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3-Hydroxy-3-Methylglutaryl Flavonol Glycosides from Oxytropis falcata
Wang, Shan-Shan1,2; Zhang, Xiao-Jing1,2; Que, Sheng3; Tu, Guang-Zhong4; Wan, Dan1,2; Cheng, Wei1,2; Liang, Hong1,2; Ye, Jia1,2; Zhang, Qing-Ying1,2
刊名JOURNAL OF NATURAL PRODUCTS
2012-07-01
DOI10.1021/np300292f
75期:7页:1359-1364
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program" ; National Natural Science Foundation of China ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]ANTHYLLIS-ONOBRYCHIOIDES ; ASTRAGALUS-CAPRINUS ; ACYL GROUP ; CONSTITUENTS ; CHIRALITY ; SAPONINS ; LEAVES ; ROOTS ; ACID
英文摘要

Five new 3-hydroxy-3-methylglutaryl (HMG) flavonol 3-O-glycosides, named oxytroflavosides A-E (1-5), and two new rhamnocitrin 3-O-glycosides, oxytroflavosides F and G (6 and 7) were isolated from the n-BuOH-soluble fraction of an EtOH extract of Oxytropis falcata together with seven known kaempferol glycosides (8-14), of which six were isolated from the genus Oxytropis for the first time. The structures of these compounds were elucidated by spectroscopic techniques and chemical methods. The absolute configuration of HMG in compounds 1-5 was determined to be S through spectroscopic analysis of the mevalonamide obtained by amidation and reduction of the HMG moiety. Compounds 1-10 were evaluated for anti-inflammatory activities using lipopolysaccharide-induced RAW 264.7 cells, but none of them showed inhibitory effects on NO production.

语种英语
所属项目编号200872006 ; 21172008
资助者National Natural Science Foundation of China ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program" ; National Natural Science Foundation of China ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"
WOS记录号WOS:000306783500016
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51905
专题北京大学药学院
作者单位1.Beijing Inst Microchem, Beijing 100091, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
4.Qinghai Teachers Univ, Minor Teachers Coll, Dept Chem, Xining 810008, Peoples R China
推荐引用方式
GB/T 7714
Wang, Shan-Shan,Zhang, Xiao-Jing,Que, Sheng,et al. 3-Hydroxy-3-Methylglutaryl Flavonol Glycosides from Oxytropis falcata[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(7):1359-1364.
APA Wang, Shan-Shan.,Zhang, Xiao-Jing.,Que, Sheng.,Tu, Guang-Zhong.,Wan, Dan.,...&Zhang, Qing-Ying.(2012).3-Hydroxy-3-Methylglutaryl Flavonol Glycosides from Oxytropis falcata.JOURNAL OF NATURAL PRODUCTS,75(7),1359-1364.
MLA Wang, Shan-Shan,et al."3-Hydroxy-3-Methylglutaryl Flavonol Glycosides from Oxytropis falcata".JOURNAL OF NATURAL PRODUCTS 75.7(2012):1359-1364.
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