were independent risk factors for CHCs, while anti-thymocyte globulin-containing conditioning regimens might be protective. However, HLA disparity was not crucial for either the survival rate or CHCs. In conclusion, HLA-mismatched family donor transplantation can achieve comparable therapeutic effects to HLA-identical sibling transplantation.

语种: 英语
所属项目编号: 8107044881370667 ; 201202017
项目资助者: National Natural Science Foundation of China ; National Public Health Benefit Research Foundation
WOS记录号: WOS:000347703500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51890
Appears in Collections:北京大学第一临床医学院_血液内科_期刊论文

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作者单位: Peking Univ, Dept Hematol, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Wang, Meng,Dong, Yu-Jun,Qiu, Zhi-Xiang,et al. HLA Disparity is not crucial for the survival rate and severity of chronic health conditions in adult recipients following family donor hematopoietic stem cell transplantation[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY,2015,101(1):75-82.
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