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学科主题: 临床医学
题名:
Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients
作者: Zhou, X-J; Yu, L.; Zhu, L.; Hou, P.; Lv, J. -C.; Yu, F.; Zhang, H.
关键词: Lupus nephritis ; FCGRT ; variable number of tandem repeats
刊名: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
发表日期: 2009-07-01
卷: 27, 期:4, 页:609-614
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: NEONATAL FC-RECEPTOR ; REVISED CRITERIA ; ERYTHEMATOSUS ; MICE ; CLASSIFICATION ; CELLS ; BETA(2)-MICROGLOBULIN ; DISEASE ; IGG ; GLOMERULONEPHRITIS
英文摘要:

Objective

Studies oil mouse models have indicated that the neonatal Fc receptor (FcRn) plays important roles in a variety of autoimmune diseases. A variable number of tandem repeat (VNTR) polymorphisms within the FCGRT gene have been detected, and were found to affect the expression and functioning of FcRn. This study investigated the possible association of FCGRT VNTR polymorphisms with susceptibility and clinical manifestations in patients with lupus nephritis (LN).

Methods

A total of 404 Hall Chinese subjects, comprising 200 patients with LN and 204 geographically-matched healthy controls, participated in the study. The FCGRT VNTR polymorphism was genotyped by DNA amplification using a touchdown polymerase chain reaction followed by polyacrylamide gel electrophoresis.

Results

The distribution of VNTR polymorphisms within the FCGRT gene in Chinese subjects was different to that in Caucasians. Analysis of allele and genotype frequencies revealed no significant difference between LN patients and controls. There was no significant difference in the clinical features or prognosis in LN patients when stratified by VNTR polymorphism.

Conclusion

Our results suggest that VNTR polymorphisms within the FCGRT promoter are not associated with LN in the Chinese population.

语种: 英语
WOS记录号: WOS:000269889600010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51897
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Inst Nephrol, Div Renal, Beijing 100034, Peoples R China

Recommended Citation:
Zhou, X-J,Yu, L.,Zhu, L.,et al. Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients[J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,2009,27(4):609-614.
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