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学科主题: 临床医学
题名:
Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas
作者: Tuo, Ming-Hua1; Huang, Yu-Hua2; Ni, Yun-Bi3; Tsang, Julia Y. S.3; Chan, Siu-Ki4; Shao, Mu-Min5; Tse, Gary M.3
关键词: Mammaglobin ; Gross cystic disease fluid protein 15 ; Breast carcinoma
刊名: HUMAN PATHOLOGY
发表日期: 2013-07-01
DOI: 10.1016/j.humpath.2012.10.009
卷: 44, 期:7, 页:1241-1250
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: PROGNOSTIC VALUE ; CANCER ; GCDFP-15 ; TUMORS ; COEXPRESSION ; FEATURES ; SUBTYPE ; MARKER ; GRADE
英文摘要:

Immunohistochemical analysis of gross cystic disease fluid protein-15 (GCDFP-15) and mammaglobin (MGB) is frequently used in routine practice for assessment of metastases or regional recurrences of breast origin. Breast cancer is highly heterogeneous. Expression of these 2 markers in various breast cancer subtypes has not been well studied. In addition, the usefulness of these two markers in combination in detecting breast origin has not been explored. In this study, a large cohort of breast cancers was evaluated for GCDFP-15 and MGB expression, both individually and combined. Their expression was correlated with cancer subtypes, other biomarkers and clinicopathologic parameters. A higher sensitivity for MGB (42.3%) than GCDFP-15 (31.6%) in detecting cancers of breast origin was observed. Combining both increased the sensitivity further, both for primary tumor (53.0%) and for nodal metastases (69.0%). GCDFP-15 was associated significantly with a breast cancer profile of good prognosis tumors, including lower grade (P < .001), pN (P = .029) and Ki-67 (P < .001) as well as negative basal markers expression (P = .043, .009, and .049 for c-Kit, CK5/6 and epidermal growth factor receptor, respectively) and, thus, may not be sensitive for detection of poor prognosis tumors. MGB has the highest expression in HER2-overexpressing cancers (56.6%), and may be a potentially useful marker for this subtype. Nonetheless, both markers showed low expression in the basal like (BLBC) subtype (11.9% and 21.4% for GCDFP-15 and MGB respectively), therefore, the detection of BLBC remains problematic. Negative results need to be interpreted with caution, and correlation with other clinical findings may be required to exclude the possibility of metastatic BLBC. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000321225000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51925
Appears in Collections:北京大学深圳医院_病理科_期刊论文

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作者单位: 1.KwongWah Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Pathol, Shenzhen 518036, Peoples R China
3.Shenzhen Second People Hosp, Dept Pathol, Shenzhen 12051802, Peoples R China
4.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
5.Guangzhou Univ Tradit, Shenzhen Affiliated Hosp, Dept Pathol, Shenzhen 518020, Peoples R China

Recommended Citation:
Tuo, Ming-Hua,Huang, Yu-Hua,Ni, Yun-Bi,et al. Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas[J]. HUMAN PATHOLOGY,2013,44(7):1241-1250.
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