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Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients
Zhou, X-J; Yu, L.; Zhu, L.; Hou, P.; Lv, J. -C.; Yu, F.; Zhang, H.
关键词Lupus Nephritis Fcgrt Variable Number Of Tandem Repeats
刊名CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
2009-07-01
27期:4页:609-614
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]NEONATAL FC-RECEPTOR ; REVISED CRITERIA ; ERYTHEMATOSUS ; MICE ; CLASSIFICATION ; CELLS ; BETA(2)-MICROGLOBULIN ; DISEASE ; IGG ; GLOMERULONEPHRITIS
英文摘要

Objective

Studies oil mouse models have indicated that the neonatal Fc receptor (FcRn) plays important roles in a variety of autoimmune diseases. A variable number of tandem repeat (VNTR) polymorphisms within the FCGRT gene have been detected, and were found to affect the expression and functioning of FcRn. This study investigated the possible association of FCGRT VNTR polymorphisms with susceptibility and clinical manifestations in patients with lupus nephritis (LN).

Methods

A total of 404 Hall Chinese subjects, comprising 200 patients with LN and 204 geographically-matched healthy controls, participated in the study. The FCGRT VNTR polymorphism was genotyped by DNA amplification using a touchdown polymerase chain reaction followed by polyacrylamide gel electrophoresis.

Results

The distribution of VNTR polymorphisms within the FCGRT gene in Chinese subjects was different to that in Caucasians. Analysis of allele and genotype frequencies revealed no significant difference between LN patients and controls. There was no significant difference in the clinical features or prognosis in LN patients when stratified by VNTR polymorphism.

Conclusion

Our results suggest that VNTR polymorphisms within the FCGRT promoter are not associated with LN in the Chinese population.

语种英语
WOS记录号WOS:000269889600010
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51897
专题北京大学第一临床医学院_肾脏内科
北京大学精神卫生研究所_护理部
作者单位Peking Univ, Hosp 1, Inst Nephrol, Div Renal, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhou, X-J,Yu, L.,Zhu, L.,et al. Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients[J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,2009,27(4):609-614.
APA Zhou, X-J.,Yu, L..,Zhu, L..,Hou, P..,Lv, J. -C..,...&Zhang, H..(2009).Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients.CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,27(4),609-614.
MLA Zhou, X-J,et al."Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients".CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 27.4(2009):609-614.
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