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学科主题临床医学
Effect of sildenafil on erectile dysfunction and improvement in the quality of sexual life in China: a multi-center study
Tang, Wen-Hao1; Zhuang, Xin-Jie2; Ma, Lu-Lin1; Hong, Kai1; Zhao, Lian-Ming1; Liu, De-Feng2; Mao, Jia-Ming2; Zhang, Hong-Liang1; Jiang, Hui1
关键词Erectile Dysfunction Sildenafil Sexual Quality China
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015
8期:7页:11539-11543
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]5 INHIBITORS ; MEN ; VALIDATION
英文摘要

Background: Erectile dysfunction (ED) is a common medical condition in middle-aged and elderly men; however, large-scale and multi-center epidemiologic studies about the treatment effects on ED in China are lacking. Objective: To elucidate the efficacy and safety of a phosphodiesterase type 5 inhibitor (PDE5-i) in the treatment of men with ED in China. Methods: Patients clinically diagnosed with ED from 53 andrology centers in 15 metropolitan areas in China who were willing to undergo treatment for ED were enrolled in the study. Each participant received 4 weeks of unique PDE5-i treatment, and completed the following forms (International Index of Erectile Function score 5 [IIEF-5], the Erection Hardness Score [EHS], Self-Esteem and Relationship [SEAR], and SF-36 of Health Related Quality of Life). Pre-and post-treatment data were compared using descriptive analysis. Results: A total of 1956 ED patients were included in this study; 1922 patients provided valid questionnaires for analysis. Four weeks of sildenafil treatment was considered effective and safe. Specifically, the IIEF-5 sores (11.30 +/- 3.7 vs. 20.02 +/- 5.1, P < 0.05), EHS levels (99.1% patients increases to level 3 or 4), and the SEAR scores (32.5 vs. 55.1, P < 0.05) were significantly improved compared to baseline. Sildenafil therapy also significantly improved the satisfaction, enjoyment, and frequency of sexual attempts and sexual activity, as well as physical vigor and mental health scores. Conclusion: The present study provides direct evidence regarding the efficacy and safety of sildenafil therapy in a large sample of Chinese men with ED, thus verifying that sildenafil improved the symptoms and quality of sexual life.

语种英语
WOS记录号WOS:000361557500164
项目编号81200466
资助机构National Natural Science Foundation of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51928
专题北京大学第三临床医学院_泌尿外科
作者单位1.Peking Univ, Dept Urol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Obstet & Gynecol, Ctr Reprod Med,Hosp 3, Key Lab Assisted Reprod,Minist Educ,Beijing Key L, Beijing 100191, Peoples R China
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GB/T 7714
Tang, Wen-Hao,Zhuang, Xin-Jie,Ma, Lu-Lin,et al. Effect of sildenafil on erectile dysfunction and improvement in the quality of sexual life in China: a multi-center study[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(7):11539-11543.
APA Tang, Wen-Hao.,Zhuang, Xin-Jie.,Ma, Lu-Lin.,Hong, Kai.,Zhao, Lian-Ming.,...&Jiang, Hui.(2015).Effect of sildenafil on erectile dysfunction and improvement in the quality of sexual life in China: a multi-center study.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,8(7),11539-11543.
MLA Tang, Wen-Hao,et al."Effect of sildenafil on erectile dysfunction and improvement in the quality of sexual life in China: a multi-center study".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8.7(2015):11539-11543.
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