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学科主题: 药学
题名:
The development of site-specific drug delivery nanocarriers based on receptor mediation
作者: Wang, Xueqing; Li, Suxin; Shi, Yujie; Chuan, Xingxing; Li, Ji; Zhong, Ting; Zhang, Hua; Dai, Wenbing; He, Bing; Zhang, Qiang
关键词: Site-specific drug delivery ; Nanocarriers ; Receptor mediation ; Non-therapeutic targets ; Therapeutic targets ; Multi-targeting system
刊名: JOURNAL OF CONTROLLED RELEASE
发表日期: 2014-11-10
DOI: 10.1016/j.jconrel.2014.05.028
卷: 193, 页:139-153
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: TARGETED CO-DELIVERY ; STERICALLY STABILIZED LIPOSOMES ; IN-VITRO EVALUATION ; IMPROVED ANTITUMOR EFFICACY ; MODIFIED STEALTH LIPOSOMES ; BLOOD-BRAIN-BARRIER ; CANCER STEM-CELLS ; TUMOR-CELLS ; POLYMERIC MICELLES ; BREAST-CANCER
英文摘要:

Since they were first reported in 1980, site-specific drug delivery nanocarriers have progressed greatly with the development of nanotechnology and biotechnology, especially in the anti-tumor field. Currently, some of the ligand peptides like RGD have become hot targeting molecules with extensive academic studies and some receptor-medicated nanocarriers are now in clinical trials. Homing peptides have been the preferred ligands thus far due to their low molecular weight, low antigenicity, high modification ratios and low interference in vivo. The major benefit of receptor-mediated nanocarriers over passive ones may be their accumulation within tumors for longer period of time due to their binding to and/or their uptake by cancer cells, preventing them from fast redistribution into systemic circulation. The studies on receptor-mediated nanocarriers are very dynamic currently, advancing gradually from these against non-therapeutic targets to these against therapeutic targets. And recently, more studies were focused on these systems against multiple receptors and the combination therapies with receptor-mediated nanocarriers. However, we still face great challenges, especially in the understanding of receptors, the key issue for receptor-mediated delivery. This review presents the past and ongoing studies on various types of drug delivery systems based on receptor mediation, discusses the prospective and challenges, and introduces the possible trend of study in the future. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81130059 ; 81273456
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000344229000014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51932
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Xueqing,Li, Suxin,Shi, Yujie,et al. The development of site-specific drug delivery nanocarriers based on receptor mediation[J]. JOURNAL OF CONTROLLED RELEASE,2014,193:139-153.
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