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The development of site-specific drug delivery nanocarriers based on receptor mediation
Wang, Xueqing; Li, Suxin; Shi, Yujie; Chuan, Xingxing; Li, Ji; Zhong, Ting; Zhang, Hua; Dai, Wenbing; He, Bing; Zhang, Qiang
关键词Site-specific Drug Delivery Nanocarriers Receptor Mediation Non-therapeutic Targets Therapeutic Targets Multi-targeting System
刊名JOURNAL OF CONTROLLED RELEASE
2014-11-10
DOI10.1016/j.jconrel.2014.05.028
193页:139-153
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]TARGETED CO-DELIVERY ; STERICALLY STABILIZED LIPOSOMES ; IN-VITRO EVALUATION ; IMPROVED ANTITUMOR EFFICACY ; MODIFIED STEALTH LIPOSOMES ; BLOOD-BRAIN-BARRIER ; CANCER STEM-CELLS ; TUMOR-CELLS ; POLYMERIC MICELLES ; BREAST-CANCER
英文摘要

Since they were first reported in 1980, site-specific drug delivery nanocarriers have progressed greatly with the development of nanotechnology and biotechnology, especially in the anti-tumor field. Currently, some of the ligand peptides like RGD have become hot targeting molecules with extensive academic studies and some receptor-medicated nanocarriers are now in clinical trials. Homing peptides have been the preferred ligands thus far due to their low molecular weight, low antigenicity, high modification ratios and low interference in vivo. The major benefit of receptor-mediated nanocarriers over passive ones may be their accumulation within tumors for longer period of time due to their binding to and/or their uptake by cancer cells, preventing them from fast redistribution into systemic circulation. The studies on receptor-mediated nanocarriers are very dynamic currently, advancing gradually from these against non-therapeutic targets to these against therapeutic targets. And recently, more studies were focused on these systems against multiple receptors and the combination therapies with receptor-mediated nanocarriers. However, we still face great challenges, especially in the understanding of receptors, the key issue for receptor-mediated delivery. This review presents the past and ongoing studies on various types of drug delivery systems based on receptor mediation, discusses the prospective and challenges, and introduces the possible trend of study in the future. (C) 2014 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000344229000014
项目编号81130059 ; 81273456
资助机构National Natural Science Foundation of China
引用统计
被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51932
专题北京大学药学院
北京大学基础医学院
北京大学药学院_化学生物学系
北京大学药学院_药剂学系
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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GB/T 7714
Wang, Xueqing,Li, Suxin,Shi, Yujie,et al. The development of site-specific drug delivery nanocarriers based on receptor mediation[J]. JOURNAL OF CONTROLLED RELEASE,2014,193:139-153.
APA Wang, Xueqing.,Li, Suxin.,Shi, Yujie.,Chuan, Xingxing.,Li, Ji.,...&Zhang, Qiang.(2014).The development of site-specific drug delivery nanocarriers based on receptor mediation.JOURNAL OF CONTROLLED RELEASE,193,139-153.
MLA Wang, Xueqing,et al."The development of site-specific drug delivery nanocarriers based on receptor mediation".JOURNAL OF CONTROLLED RELEASE 193(2014):139-153.
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