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学科主题: 临床医学
题名:
Expression of 11 HOX genes is deregulated in esophageal squamous cell carcinoma
作者: Chen, KN1; Gu, ZD1; Ke, Y1; Li, AY1; Shi, XT1; Xu, GW1
刊名: CLINICAL CANCER RESEARCH
发表日期: 2005-02-01
卷: 11, 期:3, 页:1044-1049
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HOMEOBOX GENES ; BREAST-CANCER ; ALTERED HOX ; CHINA ; CARCINOGENESIS ; LEUKEMIA ; LINES
英文摘要:

Purpose: HOX genes are vital for all aspects of mammalian growth and differentiation, and recent data have shown that their deregulated expression is related to carcinogenesis. To date, there has been no systemic study on expression of HOX genes in esophageal carcinoma. We investigated the expression pattern of 39 known HOX genes in cancerous and noncancerous tissue from 36 patients with esophageal squamous cell carcinoma to determine whether their expression is altered in esophageal cancer.

Experimental Design: Thirty-six patients with resectable esophageal squamous cell carcinoma (ESCC) were enrolled in this study. Specific primers were designed for each of 39 HOX genes, and reverse transcription-PCR was done in cancerous and noncancerous samples of these 36 patients. Furthermore, the expression of HOXA9 protein was subjected to Western blot analysis in all 36 paired tissue samples.

Results: Eight of 39 HOX genes were expressed in cancerous but not in noncancerous tissue. Five of 39 HOX genes were expressed both in cancerous and noncancerous tissue. Of the latter, expression of HOXA7, HOXA9, and HOXC6 was significantly higher in cancerous tissue (P < 0.05). The remaining 26 HOX genes were not detected in either types of tissue. HOXA9 protein was expressed in both kinds of tissue (cancer tissue versus noncancerous mucosa: 0.34 +/- 0.32 versus 0.24 +/- 0.27, P = 0.121).

Conclusions: This is the first comprehensive survey of 39 HOX gene expression in ESCC and noncancerous mucosa. Five of the 39 HOX genes were expressed in both types of tissue indicating their possible role in maintaining normal structure and function of adult esophageal mucosa. Eleven of the 39 HOX genes were deregulated in cancer tissue. These genes possibly participate in the carcinogenesis of ESCC.

语种: 英语
WOS记录号: WOS:000226740400012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51902
Appears in Collections:北京大学临床肿瘤学院_胸外科_期刊论文

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作者单位: 1.Anyang Tumor Hosp, Dept Thorac Surg, Anyang, Peoples R China
2.Peking Univ, Dept Thorac Surg, Sch Oncol, Beijing Canc Hosp, Beijing 100036, Peoples R China
3.Peking Univ, Dept Genet, Sch Oncol, Beijing Canc Hosp, Beijing 100036, Peoples R China
4.Peking Univ, Dept Pathol, Sch Oncol, Beijing Canc Hosp, Beijing 100036, Peoples R China
5.Peking Univ, Dept Gen Surg, Sch Oncol, Beijing Canc Hosp, Beijing 100036, Peoples R China

Recommended Citation:
Chen, KN,Gu, ZD,Ke, Y,et al. Expression of 11 HOX genes is deregulated in esophageal squamous cell carcinoma[J]. CLINICAL CANCER RESEARCH,2005,11(3):1044-1049.
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