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Simultaneous determination of 12 major constituents in Forsythia suspensa by high performance liquid chromatography - DAD method
Guo, Hui; Liu, Ai-Hua; Li, Lie; Guo, De-An
关键词Rp-hplc Forsythia Suspensa Determination Quality Control
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2007-02-19
DOI10.1016/j.jpba.2006.09.033
43期:3页:1000-1006
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]PHENOLIC-COMPOUNDS ; LIGNANS ; FRUITS ; INHIBITION ; GLYCOSIDES ; FRUCTUS
英文摘要

A high performance liquid chromatographic method was developed to simultaneously determine the 12 major constituents of Forsythia suspensa, namely R-suspensaside, S-suspensaside, S-suspensaside methyl ether, (+)-pinoresinol-p-D-glucoside, forsythiaside, (+)-epipinoresinol-4′-O-glucoside, suspensaside A, rutim, phillyrin, (+)-pinoresinol, (+)-epipinoresinol and phillygenin. The HPLC assay was performed on a Zorbax XDB C-18 column with gradient elution of methanol and 0.3% aqueous acetic acid within 55 min. The detection wavelength was 280 nm. All the compounds showed good linearity (r(2) > 0.9998). The method was reproducible with intra- and inter-day variation less than 3%. The recovery of the assay was in the range of 91.2-104.9%. The method was successfully applied to the quantification of 12 constituents in 33 F suspensa samples. The results indicated that the developed assay could be considered as a suitable quality control method for F suspensa. (c) 2006 Elsevier B.V. All rights.

语种英语
WOS记录号WOS:000244623000028
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51911
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biominet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Guo, Hui,Liu, Ai-Hua,Li, Lie,et al. Simultaneous determination of 12 major constituents in Forsythia suspensa by high performance liquid chromatography - DAD method[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2007,43(3):1000-1006.
APA Guo, Hui,Liu, Ai-Hua,Li, Lie,&Guo, De-An.(2007).Simultaneous determination of 12 major constituents in Forsythia suspensa by high performance liquid chromatography - DAD method.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,43(3),1000-1006.
MLA Guo, Hui,et al."Simultaneous determination of 12 major constituents in Forsythia suspensa by high performance liquid chromatography - DAD method".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 43.3(2007):1000-1006.
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