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Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas
Tuo, Ming-Hua1; Huang, Yu-Hua2; Ni, Yun-Bi3; Tsang, Julia Y. S.3; Chan, Siu-Ki4; Shao, Mu-Min5; Tse, Gary M.3
关键词Mammaglobin Gross Cystic Disease Fluid Protein 15 Breast Carcinoma
刊名HUMAN PATHOLOGY
2013-07-01
DOI10.1016/j.humpath.2012.10.009
44期:7页:1241-1250
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]PROGNOSTIC VALUE ; CANCER ; GCDFP-15 ; TUMORS ; COEXPRESSION ; FEATURES ; SUBTYPE ; MARKER ; GRADE
英文摘要

Immunohistochemical analysis of gross cystic disease fluid protein-15 (GCDFP-15) and mammaglobin (MGB) is frequently used in routine practice for assessment of metastases or regional recurrences of breast origin. Breast cancer is highly heterogeneous. Expression of these 2 markers in various breast cancer subtypes has not been well studied. In addition, the usefulness of these two markers in combination in detecting breast origin has not been explored. In this study, a large cohort of breast cancers was evaluated for GCDFP-15 and MGB expression, both individually and combined. Their expression was correlated with cancer subtypes, other biomarkers and clinicopathologic parameters. A higher sensitivity for MGB (42.3%) than GCDFP-15 (31.6%) in detecting cancers of breast origin was observed. Combining both increased the sensitivity further, both for primary tumor (53.0%) and for nodal metastases (69.0%). GCDFP-15 was associated significantly with a breast cancer profile of good prognosis tumors, including lower grade (P < .001), pN (P = .029) and Ki-67 (P < .001) as well as negative basal markers expression (P = .043, .009, and .049 for c-Kit, CK5/6 and epidermal growth factor receptor, respectively) and, thus, may not be sensitive for detection of poor prognosis tumors. MGB has the highest expression in HER2-overexpressing cancers (56.6%), and may be a potentially useful marker for this subtype. Nonetheless, both markers showed low expression in the basal like (BLBC) subtype (11.9% and 21.4% for GCDFP-15 and MGB respectively), therefore, the detection of BLBC remains problematic. Negative results need to be interpreted with caution, and correlation with other clinical findings may be required to exclude the possibility of metastatic BLBC. (C) 2013 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000321225000005
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51925
专题北京大学深圳医院_病理科
作者单位1.KwongWah Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Pathol, Shenzhen 518036, Peoples R China
3.Shenzhen Second People Hosp, Dept Pathol, Shenzhen 12051802, Peoples R China
4.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
5.Guangzhou Univ Tradit, Shenzhen Affiliated Hosp, Dept Pathol, Shenzhen 518020, Peoples R China
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Tuo, Ming-Hua,Huang, Yu-Hua,Ni, Yun-Bi,et al. Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas[J]. HUMAN PATHOLOGY,2013,44(7):1241-1250.
APA Tuo, Ming-Hua.,Huang, Yu-Hua.,Ni, Yun-Bi.,Tsang, Julia Y. S..,Chan, Siu-Ki.,...&Tse, Gary M..(2013).Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas.HUMAN PATHOLOGY,44(7),1241-1250.
MLA Tuo, Ming-Hua,et al."Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas".HUMAN PATHOLOGY 44.7(2013):1241-1250.
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