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学科主题: 临床医学
题名:
Effect of sildenafil on erectile dysfunction and improvement in the quality of sexual life in China: a multi-center study
作者: Tang, Wen-Hao1; Zhuang, Xin-Jie2; Ma, Lu-Lin1; Hong, Kai1; Zhao, Lian-Ming1; Liu, De-Feng2; Mao, Jia-Ming2; Zhang, Hong-Liang1; Jiang, Hui1
关键词: Erectile dysfunction ; sildenafil ; sexual quality ; China
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2015
卷: 8, 期:7, 页:11539-11543
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: 5 INHIBITORS ; MEN ; VALIDATION
英文摘要:

Background: Erectile dysfunction (ED) is a common medical condition in middle-aged and elderly men; however, large-scale and multi-center epidemiologic studies about the treatment effects on ED in China are lacking. Objective: To elucidate the efficacy and safety of a phosphodiesterase type 5 inhibitor (PDE5-i) in the treatment of men with ED in China. Methods: Patients clinically diagnosed with ED from 53 andrology centers in 15 metropolitan areas in China who were willing to undergo treatment for ED were enrolled in the study. Each participant received 4 weeks of unique PDE5-i treatment, and completed the following forms (International Index of Erectile Function score 5 [IIEF-5], the Erection Hardness Score [EHS], Self-Esteem and Relationship [SEAR], and SF-36 of Health Related Quality of Life). Pre-and post-treatment data were compared using descriptive analysis. Results: A total of 1956 ED patients were included in this study; 1922 patients provided valid questionnaires for analysis. Four weeks of sildenafil treatment was considered effective and safe. Specifically, the IIEF-5 sores (11.30 +/- 3.7 vs. 20.02 +/- 5.1, P < 0.05), EHS levels (99.1% patients increases to level 3 or 4), and the SEAR scores (32.5 vs. 55.1, P < 0.05) were significantly improved compared to baseline. Sildenafil therapy also significantly improved the satisfaction, enjoyment, and frequency of sexual attempts and sexual activity, as well as physical vigor and mental health scores. Conclusion: The present study provides direct evidence regarding the efficacy and safety of sildenafil therapy in a large sample of Chinese men with ED, thus verifying that sildenafil improved the symptoms and quality of sexual life.

语种: 英语
所属项目编号: 81200466
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000361557500164
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51928
Appears in Collections:北京大学第三临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Dept Urol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Obstet & Gynecol, Ctr Reprod Med,Hosp 3, Key Lab Assisted Reprod,Minist Educ,Beijing Key L, Beijing 100191, Peoples R China

Recommended Citation:
Tang, Wen-Hao,Zhuang, Xin-Jie,Ma, Lu-Lin,et al. Effect of sildenafil on erectile dysfunction and improvement in the quality of sexual life in China: a multi-center study[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(7):11539-11543.
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